Amino-yne Reaction for the Synthesis of Degradable Hydrogels: Study of the Cleavage of β-Aminoacrylate Cross-Links DOI Creative Commons

Sara Bescós-Ramo,

Jesús del Barrio, Pilar Romero

и другие.

Macromolecules, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

This work addresses a study of PEG-derived hydrogels based on β-aminoacrylate cross-links and obtained by amino-yne click chemistry, using β-aminoacrylate-based model molecule as reference. The pH-triggered cleavage the bonds was monitored confirming not only release conjugated amine but also formation mixture chemical species that depends acidity medium. Moreover, overall hydrogel degradation rates were able to be adjusted modifying pH, temperature, polymer concentration, or selected linker PEG chains. In particular, labile nature bond confirmed even under physiological conditions (pH 7.4, 37 °C), leading long-term material degradation. recovery after demonstrated at both acidic mimicking results acquired through studies.

Язык: Английский

Self-healing hydrogels as injectable implants: Advances in translational wound healing DOI
Saadullah Khattak, Ihsan Ullah,

Hailin Xie

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 509, С. 215790 - 215790

Опубликована: Март 20, 2024

Язык: Английский

Процитировано

37

Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications DOI Creative Commons
Md. Mahamudul Hasan Rumon, Md. Sohanur Rahman, Anwarul Azim Akib

и другие.

Discover Materials, Год журнала: 2025, Номер 5(1)

Опубликована: Янв. 9, 2025

Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and well-defined structure. Hydrogels, structured high water containing 3D-crosslinked polymeric networks, present promising avenue in biomedical applications due to their close resemblance natural tissues. However, mechanical performance often falls short, limiting clinical applications. Recent research has been focused on developing hydrogel therapeutic advancements have spurred researchers develop hydrogels having acceptable toughness. While it is now possible tailor properties synthetic gels mimic those tissues, critical aspects such as biocompatibility crosslinking strategies are frequently neglected. This review scrutinizes structural techniques designed improve toughness hydrogels, focusing especially innovative efforts integrate these enhancements into natural-based hydrogels. By thoroughly examining methodologies, sheds light complexities strengthening will propose valuable insights development next-generation tissue substitutes.

Язык: Английский

Процитировано

12

Ways forward with conductive hydrogels: Classifications, properties, and applications in flexible electronic and energy gadgets DOI
Weilin Zhang, Hongjian Zhang, Hyunseung Kim

и другие.

Materials Science and Engineering R Reports, Год журнала: 2025, Номер 163, С. 100923 - 100923

Опубликована: Янв. 8, 2025

Язык: Английский

Процитировано

1

Injectable, Shear-Thinning, Self-Healing, and Self-Cross-Linkable Benzaldehyde-Conjugated Chitosan Hydrogels as a Tissue Adhesive DOI
Ching-Cheng Tsai, Arvind K. Singh Chandel,

Kento Mitsuhashi

и другие.

Biomacromolecules, Год журнала: 2024, Номер 25(2), С. 1084 - 1095

Опубликована: Янв. 30, 2024

Benzaldehyde-conjugated chitosan (CH–CBA) was synthesized by a coupling reaction between (CH) and carboxybenzaldehyde (CBA). The pH-sensitive self-cross-linking can be achieved through the Schiff base reaction. degree of substitution (DS) CH–CBA controlled at 1.4–12.7% optimizing pH reagent stoichiometry. dynamic linkages conferred strong shear-thinning self-healing properties to hydrogels. viscosity 2 wt/v % hydrogel decreased from 5.3 × 107 mPa·s shear rate 10–2 s–1 2.0 103 102 7.4. exhibited excellent biocompatibility in vitro vivo. Moreover, adhered strongly porcine small intestine, colon, cecum samples, comparable commercial fibrin glue, effective vivo tissue sealing mouse cecal ligation puncture model, highlighting its potential as biomaterial for application adhesives, engineering scaffolds, etc.

Язык: Английский

Процитировано

9

One Stone Three Birds: Silver Sulfadiazine Modulates the Stability and Dynamics of Hydrogels for Infected Wound Healing DOI
Ye Huang,

Haifei Kang,

Y.G. Wang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(19)

Опубликована: Март 21, 2024

Abstract Dynamic covalent bond hydrogels have demonstrated significant application potential in biomedical fields for their dynamic reversibility. However, the contradiction between stability and dynamics of hydrogel restricts its application. Here, utilizing silver sulfadiazine (AgSD) as a catalyst, hyaluronic acid‐based are constructed through imine crosslinking incorporated disulfide bonds within same chain. It is found that AgSD can accelerate formation to improve hydrogels, thereby shortening gelation time by ≈36.9 times, enhancing compression strength adhesion ≈2.4 times 1.7 respectively, while inhibiting swelling degradation rates ≈2.1 3.7 times. Besides, coordinate with enhance hydrogel, self‐healing efficiency ≈2.3 reducing relaxation ≈25.1 Significantly, imparts remarkable antibacterial properties effectively facilitating healing bacterial infected wounds. Consequently, introducing enables possess concurrent stability, dynamics, properties. This strategy regulating provides valuable reference bonds.

Язык: Английский

Процитировано

8

Molecular origin of pyrrolidone-based dynamic imine covalent copolymers on self-assembly and emulsification DOI
Han Bao,

Xianhai Liu,

Yan Xue

и другие.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136396 - 136396

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Imine-containing Self-healing Waterborne Polyurethane Elastomeric Coating Derived from Bio-based Polyester Polyol DOI
Ismail Omrani,

Morteza Safarzadeh Zarjani,

Reza Mohammadi Berenjegani

и другие.

Journal of Polymers and the Environment, Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

Язык: Английский

Процитировано

4

Bioprinting of transparent and adhesive corneal patches: Integrating photo-crosslinkable dopamine-conjugated silk fibroin and decellularized cornea matrix for sutureless tissue integration and regeneration DOI
Anwesha Ghosh, Ashis Kumar Bera, Jaideep Adhikari

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141761 - 141761

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Nanoarchitectonics of Polymers at Interfaces DOI Creative Commons
Katsuhiko Ariga

Macromolecular Chemistry and Physics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Abstract The field of materials science is paramount importance in the solution to societal issues, including energy, environmental, and biomedical problems. Polymer chemistry a leading material that has produced number practical materials. development nanotechnology for control ultrasmall structures interface technology organization polymer components both made significant contributions this field. This review, entitled “Nanoarchitectonics Polymers at Interfaces,” focuses on nanoarchitectonics technologies examine recent research trends design functional polymeric Three are especially considered: i) Langmuir–Blodgett (LB) technique, which allows orientation hybridization polymers interfaces; ii) layer‐by‐layer (LbL) assembly, construction rational layered from other materials; iii) on‐surface synthesis, uses perform surfaces. final section review discusses necessary future directions Interfaces” based these examples.

Язык: Английский

Процитировано

0

Deep Insights into the Design of Next-Generation Water-Based Stimuli-Responsive Shape Memory Polymers: From Fundamentals to Nature-Inspired Innovations DOI
Peerawat Prathumrat,

Chutiwat Likitaporn,

Sarawut Rimdusit

и другие.

Applied Materials Today, Год журнала: 2025, Номер 44, С. 102754 - 102754

Опубликована: Апрель 29, 2025

Язык: Английский

Процитировано

0