BMJ Open,
Journal Year:
2022,
Volume and Issue:
12(4), P. e057068 - e057068
Published: April 1, 2022
Introduction
Endodontic
microsurgery
is
a
treatment
of
last
resort
for
preserving
natural
teeth.
According
to
radiographic
evaluation,
the
percentage
complete
healing
after
endodontic
only
74.3%.
The
use
regenerative
techniques
in
large
lesions
(>10
mm
diameter)
therefore
recommended.
most
frequently
used
bone
graft
anorganic
bovine
mineral
(ABBM)
but
this
has
an
osteoconductive
effect.
Thus,
when
platelet-rich
fibrin
(PRF),
reservoir
growth
factors,
together
with
ABBM,
it
increases
This
study
devoted
comparing
clinical
outcomes
PRF
with/without
ABBM
as
grafting
biomaterials
cases
lesion
size
provide
some
valuable
reference
data
dentists.
Methods
and
analysis
Sixteen
patients
who
are
need
will
be
recruited.
randomly
assigned
one
two
groups:
experimental
group,
treated
PRF/ABBM
complex
collagen
membrane,
control
membrane.
Clinical
examination
including
percussion,
mobility
testing
presence/absence
sinus
recorded
at
7
days,
3,
6
12
months
microsurgery.
A
Visual
Analogue
Scale
by
evaluate
pain
1,
3
days
Routine
paralleling
radiographs
obtained
before
follow-up
Cone-beam
CT
(CBCT)
scans
12-month
follow-up.
Bone
formation
evaluated
according
CBCT
radiographs.
execute
time
follow-ups
from
1
June
2021
31
December
2024.
Ethics
dissemination
received
approval
Committee
Peking
University
School
Hospital
Stomatology.
results
disseminated
through
scientific
journals.
Trial
registration
number
Research
registered
International
Trials
Registry
Platform
(ICTRP),
ID:
ChiCTR2100046684.
Journal of Periodontology,
Journal Year:
2022,
Volume and Issue:
93(12), P. 1803 - 1826
Published: Oct. 24, 2022
Abstract
Background
A
large
variety
of
biomaterials,
biologics
and
membranes
have
been
utilized
in
the
past
40
years
for
regenerative
treatment
periodontal
infrabony
defects.
Biologic
agents
progressively
gained
popularity
among
clinicians
are
routinely
used
regeneration.
In
alignment
with
goals
American
Academy
Periodontology
(AAP)
Best
Evidence
Consensus
(BEC)
on
use
biologic
mediators
contemporary
clinical
practice,
aim
this
sytematic
review
was
to
evaluate
effect
agents,
specifically
autogenous
blood‐dervied
products
(ABPs),
enamel
matrix
derivative
(EMD)
recombinant
human
platelet‐derived
growth
factor‐BB
(rhPDGF‐BB),
outcomes
Methods
detailed
systematic
search
conducted
identify
eligible
randomized
control
trials
(RCTs)
reporting
therapy
using
frequentist
mixed‐modeling
approach
network
meta‐analysis
(NMA),
characterized
by
assessment
three
individual
components
an
defect
(the
bone
graft
material
[BG],
agent,
application
a
barrier
membrane)
performed
compare
relative
efficacy
different
components,
therapeutic
modalities
Results
total
153
RCTs
were
included,
150
studies
contributing
NMA.
The
quantitative
analysis
showed
that
addition
significantly
improves
radiographic
outcomes,
as
compared
BG
flap
procedures
alone.
Barrier
enhanced
but
did
not
provide
further
benefits
combination
biologics.
type
(autogenous,
allogeneic,
xenogeneic
or
alloplastic)
agent
(EMD,
platelet‐rich
fibrin
[PRF],
plasma
[PRP]
rhPDGF‐BB)
played
significant
role
final
Allogeneic
BGs
exhibited
statistically
superior
gain
than
synthetic
(p
<
0.05
all
comparisons),
while
rhPDGF‐BB
PRF
demonstrated
higher
stability
gingival
margin
0.01)
fill/gain
0.05),
together
greater,
although
significant,
attachment
level
pocket
depth
reduction,
EMD
PRP.
Overall,
largest
size
most
parameters,
including
gain,
less
recession
linear
gain.
Considering
relatively
high
number
presenting
unclear
risk
bias,
strength
recommendation
supporting
PRP
judged
weak,
EMD,
deemed
favor.
Conclusions
Biologics
enhance
therapy.
Combination
therapies
involving
+
membrane
be
monotherapies.
choice
seems
impact
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(17)
Published: Feb. 21, 2024
Abstract
Periodontitis
is
a
dysbiosis‐driven
inflammatory
disease
affecting
the
tooth‐supporting
tissues,
characterized
by
their
progressive
resorption,
which
can
ultimately
lead
to
tooth
loss.
A
step‐wise
therapeutic
approach
employed
for
periodontitis.
After
an
initial
behavioral
and
non‐surgical
phase,
intra‐bony
or
furcation
defects
may
be
amenable
regenerative
procedures.
This
review
discusses
technologies
periodontal
regeneration,
highlighting
current
limitations
future
research
areas.
The
search,
performed
on
MEDLINE
database,
has
identified
available
biomaterials,
including
biologicals
(autologous
platelet
concentrates,
hydrogels),
bone
grafts
(pure
putty),
membranes.
Biologicals
have
been
critically
analyzed
in
terms
of
composition,
mechanism
action,
clinical
applications.
Although
certain
degree
regeneration
predictable
class
II
defects,
complete
defect
closure
hardly
achieved.
Moreover,
treating
III
remains
challenging.
key
properties
required
functional
are
discussed,
none
commercially
biomaterials
possess
all
ideal
characteristics.
