Enhancing Radiotherapy Tolerance With Papaya Seed‐Derived Nanoemulsions

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(4)

Published: April 1, 2025

ABSTRACT Flavonoid‐rich plant materials have gained attention for their potential to reduce radiotherapy side effects. Carica papaya (CP) seeds, known high flavonoid content, hold promise therapeutic applications. This study explored the extraction and evaluation of two oils—sunflower oil‐based oil (SPO) pure (PPO)—and nano emulsions (SPOE PPOE), derived from CP radioprotective Chemical analysis using QTOF‐MS revealed antioxidants phytochemicals in oils emulsions. Size zeta measurements dynamic light scattering (DLS) showed particle sizes 140 ± 26.06 nm PPOE 293.7 49.42 SPOE. Post‐radiation, both SPOE significantly enhanced cell viability, with values 72.24 3.92 ( p ≤ 0.001) 75.85 2.62 0.001), respectively. These nanoemulsions show as topical agents reducing radiation‐induced tissue damage radiotherapy. Despite promising vitro findings, further vivo studies are needed confirm clinical relevance these nanoemulsions. Additionally, incorporation into sunscreen formulations could provide protection against skin damage, broadening

Language: Английский

Niosomes: A Revolution in Sustainable and Targeted Drug Delivery-Green Synthesis, Precision Medicine, and Beyond

Regenerative Engineering and Translational Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Language: Английский