The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma
Qiaonan Shan,
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Lu Yin,
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Qifan Zhan
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et al.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Sept. 19, 2024
Language: Английский
ENPP1 Promotes Immune Suppression, Drug Resistance, and Adverse Outcomes in Bladder Cancer: Potential for Targeted Therapy
Chengyu You,
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Qixiang Fang,
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Xi Xiao
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et al.
Cancer Genetics,
Journal Year:
2025,
Volume and Issue:
294-295, P. 1 - 14
Published: March 4, 2025
Language: Английский
Hypomethylation‐associated ELF3 helps nasopharyngeal carcinoma to escape immune surveillance via MUC16-mediated glycolytic metabolic reprogramming
Yueyang Liu,
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Hong Zhou,
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Yu Qi
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et al.
AJP Cell Physiology,
Journal Year:
2024,
Volume and Issue:
327(4), P. C1125 - C1142
Published: Sept. 2, 2024
Immune
escape
and
metabolic
reprogramming
are
two
essential
hallmarks
of
cancer.
Mucin-16
(MUC16)
has
been
linked
to
glycolysis
immune
response
in
different
cancers.
However,
its
involvement
nasopharyngeal
carcinoma
(NPC)
not
well
described.
We
seek
dissect
the
functions
detailed
mechanisms
MUC16
NPC.
Bioinformatics
prediction
was
performed
identify
NPC-related
molecules.
significantly
enhanced
NPC
tissues,
which
correlated
with
advanced
tumor
stage
patients.
Lentiviral
plasmids-mediated
deletion
inhibited
malignant
behavior
cells,
inhibition
by
blocked
cells.
E74-like
factor
3
(ELF3)
bound
promoter
promotes
transcription
MUC16.
overexpression
reversed
repressive
effect
ELF3
silencing
on
accelerated
growth
vivo.
Overexpression
associated
reduced
DNA
methylation
promoter.
Our
findings
revealed
role
ELF3/MUC16
axis
NPC,
providing
potential
therapeutic
targets
for
Language: Английский