Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering

Artificial Cells Nanomedicine and Biotechnology, Год журнала: 2017, Номер 46(4), С. 691 - 705

Опубликована: Июль 12, 2017

The tissue engineering field has developed in response to the shortcomings related replacement of tissues lost disease or trauma: donor rejection, chronic inflammation and shortages. driving force behind is avoid mentioned issues by creating biological substitutes capable replacing damaged tissue. This done combining scaffolds, cells signals order create living, physiological, three-dimensional tissues. A wide variety skin are used treatment full-thickness injuries. Substitutes made from can harbour latent viruses, artificial grafts heal with extensive scarring, failing regenerate structures such as glands, nerves hair follicles. New practical scaffold materials remain be developed. current article describes important information about wound healing scaffolds. types which were these fields classified according accepted guideline medicine. Moreover, present gave brief overview on fundamentals engineering, biodegradable polymer properties their application healing. Also, review discusses type engineered modern dressings promote

Язык: Английский

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Fabrication of polymeric biomaterials: a strategy for tissue engineering and medical devices

Journal of Materials Chemistry B, Год журнала: 2015, Номер 3(42), С. 8224 - 8249

Опубликована: Янв. 1, 2015

Polymeric biomaterials have a significant impact in today's health care technology. Polymer hydrogels were the first experimentally designed for human use. In this article design, synthesis and properties of hydrogels, derived from synthetic natural polymers, their use as tissue engineering are reviewed. The stimuli-responsive with controlled degradability examples suitable methods designing such biomaterials, using multidisciplinary approaches traditional polymer chemistry, materials to molecular biology, been discussed. Examples fabrication polymer-based utilized various cell type manipulations re-generation also elaborated. Since highly porous three-dimensional scaffold is crucially important cellular process, engineering, recent advances effective described. Additionally, incorporation factor molecules enhancement formation release elucidated article. Finally, future challenges efficient polymeric regeneration medical device applications

Язык: Английский

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Electrospinning of natural polymers for advanced wound care: towards responsive and adaptive dressings

Journal of Materials Chemistry B, Год журнала: 2016, Номер 4(28), С. 4801 - 4812

Опубликована: Янв. 1, 2016

In the last few years, health-care services have registered worldwide an increased number of patients suffering from chronic wounds and ulcers, which are mainly associated with diabetes, obesity cancer. The need for regenerating rapidly effectively injured skin has stimulated research advanced therapies wound care. This review will discuss how biomimetic architectures produced by electrospinning natural biopolymers fulfil most requirements ideal dressings. It also examine recent progress in area portable systems multiscale instructive materials that integrate stimuli responsive sensing elements.

Язык: Английский

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Polysaccharide-Based Conjugates for Biomedical Applications

Bioconjugate Chemistry, Год журнала: 2015, Номер 26(8), С. 1396 - 1412

Опубликована: Июнь 24, 2015

Polysaccharides contain different functional groups (such as hydroxyl, amino, carboxylic acid, aldehydes) that make them ideal for conjugation. They are biodegradable, biocompatible, and hydrophilic. Polysaccharide conjugates have been used in drug, gene, macromolecule delivery, tissue engineering, other biomedical applications. also primarily solubilization controlled release of hydrophobic moieties. The advent nanotechnology, gene therapy, engineering influenced the way these now used. Modern day modulated to be thermoresponsive, pH-responsive, photoresponsive, or target-specific (receptor mediated targeting). This Review briefly introduces polysaccharides followed by synthetic strategies conjugation; finally, recent applications were compiled.

Язык: Английский

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Fabrication challenges and trends in biomedical applications of alginate electrospun nanofibers

Carbohydrate Polymers, Год журнала: 2019, Номер 228, С. 115419 - 115419

Опубликована: Окт. 1, 2019

Язык: Английский

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Synthesis of cellulose acetate and carboxymethylcellulose from sugarcane straw

Carbohydrate Polymers, Год журнала: 2016, Номер 152, С. 679 - 686

Опубликована: Июль 19, 2016

Язык: Английский

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Chitosan: An undisputed bio-fabrication material for tissue engineering and bio-sensing applications

International Journal of Biological Macromolecules, Год журнала: 2018, Номер 110, С. 110 - 123

Опубликована: Янв. 13, 2018

Язык: Английский

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Borrowing From Nature: Biopolymers and Biocomposites as Smart Wound Care Materials

Frontiers in Bioengineering and Biotechnology, Год журнала: 2018, Номер 6

Опубликована: Окт. 2, 2018

Wound repair is a complex and tightly regulated physiological process, involving the activation of various cell types throughout each subsequent step (homeostasis, inflammation, proliferation, tissue remodeling). Any impairment within correct sequence healing events could lead to chronic wounds, with potential effects on patience quality life, consequent fallouts wound care management. Nature itself can be inspiration for development fully biodegradable materials, presenting enhanced bioactive potentialities, sustainability. Naturally-derived biopolymers are nowadays considered smart materials. They provide versatile tunable platform design appropriate extracellular matrix able support regeneration, while contrasting onset adverse events. In past decades, fabrication materials based natural polymers, either protein derivation or polysaccharide-based, has been extensively exploited tackle wound-healing related problematics. However, in today’s World exclusive use such becoming an urgent challenge, meet demand environmentally sustainable technologies our future needs, including applications fields healthcare following, we will briefly introduce main physico-chemical biological properties some protein-based naturally-derived polysaccharides. Moreover, present recent technological processing green approaches novel composite these biopolymers, particular attention their skin field. Lastly, highlight promising perspectives new generation environmentally-friendly, naturally-derived, dressings.

Язык: Английский

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Sources, Extraction and Biomedical Properties of Polysaccharides

Foods, Год журнала: 2019, Номер 8(8), С. 304 - 304

Опубликована: Авг. 1, 2019

In the recent era, bioactive compounds from plants have received great attention because of their vital health-related activities, such as antimicrobial activity, antioxidant anticoagulant anti-diabetic UV protection, antiviral hypoglycemia, etc. Previous studies already shown that polysaccharides found in are not likely to be toxic. Based on these inspirational comments, most research focused isolation, identification, and bioactivities polysaccharides. A large number biologically active been isolated with varying structural biological activities. this review, a comprehensive summary is provided developments physical chemical properties well activities important natural sources, wheat bran, orange peel, barely, fungi, algae, lichen, This review also biomedical applications The contents presented will useful reference for future extraction application therapeutic agent.

Язык: Английский

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Recent advances in polysaccharides based biomaterials for drug delivery and tissue engineering applications

Carbohydrate Polymer Technologies and Applications, Год журнала: 2021, Номер 2, С. 100067 - 100067

Опубликована: Апрель 14, 2021

In this paper, a spotlight is shown on polysaccharides based biomaterials which have surfaced as versatile platform for different biomedical applications including drug delivery and tissue regeneration. Herein, structure unique properties of are described along with various functionalization strategies. Additionally, brief overview physical chemical crosslinking approaches to design derived provided. Due their inherent biocompatible biodegradable properties, being extensively explored performing difficult task under complex biological environment. Hence, recent developments in using functional especially engineering here. The studies reviewed here motivate fabricate novel outstanding functionality. Finally, future possibilities achieve widespread commercial use discussed.

Язык: Английский

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