Tailoring supramolecular antimicrobial peptides: from self-assembled nanoarchitectures to activities
Science China Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Язык: Английский
Bioactive Hydrogels (Bio‐HyGs): Emerging Trends in Drug Delivery and Wound Healing Applications
Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(4)
Опубликована: Март 31, 2025
ABSTRACT
This
review
on
bioactive
Hydrogels
(Bio‐HyGs)
synthesizes
current
advancements
in
their
design
and
utilization,
particularly
emphasizing
roles
drug
delivery
wound
healing.
Bio‐HyGs,
including
gelatin
methacrylate
(GM),
polyethylene
glycol
(PEG),
poly(vinyl
alcohol)
(PVA),
are
highlighted
for
effectiveness
treating
chronic
wounds
like
diabetic
pressure
ulcers,
leveraging
moisture
retention
tissue
regeneration
capabilities.
These
hydrogels
designed
the
controlled
release
of
compounds
such
as
vascular
endothelial
growth
factor
(VEGF)
platelet‐derived
(PDGF),
thereby
facilitating
healing
without
need
initial
cell
seeding.
The
also
covers
embedded
with
antimicrobial
agents
silver
nanoparticles
quaternized
chitosan,
which
crucial
managing
infected
wounds.
Additionally,
thermoresponsive
that
respond
to
temperature
changes
application
self‐assembling
peptides
3D
printing
discussed
contributions
mimicking
biological
tissues,
enhance
both
aims
provide
a
comprehensive
understanding
structural
functional
modifications
exploring
potential
transforming
clinical
outcomes
treatment
systems.
Язык: Английский
Multidimensional exploration of hydrogels as biological scaffolds for spinal cord regeneration: mechanisms and future perspectives
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Апрель 23, 2025
Spinal
cord
injury
(SCI)
is
a
severe
condition
that
frequently
leads
to
permanent
disabilities
and
neurological
dysfunction.
Its
progression
driven
by
multifaceted
pathophysiology,
encompassing
direct
trauma,
secondary
cascades,
intricate
cellular
molecular
responses.
While
current
therapies
focus
on
alleviating
symptoms
restoring
functionality,
achieving
effective
neural
regeneration
in
the
spinal
continues
be
significant
challenge.
Hydrogels,
recognized
for
their
exceptional
biocompatibility,
conductivity,
injectability,
have
shown
great
potential
as
advanced
scaffolds
support
neuronal
axonal
regeneration.
Recently,
these
materials
attracted
interest
field
of
SCI
rehabilitation
research.
This
review
concludes
recent
progress
hydrogel-based
strategies
rehabilitation,
emphasizing
distinct
properties,
underlying
mechanisms,
integration
with
bioactive
molecules,
stem
cells,
complementary
biomaterials.
Hydrogels
foster
providing
tailored
microenvironment,
while
features
such
self-repair,
electrical
controlled
drug
release
significantly
enhance
therapeutic
experimental
models.
explores
hydrogel
technologies
applications,
underscoring
address
challenges
treatment
paving
way
future
clinical
implementation.
Язык: Английский
Bioactive Hydrogels Inspired by Laminin: An Emerging Biomaterial for Tissue Engineering Applications
Macromolecular Bioscience,
Год журнала:
2024,
Номер
24(11)
Опубликована: Авг. 22, 2024
Abstract
Tissue
or
organ
damage
due
to
severe
injuries
chronic
diseases
can
adversely
affect
the
quality
of
life.
Current
treatments
rely
on
tissue
transplantation
which
has
limitations
including
unavailability
donors,
ethical
issues,
immune
rejection
after
transplantations.
These
be
addressed
by
regeneration
involves
development
bioactive
scaffolds
closely
mimicking
extracellular
matrix
(ECM).
One
major
components
ECM
is
laminin
protein
supports
several
tissues
associated
with
important
organs.
In
this
direction,
peptide‐based
hydrogels
effectively
mimic
essential
characteristics
laminin.
While
reports
have
discussed
structure
laminin,
potential
laminin‐derived
peptide
as
effective
biomaterial
for
engineering
applications
yet
discussed.
context,
current
review
focuses
and
its
role
an
protein.
Further,
short
in
crucial
properties
proposed.
The
further
highlights
significance
inspired
–
addressing
numerous
angiogenesis,
neural,
skeletal
muscle,
liver,
adipose
along
a
brief
outlook
future
these
laminin‐based
hydrogels.
Язык: Английский
Chemical materials involved in neural tissue engineering scaffold techniques: a narrative review
Advanced technology in neuroscience .,
Год журнала:
2024,
Номер
1(2), С. 244 - 260
Опубликована: Ноя. 27, 2024
Nerve
injury
often
leads
to
degeneration
or
necrosis
of
damaged
nerve
cells,
which
can
result
in
regeneration
disorders
during
the
repair
process.
Promoting
is
a
critical
challenge
treatment
nervous
system
diseases.
With
rapid
advancements
related
research,
chemical
materials
have
shown
significant
promise
facilitating
because
their
excellent
biocompatibility
and
degradability.
The
use
tissue-engineered
material
scaffolds
provide
physical
channels
for
regeneration.
These
create
optimal
conditions
cell
growth
migration
effectively
regulate
physiological
processes
repair.
Therefore,
wide
range
applications
field
This
review
highlights
technological
tools
available
involving
materials.
(1)
Conductive
hydrogels:
Novel
conductive
hydrogels
been
developed
by
integrating
such
as
graphene,
carbon
nanotubes,
polypyrrole,
promote
functional
recovery
cells
through
electrical
stimulation.
(2)
Three-dimensional
printing:
printing
technology
contributes
precise
control
shape,
porosity
degradation
rate
scaffolds,
providing
customized
microenvironment
(3)
Nanomaterials:
unique
physicochemical
properties
nanoparticles
nanofibers
give
them
great
potential
penetrate
blood‒brain
barrier,
guide
targeted
drug
delivery.
(4)
Local
release
bioactive
molecules:
Through
design
materials,
controlled
molecules
factor,
brain-derived
neurotrophic
factor
fibroblast
has
realized,
promotes
(5)
Photothermal
photoacoustic
stimulation:
combination
photothermal
technologies
led
development
capable
responding
photostimulation,
new
avenues
noninvasive
neurostimulation.
engineering
are
highly
effective
promoting
significantly
improve
efficiency
quality
In
clinical
practice,
these
techniques
expected
more
strategies
patients
with
injuries,
improving
function
life.
also
discusses
detail
different
biocompatibility,
mechanical
strength,
degradability,
A
variety
neural
tissue
scaffold
techniques,
including
provision
support,
molecules,
direct
interaction
cells.
Although
show
potential,
several
challenges,
long-term
stability,
individual
variation
response,
large-scale
production,
still
need
be
addressed
before
they
translated
into
applications.
addition,
comprehensive
assessment
safety
efficacy
focus
future
research.
Future
research
will
on
optimizing
conducting
trials
validate
techniques.
Язык: Английский