Advanced Engineering Materials,
Год журнала:
2023,
Номер
25(21)
Опубликована: Авг. 29, 2023
Stimuli‐responsive
polymers
(SRPs)
are
special
types
of
soft
materials,
which
have
been
extensively
used
for
developing
flexible
actuators,
robots,
wearable
devices,
sensors,
self‐expanding
structures,
and
biomedical
thanks
to
their
ability
change
shapes
functional
properties
in
response
external
stimuli
including
light,
humidity,
heat,
pH,
electric
field,
solvent,
magnetic
field
or
combinations
two
more
these
stimuli.
In
recent
years,
additive
manufacturing
(AM)
aka
3D
printing
technology
SRPs,
also
known
as
4D
printing,
has
gained
phenomenal
attention
different
engineering
fields,
its
unique
develop
complex,
personalized,
innovative
undergo
twisting,
elongating,
swelling,
rolling,
shrinking,
bending,
spiraling,
other
complex
morphological
transformations.
Herein,
an
effort
made
provide
insightful
information
about
the
AM
techniques,
type
applications
including,
but
not
limited
tissue
engineering,
bionics,
construction,
smart
textiles.
This
article
incorporates
current
challenges
prospects,
hoping
basis
utilization
this
fields.
It
is
expected
that
amalgamation
with
SRPs
would
unparalleled
advantages
arenas.
Molecules,
Год журнала:
2021,
Номер
26(19), С. 5905 - 5905
Опубликована: Сен. 29, 2021
The
drug
delivery
system
enables
the
release
of
active
pharmaceutical
ingredient
to
achieve
a
desired
therapeutic
response.
Conventional
systems
(tablets,
capsules,
syrups,
ointments,
etc.)
suffer
from
poor
bioavailability
and
fluctuations
in
plasma
level
are
unable
sustained
release.
Without
an
efficient
mechanism,
whole
process
can
be
rendered
useless.
Moreover,
has
delivered
at
specified
controlled
rate
target
site
as
precisely
possible
maximum
efficacy
safety.
Controlled
developed
combat
problems
associated
with
conventional
delivery.
There
been
tremendous
evolution
past
two
decades
ranging
macro
scale
nano
intelligent
targeted
initial
part
this
review
provides
basic
understanding
emphasis
on
pharmacokinetics
drug.
It
also
discusses
their
limitations.
Further,
discussed
detail
design
considerations,
classifications
drawings.
In
addition,
nano-drug
delivery,
smart
using
stimuli-responsive
biomaterials
is
recent
key
findings.
paper
concludes
challenges
faced
future
directions
Theranostics,
Год журнала:
2020,
Номер
10(10), С. 4557 - 4588
Опубликована: Янв. 1, 2020
In
recent
years,
much
progress
has
been
motivated
in
stimuli-responsive
nanocarriers,
which
could
response
to
the
intrinsic
physicochemical
and
pathological
factors
diseased
regions
increase
specificity
of
drug
delivery.
Currently,
numerous
nanocarriers
have
engineered
with
changes
responding
external
stimuli,
such
as
ultrasound,
thermal,
light
magnetic
field,
well
internal
including
pH,
redox
potential,
hypoxia
enzyme,
etc.
Nanocarriers
respond
stimuli
tumor
microenvironments
or
inside
cancer
cells
for
on-demanded
delivery
accumulation,
controlled
release,
activation
bioactive
compounds,
probes
targeting
ligands,
size,
charge
conformation
conversion,
etc.,
leading
sensing
signaling,
overcoming
multidrug
resistance,
accurate
diagnosis
precision
therapy.
This
review
summarized
general
strategies
developing
advances,
presented
their
applications
delivery,
imaging,
therapy
theranostics,
illustrated
clinical
translation
made
prospects.
Frontiers in Molecular Biosciences,
Год журнала:
2020,
Номер
7
Опубликована: Ноя. 26, 2020
The
use
of
nanoparticles
(NP)
in
diagnosis
and
treatment
many
human
diseases,
including
cancer,
is
increasing
interest.
However,
cytotoxic
effects
NPs
on
cells
the
uptake
efficiency
significantly
limit
their
clinical
practice.
physico-chemical
properties
surface
composition,
superficial
charge,
size
shape
are
considered
key
factors
that
affect
biocompatibility
these
nanoplatforms.
Thanks
to
possibility
modifying
NPs,
it
possible
improve
through
functionalization
NP
surface.
In
this
review,
we
summarize
some
most
recent
studies
which
modification
enhances
uptake.
Furthermore,
used
techniques
assess
also
reported.
Chemical Reviews,
Год журнала:
2021,
Номер
121(18), С. 11527 - 11652
Опубликована: Май 3, 2021
The
advent
of
genome
editing
has
transformed
the
therapeutic
landscape
for
several
debilitating
diseases,
and
clinical
outlook
gene
therapeutics
never
been
more
promising.
potential
nucleic
acids
limited
by
a
reliance
on
engineered
viral
vectors
delivery.
Chemically
defined
polymers
can
remediate
technological,
regulatory,
challenges
associated
with
modes
Because
their
scalability,
versatility,
exquisite
tunability,
are
ideal
biomaterial
platforms
delivering
acid
payloads
efficiently
while
minimizing
immune
response
cellular
toxicity.
While
polymeric
delivery
progressed
significantly
in
past
four
decades,
translation
vehicles
faces
formidable
challenges.
aim
our
Account
is
to
illustrate
diverse
concepts
designing
towards
meeting
goals
vivo
ex
therapy.
