Enhancing Radiotherapy Tolerance With Papaya Seed‐Derived Nanoemulsions

Food Science & Nutrition, Год журнала: 2025, Номер 13(4)

Опубликована: Апрель 1, 2025

ABSTRACT Flavonoid‐rich plant materials have gained attention for their potential to reduce radiotherapy side effects. Carica papaya (CP) seeds, known high flavonoid content, hold promise therapeutic applications. This study explored the extraction and evaluation of two oils—sunflower oil‐based oil (SPO) pure (PPO)—and nano emulsions (SPOE PPOE), derived from CP radioprotective Chemical analysis using QTOF‐MS revealed antioxidants phytochemicals in oils emulsions. Size zeta measurements dynamic light scattering (DLS) showed particle sizes 140 ± 26.06 nm PPOE 293.7 49.42 SPOE. Post‐radiation, both SPOE significantly enhanced cell viability, with values 72.24 3.92 ( p ≤ 0.001) 75.85 2.62 0.001), respectively. These nanoemulsions show as topical agents reducing radiation‐induced tissue damage radiotherapy. Despite promising vitro findings, further vivo studies are needed confirm clinical relevance these nanoemulsions. Additionally, incorporation into sunscreen formulations could provide protection against skin damage, broadening

Язык: Английский

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In Vitro Behavior of Boron‐Doped Baghdadite/Poly(vinylidene fluoride) Membrane Scaffolds Produced via Non‐Solvent Induced Phase Separation

Macromolecular Bioscience, Год журнала: 2025, Номер unknown

Опубликована: Май 22, 2025

Abstract This study explores the potential of boron‐doped baghdadite (BAG) powders incorporated into poly(vinylidene fluoride) (PVDF)‐based membrane scaffolds for bone tissue engineering applications. The aim is to enhance scaffolds’ microstructure, surface wettability, thermal behavior, mechanical properties, and biological performance. Composite are fabricated by integrating PVDF matrix, yielding with enhanced material characteristics functionality. incorporation significantly enhances hydrophilicity scaffolds, as evidenced a notable reduction in contact angle measurements. Mechanical analyses demonstrate that addition BAG reduces tensile strength elongation at break attribute increased pore size, reduced crystallinity, structural heterogeneity, though values remain within range human cancellous bone. Furthermore, vitro bioactivity studies reveal superior apatite‐forming ability composite indicating their biomineralization. results cellular adhesion assays indicate an affinity proliferation cells on which indicative improved biocompatibility. In conclusion, developed PVDF‐based reinforce powders, show promise effective alternatives traditional graft materials, offering scalable versatile solutions regenerative medicine.

Язык: Английский

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Niosomes: A Revolution in Sustainable and Targeted Drug Delivery-Green Synthesis, Precision Medicine, and Beyond

Regenerative Engineering and Translational Medicine, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

Язык: Английский

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