Smart hydrogel for biomedical applications: TRIZ patent literature review

Journal of Chemical Technology & Biotechnology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Abstract Smart hydrogels are widely used in biomedical applications, including drug delivery, tissue engineering and biosensing, due to their ability respond stimuli such as pH, temperature biochemical signals. However, challenges scalability, cost biocompatibility limit broader adoption. The theory of inventive problem solving–patent literature review (TRIZ‐PLR) provides a structured methodology analyse patents, identify technological gaps propose innovative solutions. This study applies TRIZ‐PLR hydrogel revealing trends multi‐responsive 4D‐printed hydrogels. Comparative analysis fabrication methods highlights advantages limitations, demonstrating TRIZ‐PLR's role optimising material selection, enhancing scalability improving therapeutic efficacy. Case studies illustrate the integration AI‐driven design, bio‐inspired materials sustainable production strategies enhance applications. findings suggest that facilitates innovation by resolving contradictions, enabling more efficient cost‐effective Future research should focus on leveraging smart materials, artificial intelligence design principles performance adaptability. By applying insights, researchers can accelerate transition technologies from laboratory real‐world medical © 2025 Society Chemical Industry (SCI).

Язык: Английский

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Photoresponsive Hydrogels for Tissue Engineering

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(6), С. 3612 - 3630

Опубликована: Май 30, 2024

Hydrophilic and biocompatible hydrogels are widely applied as ideal scaffolds in tissue engineering. The "smart" gelation material can alter its structural, physiochemical, functional features answer to various endo/exogenous stimuli better biomimic the endogenous extracellular matrix for engineering of cells tissues. Light irradiation owns a high spatial-temporal resolution, complete biorthogonal reactivity, fine-tunability thus induce physiochemical reactions within photoresponsive with good precision, efficiency, safety. Both gel structure (e.g., geometry, porosity, dimension) performance (like conductivity thermogenic or mechanical properties) hence be programmed on-demand yield biochemical biophysical signals regulating morphology, growth, motility, phenotype engineered Here we summarize strategies mechanisms encoding light-reactivity into hydrogel demonstrate how fantastically such responsive gels change their properties light desired improve applications including cargo delivery, dynamic three-dimensional cell culture, repair regeneration, aiming provide basis more translation clinic.

Язык: Английский

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Bio-orthogonal tuning of matrix properties during 3D cell culture to induce morphological and phenotypic changes

Nature Protocols, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

Язык: Английский

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Dual release scaffolds as a promising strategy for enhancing bone regeneration: an updated review

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Янв. 31, 2025

Advancements in tissue regeneration, particularly bone regeneration is key area of research due to potential novel therapeutic approaches. Efforts reduce reliance on autologous and allogeneic grafts have led the development biomaterials that promote synchronized controlled healing. However, use growth factors limited by their short half-life, slow penetration, large molecular size toxicity. These suggest traditional delivery methods may be inadequate hence, address these challenges, new strategies are being explored. approaches include bioactive substances within advanced systems enable precise spatiotemporal control. Dual-release composite scaffolds offer a promising solution reducing need for multiple surgical interventions simplifying treatment process. allow sustained drug release, enhancing repair while minimizing drawbacks conventional methods. This review explores various dual-drug release systems, discussing modes action, types drugs used mechanisms improve regeneration.

Язык: Английский

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Properties of acrylate hydrogel nano-oil emulsions with long hydrophobic chain segments

Journal of Physics Conference Series, Год журнала: 2025, Номер 2961(1), С. 012030 - 012030

Опубликована: Фев. 1, 2025

Abstract Hydrogels with rich water content and three-dimensional network structure have broad development prospects in biomedical fields such as drug delivery cell culture. Polyacrylate (PA) materials can induce innate immunity to play a regulatory role, polyacrylates hydrophobic chain segments enhance the cytocompatibility of polymers. In this study, different segment lengths were prepared, PA was immersed pure form acrylate hydrogel (AH). The micromorphology AH observed, its rotational viscosity light transmittance analyzed. long-term storage stability polyacrylate nano-oil emulsion (PNOE) obtained by mixing examined at 4°C 37°C, it found that more favorable for preservation emulsion. addition, subcutaneous injection PNOE BABL/c mice used characterize safety immunization, good profile, which is an important prerequisite use vaccine adjuvant.

Язык: Английский

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Current research progress of smart hydrogels in wound healing – a review

International Journal of Polymeric Materials, Год журнала: 2025, Номер unknown, С. 1 - 20

Опубликована: Май 21, 2025

Язык: Английский

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Pumpkin Oil/MgO—(Hydroxyethyl Cellulose‐Acrylamide) Nanocomposite Hydrogels as Potential Wound Dressings: Radiation Synthesis, Characterization, and Biological Appraisals

Polymers for Advanced Technologies, Год журнала: 2025, Номер 36(6)

Опубликована: Май 29, 2025

ABSTRACT Gamma‐irradiation technology for crosslinking and sterilization was used the synthesis of novel bioactive dressings based on hydroxyethyl cellulose (HEC), acrylamide (AAm), carbopol (Cp), supplemented with MgO NPs pumpkin oil (PKO). were synthesized using precipitation method characterized XRD, EDX, FTIR analysis. The TEM technique confirmed development cubic an average size between 28 52 nm. Incorporating slightly decreases gelation degree enhances water uptake. fluid absorption capacity PKO‐(HEC‐AAm‐Cp)‐MgO enhanced found in following order: > saline PECF 24 h. showed adequate porosity moisture retention rate. PKO‐(HEC‐AAm‐Cp)‐7% nanocomposite demonstrate efficient antimicrobial activity against Staphylococcus aureus , Klebsiella pneumoniae Candida albicans . MTT assay biocompatibility dressings. effectiveness wound healing assessed a rat model. wounded groups treated faster improved biochemical parameters histological assessment than control group. STAT3, PDGF, FGF, miR‐31 significant increase day 14 7 ( p < 0.05). These findings that have promising potential as treatment candidates.

Язык: Английский

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Biomacromolecular hydrogel scaffolds from microfluidics for cancer therapy: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 136738 - 136738

Опубликована: Окт. 20, 2024

Язык: Английский

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Synthesis and Comprehensive Characterization of PVA/Chitosan/Cu Nanowires Wound Dressing Hydrogel for Effective In Vitro Wound Healing

Journal of Industrial and Engineering Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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