Gut microbiota in Alzheimer’s disease: Understanding molecular pathways and potential therapeutic perspectives

Ageing Research Reviews, Год журнала: 2025, Номер 104, С. 102659 - 102659

Опубликована: Янв. 10, 2025

Язык: Английский

---

Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut−brain axis

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117277 - 117277

Опубликована: Авг. 9, 2024

Язык: Английский

---

Underlying Mechanisms behind the Brain–Gut–Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3694 - 3694

Опубликована: Март 26, 2024

Metabolic-associated fatty liver disease (MAFLD) includes several metabolic dysfunctions caused by dysregulation in the brain–gut–liver axis and, consequently, increases cardiovascular risks and dysfunction. In MAFLD, type 2 diabetes mellitus, obesity, syndrome are frequently present; these conditions related to lipogenesis systemic inflammation. This study aimed review connection between MAFLD. The inflammatory process, cellular alterations hepatocytes stellate cells, hypercaloric diet, sedentarism aggravate prognosis of patients with Thus, understand modulation physiopathology it is necessary include organokines involved this process (adipokines, myokines, osteokines, hepatokines) their clinical relevance project future perspectives condition bring light new possibilities therapeutic approaches. Adipokines responsible for activation distinct signaling different tissues, such as insulin pro-inflammatory cytokines, which important balancing substances avoid MAFLD its progression. Myokines improve quantity quality adipose contributing avoiding development Finally, hepatokines decisive improving or not progression through regulation anti-inflammatory organokines.

Язык: Английский

---

Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июнь 10, 2024

Glioblastoma (GBM) is a highly malignant, invasive, and poorly prognosed brain tumor. Unfortunately, active comprehensive treatment does not significantly prolong patient survival. With the deepening of research, it has been found that gut microbiota plays certain role in GBM, can directly or indirectly affect efficacy immune checkpoint inhibitors (ICIs) various ways. (1) The metabolites produced by host’s homeostasis, these function distribution cells, promote inhibit inflammatory responses, phenotype, angiogenesis, response, cell infiltration GBM thereby affecting effectiveness ICIs. (2) Some members may reverse T inhibition, increase anti-tumor activity, ultimately improve ICIs targeting specific immunosuppressive cytokines. (3) participate metabolic process drugs, which degrade, transform, produce metabolites, effective concentration bioavailability drugs. Optimizing structure help (4) also regulate status through axis communication, progression therapeutic response to (5) Given importance for ICI therapy, researchers have begun exploring use fecal transplantation (FMT) transplant healthy optimized patients, order their enhance therapy. Preliminary studies suggest FMT therapy some patients. In summary, crucial regulating with deeper understanding relationship between tumor immunity, expected develop more precise personalized strategies prognosis.

Язык: Английский

---

Impact of Probiotic Supplementation and High-Intensity Interval Training on Primary Dysmenorrhea: A Double-Blind, Randomized Controlled Trial Investigating Inflammation and Hormonal Modulation

Nutrients, Год журнала: 2025, Номер 17(4), С. 622 - 622

Опубликована: Фев. 9, 2025

Background: Dysmenorrhea, categorized as primary (PD) or secondary (SD), significantly affects females during their reproductive years, impairing quality of life, performance, and social relationships. Alongside medical treatment, exercise probiotics are complementary measures for managing PD promoting health. This study examined the impact probiotic supplementation high-intensity interval training (HIIT) on severity, physiological modulation, physical fitness. Methods: Participants, recruited according to dysmenorrhea criteria, were divided into non-PD (control) groups, with group further classified (Dysmen), (DysmenPro), (DysmenEx), both (DysmenExPro). Interventions included 10 weeks HIIT probiotics. Pre- post-intervention assessments questionnaires premenstrual menstrual symptoms, fitness evaluations, blood sample analyses biochemical, hormonal, prostaglandin levels. Results: reduced distress, pain likely due hormone (estradiol, prolactin, progesterone, cortisol) modulation decreased inflammation (high-sensitivity C-reactive protein, PGE2, PGF2α). Cardiovascular endurance explosive strength showed improvement through (HIIT), whereas had no significant effect these aspects While distress they notable pain, inflammation, Dysmenorrhea-related discomforts correlated hormones. Conclusions: The intervention strategy involving may be utilized an alternative treatment alleviate symptoms. Furthermore, this could also incorporated educational health plans promote women's potentially prevent gynecological disorders in adolescent population.

