AJP Cell Physiology, Год журнала: 2024, Номер 327(4), С. C1125 - C1142
Опубликована: Сен. 2, 2024
Immune escape and metabolic reprogramming are two essential hallmarks of cancer. Mucin-16 (MUC16) has been linked to glycolysis immune response in different cancers. However, its involvement nasopharyngeal carcinoma (NPC) not well described. We seek dissect the functions detailed mechanisms MUC16 NPC. Bioinformatics prediction was performed identify NPC-related molecules. significantly enhanced NPC tissues, which correlated with advanced tumor stage patients. Lentiviral plasmids-mediated deletion inhibited malignant behavior cells, inhibition by blocked cells. E74-like factor 3 (ELF3) bound promoter promotes transcription MUC16. overexpression reversed repressive effect ELF3 silencing on accelerated growth vivo. Overexpression associated reduced DNA methylation promoter. Our findings revealed role ELF3/MUC16 axis NPC, providing potential therapeutic targets for
Язык: Английский