Hypomethylation‐associated ELF3 helps nasopharyngeal carcinoma to escape immune surveillance via MUC16-mediated glycolytic metabolic reprogramming DOI
Yueyang Liu, Hong Zhou, Yu Qi

и другие.

AJP Cell Physiology, Год журнала: 2024, Номер 327(4), С. C1125 - C1142

Опубликована: Сен. 2, 2024

Immune escape and metabolic reprogramming are two essential hallmarks of cancer. Mucin-16 (MUC16) has been linked to glycolysis immune response in different cancers. However, its involvement nasopharyngeal carcinoma (NPC) not well described. We seek dissect the functions detailed mechanisms MUC16 NPC. Bioinformatics prediction was performed identify NPC-related molecules. significantly enhanced NPC tissues, which correlated with advanced tumor stage patients. Lentiviral plasmids-mediated deletion inhibited malignant behavior cells, inhibition by blocked cells. E74-like factor 3 (ELF3) bound promoter promotes transcription MUC16. overexpression reversed repressive effect ELF3 silencing on accelerated growth vivo. Overexpression associated reduced DNA methylation promoter. Our findings revealed role ELF3/MUC16 axis NPC, providing potential therapeutic targets for

Язык: Английский

The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma DOI Creative Commons

Qiaonan Shan,

Lu Yin,

Qifan Zhan

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 19, 2024

Язык: Английский

Процитировано

10
ENPP1 Promotes Immune Suppression, Drug Resistance, and Adverse Outcomes in Bladder Cancer: Potential for Targeted Therapy DOI
Chengyu You,

Qixiang Fang,

Xi Xiao

и другие.

Cancer Genetics, Год журнала: 2025, Номер 294-295, С. 1 - 14

Опубликована: Март 4, 2025

Язык: Английский

Процитировано

0
Hypomethylation‐associated ELF3 helps nasopharyngeal carcinoma to escape immune surveillance via MUC16-mediated glycolytic metabolic reprogramming DOI
Yueyang Liu, Hong Zhou, Yu Qi

и другие.

AJP Cell Physiology, Год журнала: 2024, Номер 327(4), С. C1125 - C1142

Опубликована: Сен. 2, 2024

Immune escape and metabolic reprogramming are two essential hallmarks of cancer. Mucin-16 (MUC16) has been linked to glycolysis immune response in different cancers. However, its involvement nasopharyngeal carcinoma (NPC) not well described. We seek dissect the functions detailed mechanisms MUC16 NPC. Bioinformatics prediction was performed identify NPC-related molecules. significantly enhanced NPC tissues, which correlated with advanced tumor stage patients. Lentiviral plasmids-mediated deletion inhibited malignant behavior cells, inhibition by blocked cells. E74-like factor 3 (ELF3) bound promoter promotes transcription MUC16. overexpression reversed repressive effect ELF3 silencing on accelerated growth vivo. Overexpression associated reduced DNA methylation promoter. Our findings revealed role ELF3/MUC16 axis NPC, providing potential therapeutic targets for

Язык: Английский

Процитировано

0