Polypharmacy and Health-Related Quality of Life/Psychological Distress Among Patients With Chronic Disease

Preventing Chronic Disease, Год журнала: 2022, Номер 19

Опубликована: Авг. 15, 2022

To date, no study has investigated the impact of polypharmacy (use ≥5 medications concurrently) on health-related quality life (HRQOL) and psychological distress in a combined sample chronic disease patients with multimorbidity, using diverse HRQOL measures. This aimed to explore association between HRQOL/psychological by data from cross-sectional Flanders (Belgium).We analyzed survey 544 chronically ill recruited June 2019 through 2021. was measured EuroQol-5 Dimension-5 Level questionnaire (EQ-5D-5L) 12-Item Short Form Health Survey (SF-12); Hospital Anxiety Depression Scale (HADS). Multiple linear regression models were built assess distress.Overall, compared without polypharmacy, reported worse EQ-5D-5L index values, EuroQol visual analogue scale (EQ-VAS) scores, SF-12 physical component scores (PCS), mental (MCS), HADS anxiety depression subscales. In final model adjusting for age, sex, educational attainment, remained significantly associated lower terms (β = -0.12; P .008), EQ-VAS -0.11; .01), PCS -0.15; .002) but not (HADS) MCS.This found that negatively domain HRQOL, domain, among diseases. These results may be especially important given their greater risk polypharmacy.

Язык: Английский

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Polypharmacy Prevalence Among Older Adults Based on the Survey of Health, Ageing and Retirement in Europe: An Update

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(4), С. 1330 - 1330

Опубликована: Фев. 17, 2025

Polypharmacy, a common condition among the older population, is associated with adverse outcomes, including higher mortality, falls and hospitalization rates, drug reactions, drug-drug interactions, medication nonadherence, consequently increased healthcare costs. Background/Objectives: This study aims to explore prevalence of polypharmacy its factors adults across 27 European countries Israel. Methods: In this cross-sectional analysis, we used data from participants aged 65 years or Wave 9 Survey Health, Aging, Retirement in Europe (SHARE) database. The variables studied were classified into following categories: sociodemographic, behavioral factors, physical functioning, health, mental living conditions. Results: Our results showed an overall 36.2%, ranging 25.0 51.8%. Slovenia, Greece, Switzerland lowest prevalence, whereas Portugal, Israel, Poland where was highest. Polypharmacy shown be all categories. Conclusions: highly prevalent population. Identification polypharmacy, such as those identified study, important identify monitor groups, which are most vulnerable polypharmacy. Interventions designed reduce should consider these associations.

Язык: Английский

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Association Between Polypharmacy, Anxiety, and Depression Among Chinese Older Adults: Evidence from the Chinese Longitudinal Healthy Longevity Survey

Clinical Interventions in Aging, Год журнала: 2022, Номер Volume 17, С. 235 - 244

Опубликована: Март 1, 2022

To investigate the association between polypharmacy, anxiety, and depression among Chinese older adults.The data used in this study were from Longitudinal Healthy Longevity Survey (CLHLS), 2018 wave. Polypharmacy status was measured by accumulation of self-reported medications. Anxiety assessed Generalized Disorder (GAD-7) scale Center for Epidemiologic Studies Depression Scale (CES-D-10), respectively. Logistic regression models performed.A total 2484 adults (female: 1321, 53.2%) aged 60 to 117 years old included analysis. Regression analysis showed that polypharmacy associated with after controlling covariates. No observed anxiety.There a suggestive link adults. Having might be an indicator possible population, but comprehensive assessment is necessary.

Язык: Английский

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Factors associated with anxiety and depression among patients with chronic obstructive pulmonary disease

Expert Review of Respiratory Medicine, Год журнала: 2024, Номер 18(1-2), С. 59 - 65

Опубликована: Фев. 1, 2024

Objectives This study investigated factors associated with anxiety and depression in COPD outpatients.

Язык: Английский

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Association between physical multimorbidity and common mental health disorders in rural and urban Malawian settings: Preliminary findings from Healthy Lives Malawi long-term conditions survey

PLOS Global Public Health, Год журнала: 2024, Номер 4(4), С. e0002955 - e0002955

Опубликована: Апрель 4, 2024

In low-income Africa, the epidemiology of physical multimorbidity and associated mental health conditions is not well described. We investigated burden, disease combinations, relationship between common disorders in rural urban Malawi using early data from 9,849 adults recruited to an on-going large cross-sectional study on long-term conditions, initiated 2021. Multimorbidity was defined as having two or more measured (diabetes, hypertension) self-reported hypertension, disability, chronic pain, HIV, asthma, stroke, heart disease, epilepsy) conditions. Depression anxiety symptoms were 9-item Patient Health Questionnaire (PHQ-9) 7-item General Anxiety Disorder scale (GAD-7) by total score (range 0–27 0–21, respectively). determined age-standardized prevalence condition combinations. Additionally, we used multiple linear regression models examine association depression symptom scores. Of participants, 81% dwelling, 56% female, median age 30 years (Inter Quartile Range 21–43). The 14.1% (95% CI, 12.5–15.8%) 12.2% 11.6–12.9%), respectively. with disability co-occurred most frequently (18%), those three pain combination (23%). Compared without one ( B -Coefficient ) 0.79; 95% C1 0.63–0.94%), two- 1.36; CI 1.14–1.58%), three- more- 2.23; 1.86–2.59%) increasing score, p -trend <0.001. A comparable ‘dose-response’ observed While direction associations cannot be these data, our findings highlight burden need integrate service delivery Malawi.

