Injectable Hydrogels: In-Situ Tissue Engineering Strategies for Cartilage Repair and Regeneration DOI
Yuxin Huang, Yitian Gao,

Zeyuan Gao

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 26, 2025

Repairing chondral defects remains challenging due to the avascular and acellular nature of cartilage. Advances in tissue engineering based on hydrogels offer significant potential for high-quality chondrogenesis, with injectable emerging as a prominent area research, because they meet requirements minimally invasive administration. This review provides an overview recent progress cartilage repair regeneration summarizes synthesis strategies. We specifically focused key challenges including gelation techniques, robust bioadhesion, bioactive functionalization, which are primary obstacles achieving superior studies. By exploring current strategies address these their underlying mechanism, we aim inspire continuous advancements promoting application regeneration.

Язык: Английский

Naturally derived hydrogels for wound healing DOI
Duy Toàn Phạm, Nguyễn Thị Thủy, Nguyễn Thị Phương Thảo

и другие.

Therapeutic Delivery, Год журнала: 2025, Номер unknown, С. 1 - 15

Опубликована: Янв. 27, 2025

Natural hydrogels have garnered increasing attention due to their natural origins and beneficial roles in wound healing. Hydrogel water-retaining capacity excellent biocompatibility create an ideal moist environment for healing, thereby enhancing cell proliferation tissue regeneration. For this reason, naturally derived formulated from biomaterials such as chitosan, alginate, gelatin, fibroin are highly promising biodegradability low immunogenic responses. Recent integrated approaches utilizing new technologies with bioactive agents significantly improved the mechanical properties of controlled release delivery active compounds, efficiency treatment processes. Herein, review highlights advantages challenges focusing on strength, degradation rates, safety validation, potential incorporating advanced engineering gene therapy utilization personalized medicine.

Язык: Английский

Процитировано

3

Synthetic Polymers for Drug, Gene, and Vaccine Delivery DOI Creative Commons
Yajun Xu, Jie Chen, Jianxun Ding

и другие.

Polymer science & technology., Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Язык: Английский

Процитировано

1

Sodium alginate/chitosan composite scaffold reinforced with biodegradable polyesters/gelatin nanofibers for cartilage tissue engineering DOI
Chenxi Li, Wenbin Shang, Yuzhe Huang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138054 - 138054

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

7

Injectable Hydrogels: In-Situ Tissue Engineering Strategies for Cartilage Repair and Regeneration DOI
Yuxin Huang, Yitian Gao,

Zeyuan Gao

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Май 26, 2025

Repairing chondral defects remains challenging due to the avascular and acellular nature of cartilage. Advances in tissue engineering based on hydrogels offer significant potential for high-quality chondrogenesis, with injectable emerging as a prominent area research, because they meet requirements minimally invasive administration. This review provides an overview recent progress cartilage repair regeneration summarizes synthesis strategies. We specifically focused key challenges including gelation techniques, robust bioadhesion, bioactive functionalization, which are primary obstacles achieving superior studies. By exploring current strategies address these their underlying mechanism, we aim inspire continuous advancements promoting application regeneration.

Язык: Английский

Процитировано

0