Here,
we
highlight
classes
employed
summarize
recent
work
understanding
contributions
chemical
architectural
design
parameters.
We
touch
upon
characterization
methods
used
visualize
understand
events
transpiring
at
interfaces
between
polymer,
acids,
physiological
environment.
conclude
that
interdisciplinary
approaches
methodologies
motivated
fundamental
questions
key
high-performing
Chemical Reviews,
Год журнала:
2021,
Номер
121(15), С. 9243 - 9358
Опубликована: Июль 20, 2021
Research
related
to
the
development
and
application
of
luminescent
nanoparticles
(LNPs)
for
chemical
biological
analysis
imaging
is
flourishing.
Novel
materials
new
applications
continue
be
reported
after
two
decades
research.
This
review
provides
a
comprehensive
heuristic
overview
this
field.
It
targeted
both
newcomers
experts
who
are
interested
in
critical
assessment
LNP
materials,
their
properties,
strengths
weaknesses,
prospective
applications.
Numerous
cataloged
by
fundamental
descriptions
identities
physical
morphology,
quantitative
photoluminescence
(PL)
PL
mechanisms,
surface
chemistry.
These
include
various
semiconductor
quantum
dots,
carbon
nanotubes,
graphene
derivatives,
nanodiamonds,
metal
nanoclusters,
lanthanide-doped
upconversion
downshifting
nanoparticles,
triplet–triplet
annihilation
persistent-luminescence
conjugated
polymer
semiconducting
multi-nanoparticle
assemblies,
doped
labeled
including
but
not
limited
those
based
on
polymers
silica.
As
an
exercise
these
ranked
several
application-related
functional
criteria.
Additional
sections
highlight
recent
examples
advances
analysis,
point-of-care
diagnostics,
cellular,
tissue,
vivo
theranostics.
drawn
from
literature
organized
material
particular
properties
that
leveraged
advantage.
Finally,
perspective
what
comes
next
field
offered.
Abstract
Intrinsically
fluorescent
poly(amidoamine)
dendrimers
(IF‐PAMAM)
are
an
emerging
class
of
versatile
nanoplatforms
for
in
vitro
tracking
and
bio‐imaging.
However,
limited
tissue
penetration
their
fluorescence
interference
due
to
auto‐fluorescence
arising
from
biological
tissues
limit
its
application
vivo.
Herein,
a
green
IF‐PAMAM
(FGP)
dendrimer
is
reported
biocompatibility,
circulation,
biodistribution
potential
role
traceable
central
nervous
system
(CNS)‐targeted
delivery
zebrafish
evaluated,
exploring
various
routes
administration.
Key
features
FGP
include
visible
light
excitation
(488
nm),
high
signal
intensity,
superior
photostability
low
auto‐fluorescence.
After
intravenous
injection,
shows
excellent
imaging
performance
zebrafish.
Further
conjugating
with
transferrin
(FGP‐Tf)
significantly
increases
through
the
blood–brain
barrier
(BBB)
prolongs
circulation
blood
stream.
When
administering
local
intratissue
microinjection,
including
intracranial
intrathecal
injection
zebrafish,
both
FGP‐Tf
exhibit
diffusion
effective
cellular
uptake
brain
spinal
cord,
respectively.
This
makes
FGP/FGP‐Tf
attractive
vivo
tracing
when
transporting
CNS
desired.
The
work
addresses
some
major
shortcomings
provides
promising
these
probes
development
drug
CNS.
Chemical Reviews,
Год журнала:
2024,
Номер
124(9), С. 5505 - 5616
Опубликована: Апрель 16, 2024
The
recent
emergence
of
nanomedicine
has
revolutionized
the
therapeutic
landscape
and
necessitated
creation
more
sophisticated
drug
delivery
systems.
Polymeric
nanoparticles
sit
at
forefront
numerous
promising
designs,
due
to
their
unmatched
control
over
physiochemical
properties
such
as
size,
shape,
architecture,
charge,
surface
functionality.
Furthermore,
polymeric
have
ability
navigate
various
biological
barriers
precisely
target
specific
sites
within
body,
encapsulate
a
diverse
range
cargo
efficiently
release
this
in
response
internal
external
stimuli.
However,
despite
these
remarkable
advantages,
presence
wider
clinical
application
is
minimal.
This
review
will
provide
comprehensive
understanding
vehicles.
affecting
be
outlined
first,
followed
by
description
nanoparticle
designs
preparation
methods,
beginning
with
polymers
on
which
they
are
based.
meticulously
explore
current
performance
against
myriad
diseases
including
cancer,
viral
bacterial
infections,
before
finally
evaluating
advantages
crucial
challenges
that
determine
potential
decades
come.
Polymers for Advanced Technologies,
Год журнала:
2021,
Номер
32(4), С. 1455 - 1484
Опубликована: Фев. 3, 2021
Stimuli‐responsive
materials
in
general
and
pH‐responsive
polymers
particular
have
gained
increasing
interest
during
the
last
two
decades.
Their
unique
properties,
which
arise
from
their
ability
to
exhibit
sharp
reversible
changes
response
environmental
pH
conditions,
made
them
suitable
for
various
applications
such
as
drug
delivery
specific
body‐site
targeting,
sensing
actuation,
membrane
functionalization,
separation
techniques,
well
agriculture
food
industry
even
chemical
industries.
In
present
review,
focus
is
on
characteristics
of
terms
origin,
composition,
preparation.
Moreover,
some
important
recent
are
reported
discussed.
