Advanced Materials,
Год журнала:
2024,
Номер
36(33)
Опубликована: Июнь 6, 2024
The
growing
aging
population,
with
its
associated
chronic
diseases,
underscores
the
urgency
for
effective
tissue
regeneration
strategies.
Biomaterials
play
a
pivotal
role
in
realm
of
reconstruction
and
regeneration,
distinct
shift
toward
minimally
invasive
(MI)
treatments.
This
transition,
fueled
by
engineered
biomaterials,
steers
away
from
surgical
procedures
to
embrace
approaches
offering
reduced
trauma,
accelerated
recovery,
cost-effectiveness.
In
MI
repair
cargo
delivery,
various
techniques
are
explored.
While
situ
polymerization
is
prominent,
it
not
without
challenges.
narrative
review
explores
diverse
fabrication
methods,
biofunctionalization
injectable
pre-formed
scaffolds,
focusing
on
their
unique
advantages.
exhibiting
compressibility,
controlled
injection,
maintained
mechanical
integrity,
emerge
as
promising
alternative
solutions
conclusion
this
emphasizes
importance
interdisciplinary
design
facilitated
synergizing
fields
materials
science,
advanced
3D
biomanufacturing,
mechanobiological
studies,
innovative
regeneration.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 15, 2024
Abstract
Nanotechnology
holds
immense
promise
in
revolutionising
healthcare,
offering
unprecedented
opportunities
diagnostics,
drug
delivery,
cancer
therapy,
and
combating
infectious
diseases.
This
review
explores
the
multifaceted
landscape
of
nanotechnology
healthcare
while
addressing
critical
aspects
safety
environmental
risks
associated
with
its
widespread
application.
Beginning
an
introduction
to
integration
we
first
delved
into
categorisation
various
materials
employed,
setting
stage
for
a
comprehensive
understanding
potential.
We
then
proceeded
elucidate
diverse
applications
nanotechnology,
spanning
medical
tissue
engineering,
targeted
gene
development
antimicrobial
agents.
The
discussion
extended
current
situation
surrounding
clinical
translation
commercialisation
these
cutting-edge
technologies,
focusing
on
nanotechnology-based
products
that
have
been
approved
globally
date.
also
discussed
considerations
nanomaterials,
both
terms
human
health
impact.
presented
vivo
nanomaterial
exposure,
relation
transport
mechanisms,
oxidative
stress,
physical
interactions.
Moreover,
highlighted
risks,
acknowledging
potential
implications
ecosystems
biodiversity.
Lastly,
strived
offer
insights
regulatory
governing
across
different
regions
globally.
By
synthesising
perspectives,
underscore
imperative
balancing
innovation
stewardship,
charting
path
forward
responsible
healthcare.
Graphical
abstract
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 7547 - 7566
Опубликована: Июль 1, 2024
Abstract:
Cancer
poses
a
significant
threat
to
human
life
and
health.
Chemotherapy
is
currently
one
of
the
effective
cancer
treatments,
but
many
chemotherapy
drugs
have
cell
toxicity,
low
solubility,
poor
stability,
narrow
therapeutic
window,
unfavorable
pharmacokinetic
properties.
To
solve
above
problems,
target
drug
delivery
tumor
cells,
reduce
side
effects
drugs,
an
anti-tumor
system
based
on
microenvironment
has
become
focus
research
in
recent
years.
The
construction
reduction-sensitive
nanomedicine
disulfide
bonds
attracted
much
attention.
Disulfide
good
reductive
responsiveness
can
effectively
high
glutathione
(GSH)
levels
environment,
enabling
precise
delivery.
further
enhance
targeting
accelerate
release,
are
often
combined
with
pH-responsive
nanocarriers
highly
expressed
ligands
cells
construct
systems.
connect
molecules
polymer
system,
as
well
between
different
carrier
molecules.
This
article
summarized
systems
(DDS)
that
researchers
constructed
years
bond
microenvironment,
cleavage-triggering
conditions,
various
loading
strategies,
design.
