International Journal of Dentistry,
Год журнала:
2023,
Номер
2023, С. 1 - 13
Опубликована: Апрель 29, 2023
Purpose.
The
aim
of
this
study
was
to
compare
clinical
periodontal
conditions
in
HIV-positive
people
on
HAART
with
an
HIV-negative
group,
addition
investigating
factors
associated
periodontitis
the
entire
sample.
Methods.
This
a
cross-sectional
study.
Data
were
collected
by
oral
examination
for
diagnosis
periodontitis,
review
medical
records,
and
application
questionnaire
containing
personal
data,
deleterious
habits,
hygiene
habits
other
variables.
results
analyzed
Pearson’s
χ2
test
Student’s
t-test.
A
logistic
regression
model
constructed
multivariate
analysis
defined
as
dependent
variable.
performed
sample
(HIV+
HIV−)
also
group
consisting
only
living
HIV.
Results.
Individuals
older
than
43
years
old
HIV
more
likely
develop
moderate
severe
(47.80
4.84
times,
respectively).
When
analyzing
HIV+,
age
(OR
=
2.795;
CI
1.080−7.233),
use
nonnucleoside
reverse
transcriptase
inhibitors
(NNRTIs)
2.841;
1.135−7.112)
periodontitis.
Conclusion.
It
possible
observe
higher
prevalence
among
individuals
HIV,
showing
association
between
virus,
advanced
age,
or
Endocrine,
Год журнала:
2024,
Номер
85(2), С. 685 - 694
Опубликована: Март 9, 2024
Abstract
Purpose
To
investigate
the
relationship
between
abnormal
glucose
metabolism,
type
2
diabetes
(T2D),
and
periodontal
disease
(PER)
independent
of
Body
Mass
Index
(BMI),
we
employed
a
genome-wide
cross-trait
approach
to
clarify
association.
Methods
Our
study
utilized
most
extensive
association
studies
conducted
for
populations
European
ancestry,
including
PER,
T2D,
fasting
glucose,
insulin,
2-hour
after
an
oral
challenge,
HOMA-β,
HOMA-IR
(unadjusted
or
adjusted
BMI)
HbA1c.
Results
With
this
approach,
were
able
identify
pleiotropic
loci,
establish
expression-trait
associations,
quantify
global
local
genetic
correlations.
There
was
significant
positive
correlation
T2D
(r
g
=
0.261,
p
2.65
×
10
−13
),
HbA1c
0.182,
4.14
−6
)
as
well
BMI
0.158,
2.34
).
A
also
observed
PER
glycemic
traits
T2D.
We
identified
62
loci
that
impact
both
traits,
Nine
pathways
shared
genes
PER.
Genetically
liability
HOMA-βadjBMI
causally
associated
with
risk
Conclusion
research
has
revealed
link
is
influenced
by
biological
pleiotropy.
Notably,
some
these
links
are
not
related
BMI.
highlights
underlying
patients
regardless
their
Abstract
Background
Although
chronic
periodontitis
has
previously
been
reported
to
be
linked
with
Alzheimer's
disease
(AD),
the
pathogenesis
between
two
is
unclear.
The
purpose
of
this
study
analyze
and
screen
relevant
promising
molecular
markers
(AD).
Methods
In
paper,
we
analyzed
three
AD
expression
datasets
extracted
differentially
expressed
genes
(DEGs),
then
intersected
them
obtained
from
text
mining,
finally
integrated
DEGs.
We
followed
that
by
enriching
matching
cell
signal
cascade
through
DAVID
analysis.
Moreover,
MCODE
Cytoscape
software
was
employed
uncover
protein–protein
interaction
(PPI)
network
hub
gene.
Finally,
verified
our
data
using
a
different
independent
cohort.
Results
gene
set
acquired
abstracting
groups,
12
common
were
obtained.
Functional
enrichment
assessment
uncovered
cross-genes,
which
mainly
morphogenesis
involved
in
neuron
differentiation,
leading
edge
membrane,
receptor
ligand
activity.
After
PPI
creation,
ten
retrieved,
consisting
SPP1,
THY1,
CD44,
ITGB1,
HSPB3,
CREB1,
SST,
UCHL1,
CCL5
BMP7.
function
terms
new
dataset
used
verify
previous
dataset,
found
22
GO
one
pathway,
"ECM-receptor
pathways",
overlapping
functional
terms.
Conclusions
establishment
above-mentioned
candidate
key
genes,
as
well
enriched
signaling
cascades,
provides
for
periodontitis-related
AD,
may
help
diagnosis
treatment
patients
future.
PLoS ONE,
Год журнала:
2022,
Номер
17(8), С. e0272148 - e0272148
Опубликована: Авг. 22, 2022
This
study
explores
the
risk
for
cancer
by
level
of
antibodies
to
anaerobe
oral
bacteria
periodontitis
Tannerella
forsythia
(TF),
Porphyromonas
gingivalis
(PG),
and
Treponema
denticola
(TD)
all
three
collectively
termed
red
complex,
facultative
bacterium
Aggregatibacter
actinomycetemcomitans
(AA).
The
prospective
cohort,
Oslo
II-study
from
2000,
second
screening
1972/73,
has
been
followed
17
½
years
with
regard
incidence
mortality.
A
random
sample
697
elderly
men
comprised
cohort.
antibody
results
measured
enzyme
linked
immunosorbent
assay
(ELISA)
were
used
in
Cox
proportional
hazards
analyses,
quartile
on
a
follow-up.
Among
621
participants
no
prior
diagnoses,
221
developed
cancer.
trend
was
inverse,
are
shown
as
1
st
highest
value
4
th
lowest
levels.
regression
analyses
showed
that
TF
inversely
predicts
bladder
(n
=
22)
Hazard
Ratio
(HR)
1.71
(95%
CI:
1.12,
2.61).
TD
colon
26)
HR
1.52
1.06,
2.19)
1.60
1.05,
2.43).
Antibodies
two
bacteria,
,
an
inverse
relationship
specific
cancers:
cancer,
Lowered
immunological
response
infection,
periodontitis,
is
be
factor
terms
aetiology.
International Journal of Dentistry,
Год журнала:
2023,
Номер
2023, С. 1 - 13
Опубликована: Апрель 29, 2023
Purpose.
The
aim
of
this
study
was
to
compare
clinical
periodontal
conditions
in
HIV-positive
people
on
HAART
with
an
HIV-negative
group,
addition
investigating
factors
associated
periodontitis
the
entire
sample.
Methods.
This
a
cross-sectional
study.
Data
were
collected
by
oral
examination
for
diagnosis
periodontitis,
review
medical
records,
and
application
questionnaire
containing
personal
data,
deleterious
habits,
hygiene
habits
other
variables.
results
analyzed
Pearson’s
χ2
test
Student’s
t-test.
A
logistic
regression
model
constructed
multivariate
analysis
defined
as
dependent
variable.
performed
sample
(HIV+
HIV−)
also
group
consisting
only
living
HIV.
Results.
Individuals
older
than
43
years
old
HIV
more
likely
develop
moderate
severe
(47.80
4.84
times,
respectively).
When
analyzing
HIV+,
age
(OR
=
2.795;
CI
1.080−7.233),
use
nonnucleoside
reverse
transcriptase
inhibitors
(NNRTIs)
2.841;
1.135−7.112)
periodontitis.
Conclusion.
It
possible
observe
higher
prevalence
among
individuals
HIV,
showing
association
between
virus,
advanced
age,
or
