Antimicrobial peptide biological activity, delivery systems and clinical translation status and challenges

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Март 7, 2025

Antibiotic resistance is currently one of the most significant threats to global public health and safety. And studies have found that over next 25 years, 39 million people will die directly 169 indirectly due antibiotic-resistant diseases. Consequently, development new types antimicrobial drugs urgently needed. Antimicrobial peptides (AMPs) constitute an essential component innate immune response in all organisms. They exhibit a distinctive mechanism action endows them with broad spectrum biological activities, including antimicrobial, antibiofilm, antiviral, anti-inflammatory effects. However, AMPs also present certain limitations, such as cytotoxicity, susceptibility protein hydrolysis, poor pharmacokinetic properties, which impeded their clinical application. The delivery systems can address these challenges by modifying AMP enabling precise, controlled release at site infection or disease. This review offers comprehensive analysis mechanisms advantages AMPs. systematically evaluate how emerging drug systems, nanoparticles hydrogels, enhance stability bioavailability AMPs, discussing both strengths limitations. Moreover, unlike previous reviews, this highlight recent clinically approved AMP-based those development, emphasizing key translating into practice. With perspectives, it hoped provide some insights overcoming translational barriers advancing

Язык: Английский

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Biopolymer-based hydrogels for biomedical applications: Bioactivity and wound healing properties

Coordination Chemistry Reviews, Год журнала: 2024, Номер 518, С. 216093 - 216093

Опубликована: Июль 25, 2024

Язык: Английский

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Multifunctional self-healing and pH-responsive hydrogel dressing based on cationic guar gum and hyaluronic acid for on-demand drug release

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140326 - 140326

Опубликована: Янв. 1, 2025

Язык: Английский

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Calcium‐Capturing Hydrogel with Self‐Reinforced Multi‐Dynamic Networks for Effective Periodontal Bone Regeneration in Three‐Dimension

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Abstract Hydrogel scaffolds perform well for periodontal bone regeneration. However, due to lacking injectability, poor mechanical strength, and weak adhesive force, conventional hydrogels are difficult adapt irregular defects unable maintain stability under occlusal force. Consequently, the current approaches still present significant challenges in achieving intact 3D Herein, a calcium‐capturing self‐reinforcing hydrogel, composed of alendronate‐functionalized oxidized sodium alginate (OSA‐Alen), nano‐hydroxyapatite (HAP), dopamine‐grafted gelatin (Gel‐DA), is prepared The Schiff‐base reaction endows hydrogel with while dynamic coordination between OSA‐Alen HAP confers superior self‐healing ability homogeneous distribution HAP. Tissue adhesiveness from Gel‐DA enables within defect area. Furthermore, self‐reinforces mechanically by calcium ion (Ca 2+ ) capturing, providing supportive matrix regeneration, promoting osteogenesis Ca influx. Especially, via rat model, vivo examination displays regeneration directions (57.03% volume fraction achieved) after being treated injectable eight weeks. offers an alternative biomaterial presents profound potential repair peri‐implant loss near future.

Язык: Английский

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Injectable hydrogels for bioelectronics: A viable alternative to traditional hydrogels

Chemical Engineering Journal, Год журнала: 2024, Номер 495, С. 153391 - 153391

Опубликована: Июнь 22, 2024

Язык: Английский

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Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract Diabetes significantly impairs the body's wound‐healing capabilities, leading to chronic, infection‐prone wounds. These wounds are characterized by hyperglycemia, inflammation, hypoxia, variable pH levels, increased matrix metalloproteinase activity, oxidative stress, and bacterial colonization. complex conditions complicate effective wound management, prompting development of advanced diabetic care strategies that exploit specific characteristics such as acidic pH, high glucose stress trigger controlled drug release, thereby enhancing therapeutic effects dressings. Among solutions, hydrogels emerge promising due their stimuli‐responsive nature, making them highly for managing these The latest advancements in mono/multi‐stimuli‐responsive smart showcase superiority potential healthcare materials, highlighted relevant case studies. However, traditional dressings fall short meeting nuanced needs wounds, adjustable adhesion, easy removal, real‐time status monitoring, dynamic release adjustment according wound's conditions. Responsive represent a significant leap forward proficient sensing responding environment, offering more targeted approach treatment. This review highlights recent dressing, delivery, emphasizing role improving healing. It addresses ongoing challenges future directions, aiming guide clinical adoption.

Язык: Английский

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Nanoparticle-based drug delivery systems: An updated strategy for treating fungal keratitis

Colloids and Interface Science Communications, Год журнала: 2024, Номер 61, С. 100794 - 100794

Опубликована: Июль 1, 2024

Fungal keratitis is a globally blinding eye disease caused by fungi, with more than 1.05 million cases diagnosed annually, mainly in Asia. It the most common form of infectious keratitis, accounting for approximately 40–50% microbial cases. The difficult to treat and prognosis often poor. Conventional antimicrobial therapies, which are mainstay treatment, face problems off-target toxicity, low bioavailability, drug-resistant fungi. In recent years, novel drug delivery systems have emerged as promising alternative. These improve stability, extend residence time, control release, target specific tissues cells, reduce toxic side effects. Nanoparticle-based particularly compelling. aim this paper elucidate mechanisms advances nanoparticle-based antifungal therapy provide new perspectives on treatment fungal keratitis.

Язык: Английский

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Exploring the potential of polysaccharides-based injectable self-healing hydrogels for wound healing applications: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 137209 - 137209

Опубликована: Ноя. 4, 2024

Язык: Английский

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Herbal micelles-loaded ROS-responsive hydrogel with immunomodulation and microenvironment reconstruction for diabetic wound healing

Biomaterials, Год журнала: 2024, Номер 317, С. 123076 - 123076

Опубликована: Дек. 31, 2024

Язык: Английский

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In situ gels for postoperative cancer treatment: Current status and challenges

Chemical Engineering Journal, Год журнала: 2025, Номер 505, С. 159621 - 159621

Опубликована: Янв. 15, 2025

Язык: Английский

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