This
work
addresses
a
study
of
PEG-derived
hydrogels
based
on
β-aminoacrylate
cross-links
and
obtained
by
amino-yne
click
chemistry,
using
β-aminoacrylate-based
model
molecule
as
reference.
The
pH-triggered
cleavage
the
bonds
was
monitored
confirming
not
only
release
conjugated
amine
but
also
formation
mixture
chemical
species
that
depends
acidity
medium.
Moreover,
overall
hydrogel
degradation
rates
were
able
to
be
adjusted
modifying
pH,
temperature,
polymer
concentration,
or
selected
linker
PEG
chains.
In
particular,
labile
nature
bond
confirmed
even
under
physiological
conditions
(pH
7.4,
37
°C),
leading
long-term
material
degradation.
recovery
after
demonstrated
at
both
acidic
mimicking
results
acquired
through
studies.
Achieving
the
ideal
replacement
for
robust
biological
tissues
requires
biocompatible
materials
with
a
nuanced
blend
of
characteristics,
including
organ
specific
toughness,
durability,
self-repairing
capability,
and
well-defined
structure.
Hydrogels,
structured
high
water
containing
3D-crosslinked
polymeric
networks,
present
promising
avenue
in
biomedical
applications
due
to
their
close
resemblance
natural
tissues.
However,
mechanical
performance
often
falls
short,
limiting
clinical
applications.
Recent
research
has
been
focused
on
developing
hydrogel
therapeutic
advancements
have
spurred
researchers
develop
hydrogels
having
acceptable
toughness.
While
it
is
now
possible
tailor
properties
synthetic
gels
mimic
those
tissues,
critical
aspects
such
as
biocompatibility
crosslinking
strategies
are
frequently
neglected.
This
review
scrutinizes
structural
techniques
designed
improve
toughness
hydrogels,
focusing
especially
innovative
efforts
integrate
these
enhancements
into
natural-based
hydrogels.
By
thoroughly
examining
methodologies,
sheds
light
complexities
strengthening
will
propose
valuable
insights
development
next-generation
tissue
substitutes.
Biomacromolecules,
Год журнала:
2024,
Номер
25(2), С. 1084 - 1095
Опубликована: Янв. 30, 2024
Benzaldehyde-conjugated
chitosan
(CH–CBA)
was
synthesized
by
a
coupling
reaction
between
(CH)
and
carboxybenzaldehyde
(CBA).
The
pH-sensitive
self-cross-linking
can
be
achieved
through
the
Schiff
base
reaction.
degree
of
substitution
(DS)
CH–CBA
controlled
at
1.4–12.7%
optimizing
pH
reagent
stoichiometry.
dynamic
linkages
conferred
strong
shear-thinning
self-healing
properties
to
hydrogels.
viscosity
2
wt/v
%
hydrogel
decreased
from
5.3
×
107
mPa·s
shear
rate
10–2
s–1
2.0
103
102
7.4.
exhibited
excellent
biocompatibility
in
vitro
vivo.
Moreover,
adhered
strongly
porcine
small
intestine,
colon,
cecum
samples,
comparable
commercial
fibrin
glue,
effective
vivo
tissue
sealing
mouse
cecal
ligation
puncture
model,
highlighting
its
potential
as
biomaterial
for
application
adhesives,
engineering
scaffolds,
etc.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(19)
Опубликована: Март 21, 2024
Abstract
Dynamic
covalent
bond
hydrogels
have
demonstrated
significant
application
potential
in
biomedical
fields
for
their
dynamic
reversibility.
However,
the
contradiction
between
stability
and
dynamics
of
hydrogel
restricts
its
application.
Here,
utilizing
silver
sulfadiazine
(AgSD)
as
a
catalyst,
hyaluronic
acid‐based
are
constructed
through
imine
crosslinking
incorporated
disulfide
bonds
within
same
chain.
It
is
found
that
AgSD
can
accelerate
formation
to
improve
hydrogels,
thereby
shortening
gelation
time
by
≈36.9
times,
enhancing
compression
strength
adhesion
≈2.4
times
1.7
respectively,
while
inhibiting
swelling
degradation
rates
≈2.1
3.7
times.
Besides,
coordinate
with
enhance
hydrogel,
self‐healing
efficiency
≈2.3
reducing
relaxation
≈25.1
Significantly,
imparts
remarkable
antibacterial
properties
effectively
facilitating
healing
bacterial
infected
wounds.
Consequently,
introducing
enables
possess
concurrent
stability,
dynamics,
properties.
This
strategy
regulating
provides
valuable
reference
bonds.
Macromolecular Chemistry and Physics,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Abstract
The
field
of
materials
science
is
paramount
importance
in
the
solution
to
societal
issues,
including
energy,
environmental,
and
biomedical
problems.
Polymer
chemistry
a
leading
material
that
has
produced
number
practical
materials.
development
nanotechnology
for
control
ultrasmall
structures
interface
technology
organization
polymer
components
both
made
significant
contributions
this
field.
This
review,
entitled
“Nanoarchitectonics
Polymers
at
Interfaces,”
focuses
on
nanoarchitectonics
technologies
examine
recent
research
trends
design
functional
polymeric
Three
are
especially
considered:
i)
Langmuir–Blodgett
(LB)
technique,
which
allows
orientation
hybridization
polymers
interfaces;
ii)
layer‐by‐layer
(LbL)
assembly,
construction
rational
layered
from
other
materials;
iii)
on‐surface
synthesis,
uses
perform
surfaces.
final
section
review
discusses
necessary
future
directions
Interfaces”
based
these
examples.