Therefore,
needed
promote
advancement
more
effective
targeted
therapies
Lastly,
improving
design
reporting
studies
suggested
strictly
adhering
Consolidated
Standards
Reporting
Trials
(CONSORT)
2010
statement.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: April 16, 2024
Platelet-rich
fibrin,
a
classical
autologous-derived
bioactive
material,
consists
of
fibrin
scaffold
and
its
internal
loading
growth
factors,
platelets,
leukocytes,
with
the
gradual
degradation
slow
release
physiological
doses
factors.
PRF
promotes
vascular
regeneration,
proliferation
migration
osteoblast-related
cells
such
as
mesenchymal
cells,
osteoblasts,
osteoclasts
while
having
certain
immunomodulatory
anti-bacterial
effects.
has
excellent
osteogenic
potential
been
widely
used
in
field
bone
tissue
engineering
dentistry.
However,
there
are
still
some
limitations
PRF,
improvement
biological
properties
is
one
most
important
issues
to
be
solved.
Therefore,
it
often
combined
scaffolds
enhance
mechanical
delay
degradation.
In
this
paper,
we
present
systematic
review
development
platelet-rich
derivatives,
structure
mechanisms,
applications,
optimization
broaden
their
clinical
applications
provide
guidance
for
translation.
Odontology,
Journal Year:
2024,
Volume and Issue:
112(4), P. 1047 - 1068
Published: May 21, 2024
Abstract
One
of
the
most
promising
approaches
to
correct
periodontal
bone
defects
and
achieve
regeneration
is
platelet-rich
fibrin
(PRF).
This
systematic
review
meta-analysis
aimed
evaluate
using
PRF
compared
other
regenerative
treatments.
The
data
search
retrieval
process
followed
PRISMA
guidelines.
An
electronic
MEDLINE,
Cochrane,
PubMed
databases
was
performed,
selecting
exclusively
randomized
clinical
trials
where
following
were
measured:
probing
depth
reduction
(PD),
attachment
level
gain
(CAL),
radiographic
fill
(RBF).
Out
284
selected
articles,
32
chosen
based
on
inclusion
criteria.
use
(PRF)
+
open
flap
debridement
(OFD),
metformin,
plasma
(PRP),
OFD/bone
graft
(BG)
significantly
reduced
PD
improved
CAL
RBF.
However,
combination
BG,
STATINS
CAL.
intervention
combined
with
different
treatments
such
as
OFD,
PRP,
has
a
significant
impact
improving
APL Bioengineering,
Journal Year:
2022,
Volume and Issue:
6(3)
Published: Sept. 1, 2022
Platelet
concentrates
(PCs)
are
easily
obtained
from
autogenous
whole
blood
after
centrifugation
and
have
evolved
through
three
generations
of
development
to
include
platelet-rich
plasma,
fibrin,
concentrated
growth
factor.
Currently,
PCs
widely
used
for
sinus
floor
elevation,
alveolar
ridge
preservation,
periodontal
bone
defects,
guided
regeneration,
treatment
gingival
recession.
More
recently,
been
leveraged
tissue
regeneration
promote
oral
soft
hard
in
implant
dentistry
regenerative
periodontology.
ideal
this
purpose
because
they
a
high
concentration
platelets,
factors,
cytokines.
Platelets
shown
release
extracellular
vesicles
(P-EVs),
which
thought
be
essential
PC-induced
regeneration.
This
study
reviewed
the
clinical
application
P-EVs
surgery
Biomaterials Research,
Journal Year:
2022,
Volume and Issue:
26(1)
Published: Sept. 30, 2022
Destruction
of
alveolar
bone
and
periodontal
ligament
due
to
disease
often
requires
surgical
treatment
reconstruct
the
biological
construction
functions
periodontium.
Despite
significant
advances
in
dental
implants
past
two
decades,
it
remains
a
major
challenge
adapt
grafts
barrier
membrane
surgery
complicated
anatomy
tooth
defect
contours.
Herein,
we
developed
novel
biphasic
hierarchical
architecture
with
modularized
shape
based
on
achieve
ideal
outcomes.
The
integrated
comprising
nonstoichiometric
wollastonite
(nCSi)
scaffolds
gelatin
methacrylate/silanized
hydroxypropyl
methylcellulose
(GelMA/Si-HPMC)
hydrogel
was
fabricated
by
digital
light
processing
(DLP)
photo-crosslinked
injection
technique
respectively.
rheological
parameters,
mechanical
properties
degradation
rates
composite
hydrogels
were
investigated.
L-929
cells
cultured
samples
evaluate
biocompatibility
cell
effect.
Cell
scratch
assay,
alkaline
phosphatase
(ALP)
staining,
alizarin
red
(AR)
staining
used
reveal
migration
osteogenic
ability
mouse
mandible-derived
osteoblasts
(MOBs).
Subsequently,
critical-size
one-wall
model
dogs
prepared
tissue
reconstruction
potential
architecture.
personalized
integrating
tightly
nCSi
exhibited
favorable
viability
vitro,
while
assay
showed
that
osteoblast
drastically
correlated
Si-HPMC
content
hydrogel.
equivalent
has
proven
good
physiochemical
properties,
its
potent
occlusive
effect
vivo;
meanwhile,
architectures
exerted
strong
regeneration
capability
intrabony
models
dogs.
Histological
examination
effective
biomimetic
system;
however,
soft
invasion
observed
control
group.
Our
results
suggested
such
have
excellent
as
next-generation
oral
implants,
this
precisely
tuned
guided
route
offer
an
opportunity
for
improving
damage
reducing
operation
sensitivity.
