Опубликована: Янв. 1, 2024
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Язык: Английский
Chemical Engineering Journal, Год журнала: 2024, Номер 493, С. 152439 - 152439
Опубликована: Май 23, 2024
Язык: Английский
Процитировано
16
Bioactive Materials, Год журнала: 2024, Номер 43, С. 195 - 224
Опубликована: Сен. 24, 2024
Язык: Английский
Процитировано
10
Macromolecular Rapid Communications, Год журнала: 2024, Номер unknown
Опубликована: Июнь 8, 2024
Abstract Soft actuators are one of the most promising technological advancements with potential solutions to diverse fields’ day‐to‐day challenges. derived from hydrogel materials possess unique features such as flexibility, responsiveness stimuli, and intricate deformations, making them ideal for soft robotics, artificial muscles, biomedical applications. This review provides an overview material composition design techniques actuators, exploring 3D printing, photopolymerization, cross‐linking, microfabrication methods improved actuation. It examines applications in biomedical, bioinspired systems, microfluidics, lab‐on‐a‐chip devices, environmental, energy systems. Finally, it discusses challenges, opportunities, advancements, regulatory aspects related actuators.
Язык: Английский
Процитировано
7
Materials Today Bio, Год журнала: 2024, Номер 29, С. 101284 - 101284
Опубликована: Окт. 2, 2024
Язык: Английский
Процитировано
7
Composites Part B Engineering, Год журнала: 2025, Номер unknown, С. 112387 - 112387
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
Polymer, Год журнала: 2024, Номер 308, С. 127384 - 127384
Опубликована: Июль 10, 2024
Язык: Английский
Процитировано
6
Bioprinting, Год журнала: 2024, Номер 43, С. e00360 - e00360
Опубликована: Сен. 26, 2024
Язык: Английский
Процитировано
5
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Окт. 17, 2024
Intracerebral hemorrhage (ICH) is a severe form of stroke characterized by high incidence and mortality rates. Currently, there significant lack effective treatments aimed at improving clinical outcomes. Our research team has developed three-dimensional (3D) biological scaffold that incorporates Bergenin, allowing for the sustained release compound.
Язык: Английский
Процитировано
3
SPE Polymers, Год журнала: 2025, Номер 6(2)
Опубликована: Апрель 1, 2025
Abstract Polycarbonate (PC) is a valuable engineering polymer with numerous technical characteristics like desirable mechanical properties, high heat resistance, chemical optical clarity, and electrical insulation capabilities. Therefore, it finds extensive use in aerospace, automotive, consumer goods, optics, medical devices, electronics. Materials extrusion additive manufacturing offers several advantages, such as customized geometry, minimal material waste, cost‐effectiveness, ease of modification. Accordingly, PC has recently emerged robust durable material. This review aims to investigate how printing parameters materials affect the properties PC‐based materials, specific emphasis on properties. The main drawbacks associated pure filaments, print temperatures, warping tendencies, propensity retract during printing, are also discussed. Considering significant demand for developing blends composites tailored application material‐extrusion manufacturing, influence different types fillers, including polymeric, metallic, ceramic, improving behavior then reviewed. paper explores diverse applications additively manufactured parts, especially within advanced areas engineering, medicine. Lastly, prospects challenges presented review. Highlights key 3D printing. Printing quality strength polycarbonate parts. Various fillers adjust polycarbonate‐based composites' High warping, retraction major challenges. 3D‐printed can be used variety applications.
Язык: Английский
Процитировано
0
Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)
Опубликована: Апрель 20, 2025
Exosome-based therapeutics have garnered significant attention for intracerebral hemorrhage (ICH) treatment due to their capacity regulate metabolic dysregulation, restore cellular homeostasis, and modulate the injury microenvironment via bioactive cargoes such as microRNAs proteins. However, rapid systemic clearance enzymatic degradation critically limit therapeutic efficacy. To address this challenge, we engineered a three-dimensional (3D) bioprinted scaffold capable of encapsulating sustaining release human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-exos). Based on previous research [1-3], was composed decellularized brain matrix (dECM), gelatin-methacryloyl (GelMA), silk fibroin (SF) crosslinked with photoinitiator. hUCMSC-exos were precisely incorporated extrusion-based 3D bioprinting. Release kinetics assessed in vitro elution vivo imaging. An ICH rat model received stereotaxic implantation exosome-laden (dECM@exo). Neuroinflammatory markers (IL-6, TNF-α, IL-10) apoptotic activity (JC-1, Annexin V/PI, TUNEL) quantified. Neurological outcomes longitudinally evaluated using modified Longa scale, Bederson scoring, sensorimotor tests (rotarod, forelimb placement) at 1, 4, 7 14 days post-ICH. dECM@exo demonstrated sustained exosome over days, significantly promoting neural tissue regeneration while attenuating perihematomal edema. Mechanistically, modulated pathological MMP inflammatory cytokine expression, thereby restoring extracellular homeostasis reducing neuronal apoptosis. The findings demonstrate that biological effectively maintains microenvironmental early stages improves associated condition. is poised serve robust platform drug delivery biotherapy treatment, offering viable alternative managing
Язык: Английский
Процитировано
0