In
this
review,
we
also
discuss
controlled
release
mechanisms
these
DDS
clinical
applicability
challenges
faced
translation.
Keywords:
bond,
systems,
GSH/ROS
The
emerging
integrated
power
supplies
for
self-powered
bioelectronic
devices
over
the
past
few
years
are
summarized.
Additionally,
challenges
and
future
perspectives
in
device
design
manufacturing
also
indicated.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Nucleic
acid
therapeutics
represent
a
highly
promising
treatment
approach
in
modern
medicine,
treating
diseases
at
the
genetic
level.
However,
these
face
numerous
challenges
practical
applications,
particularly
regarding
their
stability,
effectiveness,
cellular
uptake
efficiency,
and
limitations
delivering
them
specifically
to
target
tissues.
To
overcome
obstacles,
researchers
have
developed
various
innovative
delivery
systems,
including
viral
vectors,
lipid
nanoparticles,
polymer
inorganic
protein
carriers,
exosomes,
antibody
oligonucleotide
conjugates,
DNA
nanostructure-based
systems.
These
systems
enhance
therapeutic
efficacy
of
nucleic
drugs
by
improving
targeting
specificity,
half-life
vivo.
In
this
review,
we
systematically
discuss
different
types
drugs,
analyze
major
barriers
encountered
delivery,
summarize
current
research
progress
emerging
We
also
highlight
latest
advancements
application
for
diseases,
infectious
cancer,
brain
wound
healing.
This
review
aims
provide
comprehensive
overview
drug
systems'
status
future
directions
integrating
nanotechnology,
biomaterials
science,
gene
editing
technologies,
emphasizing
transformative
potential
precision
medicine.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 22, 2024
Abstract
In
designing
aerosolized
drugs,
the
challenge
lies
in
achieving
optimal
penetration
and
retention.
Existing
delivery
systems
prioritize
larger
particles
for
prolonged
intrapulmonary
retention,
compromising
speed.
Conversely,
smaller
nanoparticles
face
rapid
clearance
limited
RNA
sponges
featuring
multiple
microRNA
binding
sites
exhibit
promising
potential
gene
expression
regulation.
However,
complex
structure
of
frequently
utilized
cyclic
sponge
impedes
cellular
uptake,
restricting
its
application.
This
study
proposes
an
innovative
approach
using
a
compact
tetrahedral
framework
nucleic
acid
to
construct
inhalable
sponge.
Distinguished
by
simplified
structure,
this
ensures
effective
inhibition,
tissue
penetration,
residency
through
prompt
endocytosis.
Validated
acute
lung
inflammation
models,
demonstrates
swift
restoration
local
immune
homeostasis.
design
addresses
critical
need
aerosol
vehicles
that
balance
efficient
sustained
offering
solution
Nano Letters,
Год журнала:
2024,
Номер
24(30), С. 9368 - 9376
Опубликована: Июль 16, 2024
Development
of
mRNA
therapeutics
necessitates
targeted
delivery
technology,
while
the
clinically
advanced
lipid
nanoparticles
face
difficulty
for
extrahepatic
delivery.
Herein,
we
design
highly
branched
poly(β-amino
ester)s
(HPAEs)
efficacious
organ-selective
through
tailoring
their
chemical
compositions
and
topological
structures.
Using
an
"A2+B3+C2"
Michael
addition
platform,
a
combinatorial
library
219
HPAEs
with
varied
backbone
structures,
terminal
groups,
branching
degrees
are
synthesized.
The
structures
provide
enhanced
serum
resistance
significantly
higher
expression
in
vivo.
amine
determine
organ-selectivity
following
systemic
administration:
morpholine
facilitates
liver
targeting,
ethylenediamine
favors
spleen
delivery,
methylpentane
enables
to
liver,
spleen,
lungs
simultaneously.
This
study
represents
comprehensive
exploration
structure–activity
relationship
governing
both
efficiency
by
HPAEs,
suggesting
promising
candidates
treating
various
organ-related
diseases.
