Journal of Industrial and Engineering Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(6), P. 3612 - 3630
Published: May 30, 2024
Hydrophilic and biocompatible hydrogels are widely applied as ideal scaffolds in tissue engineering. The "smart" gelation material can alter its structural, physiochemical, functional features answer to various endo/exogenous stimuli better biomimic the endogenous extracellular matrix for engineering of cells tissues. Light irradiation owns a high spatial-temporal resolution, complete biorthogonal reactivity, fine-tunability thus induce physiochemical reactions within photoresponsive with good precision, efficiency, safety. Both gel structure (e.g., geometry, porosity, dimension) performance (like conductivity thermogenic or mechanical properties) hence be programmed on-demand yield biochemical biophysical signals regulating morphology, growth, motility, phenotype engineered Here we summarize strategies mechanisms encoding light-reactivity into hydrogel demonstrate how fantastically such responsive gels change their properties light desired improve applications including cargo delivery, dynamic three-dimensional cell culture, repair regeneration, aiming provide basis more translation clinic.
Language: Английский
Citations
6
Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18
Published: Jan. 31, 2025
Advancements in tissue regeneration, particularly bone regeneration is key area of research due to potential novel therapeutic approaches. Efforts reduce reliance on autologous and allogeneic grafts have led the development biomaterials that promote synchronized controlled healing. However, use growth factors limited by their short half-life, slow penetration, large molecular size toxicity. These suggest traditional delivery methods may be inadequate hence, address these challenges, new strategies are being explored. approaches include bioactive substances within advanced systems enable precise spatiotemporal control. Dual-release composite scaffolds offer a promising solution reducing need for multiple surgical interventions simplifying treatment process. allow sustained drug release, enhancing repair while minimizing drawbacks conventional methods. This review explores various dual-drug release systems, discussing modes action, types drugs used mechanisms improve regeneration.
Language: Английский
Citations
0
Journal of Physics Conference Series, Journal Year: 2025, Volume and Issue: 2961(1), P. 012030 - 012030
Published: Feb. 1, 2025
Abstract Hydrogels with rich water content and three-dimensional network structure have broad development prospects in biomedical fields such as drug delivery cell culture. Polyacrylate (PA) materials can induce innate immunity to play a regulatory role, polyacrylates hydrophobic chain segments enhance the cytocompatibility of polymers. In this study, different segment lengths were prepared, PA was immersed pure form acrylate hydrogel (AH). The micromorphology AH observed, its rotational viscosity light transmittance analyzed. long-term storage stability polyacrylate nano-oil emulsion (PNOE) obtained by mixing examined at 4°C 37°C, it found that more favorable for preservation emulsion. addition, subcutaneous injection PNOE BABL/c mice used characterize safety immunization, good profile, which is an important prerequisite use vaccine adjuvant.
Language: Английский
Citations
0
Journal of Chemical Technology & Biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
Abstract Smart hydrogels are widely used in biomedical applications, including drug delivery, tissue engineering and biosensing, due to their ability respond stimuli such as pH, temperature biochemical signals. However, challenges scalability, cost biocompatibility limit broader adoption. The theory of inventive problem solving–patent literature review (TRIZ‐PLR) provides a structured methodology analyse patents, identify technological gaps propose innovative solutions. This study applies TRIZ‐PLR hydrogel revealing trends multi‐responsive 4D‐printed hydrogels. Comparative analysis fabrication methods highlights advantages limitations, demonstrating TRIZ‐PLR's role optimising material selection, enhancing scalability improving therapeutic efficacy. Case studies illustrate the integration AI‐driven design, bio‐inspired materials sustainable production strategies enhance applications. findings suggest that facilitates innovation by resolving contradictions, enabling more efficient cost‐effective Future research should focus on leveraging smart materials, artificial intelligence design principles performance adaptability. By applying insights, researchers can accelerate transition technologies from laboratory real‐world medical © 2025 Society Chemical Industry (SCI).
Language: Английский
Citations
0
Nature Protocols, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 5, 2024
Language: Английский
Citations
3
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136738 - 136738
Published: Oct. 20, 2024
Language: Английский
Citations
2
Journal of Industrial and Engineering Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
1