Язык: Английский

---

Functional modulation of the human gut microbiome by bacteria vehicled by cheese

Applied and Environmental Microbiology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

ABSTRACT Since cheese is one of the most commonly and globally consumed fermented foods, scientific investigations in recent decades have focused on determining impact this dairy product human health well-being. However, modulatory effect exerted by autochthonous microbial community taxonomic composition associated functional potential gut microbiota still far from being fully dissected or understood. Here, through use an vitro gut-simulating cultivation model combination with multi-omics approaches, we shown that minor rather than dominant bacterial players are responsible for modulation consumers. These include taxa genera Enterococcus , Bacillus Clostridium, Hafnia . Indeed, they contribute to expand intestinal ecosystem introducing genes production metabolites relevant biological activity, including involved synthesis vitamins, short-chain fatty acids, amino acids. Furthermore, tracing microbiota-associated strains fecal samples consumers provided evidence horizontal transmission events, enabling detection particular transferred humans. Moreover, transcriptomic metabolomic analyses a horizontally transmitted (cheese-to-consumer) strain, i.e., paralvei T10, cultivated environment-simulating medium, confirmed concept cheese-derived bacteria may arsenal consumer’s microbiota. This highlights biologically contributions food microbes acquired consumption health. IMPORTANCE Diet universally recognized as primary factor influencing modulating both taxonomically functionally. In context, cheese, its own microbiota, serves not only source nourishment humans, but also nutrients Additionally, it act vehicle food-associated microorganisms which undergo transfer consumer, potentially host The current study can be traced repertoire significant implications

Язык: Английский

---

Postbiotics in inflammatory bowel disease: efficacy, mechanism, and therapeutic implications

Journal of the Science of Food and Agriculture, Год журнала: 2024, Номер unknown

Опубликована: Июль 15, 2024

Inflammatory bowel disease (IBD) is one of the most challenging diseases in 21st century, and more than 10 million people around world suffer from IBD. Because limitations adverse effects associated with conventional IBD therapies, there has been increased scientific interest microbial-derived biomolecules, known as postbiotics. Postbiotics are defined preparation inanimate microorganisms and/or their components that confer a health benefit on host, comprising inactivated microbial cells, cell fractions, metabolites, etc. have shown potential enhancing treatment by reducing inflammation, modulating immune system, stabilizing intestinal flora maintaining integrity barriers. Consequently, they considered promising adjunctive therapies for Recent studies indicate postbiotics offer distinctive advantages, including spanning clinical (safe origin), technological (easy storage transportation) economic (reduced production costs) dimensions, rendering them suitable widespread applications functional food/pharmaceutical. This review offers comprehensive overview definition, classification postbiotics, an emphasis biological activity both prevention © 2024 Society Chemical Industry.

Язык: Английский

---

The Role of Gut Microbiota in the Onset and Progression of Obesity and Associated Comorbidities

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12321 - 12321

Опубликована: Ноя. 16, 2024

Obesity, a global public health problem, is constantly increasing, so the concerns in preventing and combating it are increasingly focused on intestinal microbiota. It was found that microbiota different lean people compared to obese individuals, but exact mechanisms by which energy homeostasis influenced still incompletely known. Numerous studies show involvement of certain bacterial species promoting obesity associated diseases such as diabetes, hypertension, cancer, etc. Our aim summarize main findings regarding influence several factors lifestyle changes, including diet bariatric surgery, diversity gut individuals. The second purpose this paper investigate potential effect various modulation techniques ameliorating its comorbidities. A literature search conducted using PubMed database, identifying articles published between 2019 2024. Most identified suggest generally with alterations microbiome decreased microbial diversity, an increased Firmicutes-to-Bacteroidetes ratio, SCFAs levels. also indicate could represent novel strategy treating related metabolic diseases. Although some (e.g., inflammation or hormonal regulation) already considered powerful connection development, further research needed enhance knowledge particular topic.

Язык: Английский

---

The Promising Biological Role of Postbiotics in Treating Human Infertility

Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

Язык: Английский

---

Lactiplantibacillus plantarum ameliorated the negative effects of a low-protein diet on growth performance, antioxidant capacity, immune status, and gut microbiota of laying chicks

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Фев. 5, 2025

This experiment was conducted to investigate the effects of adding Lactiplantibacillus plantarum a low-protein diet on growth performance, ability immune status, and intestinal microbiota 0–21-day-old layer chickens. A total 180 one-day-old healthy Hy-line brown laying chicks were randomly divided into three groups with replicates each 20 chicks. The control group fed basal containing 19% protein, (LP) 17% probiotic (LPL) protein supplemented L. (1.0 × 10 9 CFU/kg). antioxidant capacity, gut chickens detected. We found that supplementation increased activities superoxide dismutase (SOD) glutathione peroxidase (GSH-Px), capacity (T-AOC), levels immunoglobulin (Ig) A, IgG, interleukin-10 (IL-10) in serum +1.0 CFU/kg compared (control). Furthermore, liver index, GSH-Px T-AOC activity serum, changed microflora structure, diversity, polyketose unit bioanabolic metabolism (LP). In conclusion, could compensate for adverse diets chicks, combination is feasible way reduce diet.

Язык: Английский

---