Язык: Английский

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Unpacking excessive polypharmacy patterns among individuals living with chronic pain in Quebec: a longitudinal study

Frontiers in Pain Research, Год журнала: 2025, Номер 6

Опубликована: Фев. 21, 2025

Excessive polypharmacy, which can be defined as the concurrent use of ≥10 medications, is prevalent among individuals with chronic pain. However, it remains unclear how may vary between or over time. This study aimed to describe and identify factors associated trajectories excessive polypharmacy. A retrospective longitudinal was conducted using TorSaDE Cohort, links Canadian Community Health Surveys (2007-2016) Quebec health administrative databases. Among 9,156 adults living pain covered by public prescribed drug insurance, presence polypharmacy (yes/no) assessed monthly for one-year post-survey completion (12 time points). Group-based trajectory modelling applied groups similar patterns (trajectories). Multivariable multinomial regression used membership. Four were obtained: (1) "No polypharmacy" (74.8%); (2) "Sometimes in (8.6%); (3) "Often (6.1%); 4) "Always (10.5%). Factors "always membership were: being older, born Canada, having a lower income, higher comorbidity index score, more severe intensity, daily activities prevented pain, reporting arthritis back poorer perceived general health, family physician. Using opioids benzodiazepines, alcohol consumption, doing less physical activity, number prescribers visits physician also predicted always identifies distinct emphasizing key sociodemographic clinical need tailored interventions effective medication management.

Язык: Английский

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The Mediating Role of Emotional Self-Efficacy in the Relationship Between the Number of Medications and Psychological Distress Among Older Adults with Chronic Illness

Journal of Community Health Nursing, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Март 17, 2025

The present study aimed to examine the associations between number of medications, emotional self-efficacy, and psychological distress in older adults with chronic illness. A cross-sectional was conducted a convenience sample 191 Anhui, China. Those participants completed structured questionnaire that included sociodemographic data, status. Pearson correlation analysis used variables. bootstrap method employed analyze mediating role self-efficacy. results showed 10.5% 14.1% might be experiencing symptoms anxiety depression, respectively. Correlation revealed self-efficacy negatively correlated depression. partially mediated relationship medications accounting for 51.9% total effect. Additionally, anxiety, 50.8% However, suppressor effect established polypharmacy-related distress. findings suggested play an important Chinese

Язык: Английский

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One-Year Changes in Depressive Symptoms and Cognitive Function Among Brazilian Older Adults Attending Primary Care

Healthcare, Год журнала: 2025, Номер 13(7), С. 807 - 807

Опубликована: Апрель 3, 2025

Background: Aging is a global phenomenon closely associated with changes in cognitive function and mental health. These conditions substantially burden public health systems adversely affect the quality of life older adults. This study aimed to examine depressive symptoms over 12-month follow-up period cohort Brazilian adults attending primary care. Methods: observational longitudinal included randomized sample individuals aged ≥60 years residing São Paulo, Brazil, registered at Primary Healthcare Unit (PHU). Data collection involved administering sociodemographic questionnaire along two validated instruments: Geriatric Depression Scale-15 (GDS-15) Mini-Mental State Examination (MMSE). Linear regression models were used for analyses. Results: A total 368 included, 63% being men mean age 74.65 years. After one year, showed notable increase, GDS-15 score rising from 5.97 7.48 (Cohen-d = 0.542). Likewise, there was decrease MMSE ranging 19.11 18.88 0.216). Adjusted analyses revealed that baseline (B 0.696; p 0.048; R2 0.19) 0.444; < 0.001; 0.26) predictive their respective deteriorations period. Conclusions: Depressive decline place significant on aging societies. findings underscore importance continuous monitoring early intervention strategies mitigate impact enhance

Язык: Английский

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Optimizing elderly care: A data-driven AI model for predicting polypharmacy risk in the elderly using SHARE data

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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Development and Validation of Polypharmacy-Related Psychological Distress Scale (PPDS): A Preliminary Study

Behavioral Sciences, Год журнала: 2025, Номер 15(5), С. 707 - 707

Опубликована: Май 21, 2025

Polypharmacy is an increasing concern in healthcare due to its potential cause adverse drug reactions and medication non-adherence. The evidence has identified a connection between psychological distress polypharmacy, yet there lack of validated instruments measure this specific type distress. This study aims develop validate the Polypharmacy-related Psychological Distress Scale. followed rigorous scale development procedure, encompassing item creation, development, evaluation. A multi-method design incorporated literature review, Delphi method with eight experts, cross-sectional survey 97 participants. comprehensive range psychometric tests, including content validity, face concurrent internal consistency, construct were utilized assess goodness instrument—the finalized comprised four items. Content validity results deemed satisfactory based on CVI for (I-CVI) (S-CVI). Face was established through incorporation participant feedback. significant correlation found Patient Health Questionnaire-4 Scale, coefficient 0.444 (p < 0.001). demonstrated acceptable reliability, Cronbach’s alpha 0.790 McDonald’s omega 0.937. confirmatory factor analysis revealed unidimensional structure. To summarize, Scale showed reliability preliminary study. It holds promise use by professionals target population, pending further validation.

Язык: Английский

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