COVID-19 severity is associated with population-level gut microbiome variations

Frontiers in Cellular and Infection Microbiology, Год журнала: 2022, Номер 12

Опубликована: Авг. 23, 2022

The human gut microbiome interacts with many diseases, recent small studies suggesting a link COVID-19 severity. Exploring this association at the population-level may provide novel insights and help to explain differences in severity between countries. We explore whether there is an of people within different countries COVID-19, measured as hospitalisation rate. use data from large (n = 3,055) open-access repository curatedMetagenomicData, well demographic country-level metadata. Twelve were placed into two groups (high/low) according rate before December 2020 (ourworldindata.com). unsupervised machine learning method, Topological Data Analysis (TDA). This method analyses both local geometry global topology high-dimensional dataset, making it particularly suitable for data. report distinct baseline signatures was found PERMANOVA, TDA. Specifically, suggests anti-inflammatory bacteria, including Bifidobacteria species Eubacterium rectale , lower severity, pro-inflammatory bacteria such Prevotella copri higher study also reports significant impact confounders, specifically proportion over 70-year-olds population, GDP, development index. Further interventional should examine these relationships are causal, considering contribution other variables genetics, lifestyle, policy, healthcare system. results support value design research general microbiome-COVID-19 relationship, particular. Finally, underscores potential TDA studies, identifying associations.

Язык: Английский

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Potential Prion Involvement in Long COVID-19 Neuropathology, Including Behavior

Cellular and Molecular Neurobiology, Год журнала: 2023, Номер 43(6), С. 2621 - 2626

Опубликована: Март 28, 2023

Abstract Prion’ is a term used to describe protein infectious particle responsible for several neurodegenerative diseases in mammals, e.g., Creutzfeldt-Jakob disease. The novelty that it based agent not involving nucleic acid genome as found viruses and bacteria. Prion disorders exhibit, part, incubation periods, neuronal loss, induce abnormal folding of specific normal cellular proteins due enhancing reactive oxygen species associated with mitochondria energy metabolism. These agents may also memory, personality movement abnormalities well depression, confusion disorientation. Interestingly, some these behavioral changes occur COVID-19 mechanistically include mitochondrial damage caused by SARS-CoV-2 subsequenct production species. Taken together, we surmise, long COVID involve the induction spontaneous prion emergence, especially individuals susceptible its origin thus explain manesfestions post-acute viral infection.

Язык: Английский

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Profiles of gut microbiota associated with clinical outcomes in patients with different stages of SARS-CoV-2 infection

Life Sciences, Год журнала: 2023, Номер 332, С. 122136 - 122136

Опубликована: Окт. 1, 2023

Язык: Английский

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A systematic review of gut microbiota profile in COVID‐19 patients and among those who have recovered from COVID‐19

Journal of Digestive Diseases, Год журнала: 2023, Номер 24(4), С. 244 - 261

Опубликована: Апрель 1, 2023

Objectives Given the scale and persistence of coronavirus disease 2019 (COVID‐19), significant attention has been devoted to understanding relationship between human gut microbiota COVID‐19. In this systematic review we aimed comprehensively assess composition in patients infected with COVID‐19 those recovered from comparison healthy controls (HCs). Methods Peer‐reviewed articles preprints published up September 1, 2022, were searched Ovid MEDLINE, EMBASE, SCOPUS. Observational studies reporting profile adult (≥18 years) or compared HCs eligible for inclusion review. The quality assessment was performed using Newcastle‐Ottawa scale. Results We identified 27 comprising 18 that six HCs, while other three both HCs. Compared decreased microbial diversity richness a distinctive reported patients. patients, Bacteroidetes found be enriched, Firmicutes depleted. Decreased short‐chain fatty acid (SCFA)‐producing bacteria, such as Faecalibacterium , Ruminococcus Bifidobacterium among others, also observed which not restored normal levels who recovered. Conclusion Gut dysbiosis evident COVID‐19, available data suggested persisted even SCFA‐producing bacteria.

Язык: Английский

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Alterations in the gut microbiome and its metabolites are associated with the immune response to mucosal immunization with Lactiplantibacillus plantarum-displaying recombinant SARS-CoV-2 spike epitopes in mice

Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13

Опубликована: Авг. 29, 2023

Lactic acid bacteria (LAB) expressing foreign antigens have great potential as mucosal vaccines. Our previous study reported that recombinant Lactiplantibacillus plantarum SK156 displaying SARS-CoV-2 spike S1 epitopes elicited humoral and cell-mediated immune responses in mice. Here, we further examined the effect of LAB-based vaccine on gut microbiome composition function, microbiota-derived metabolites. Forty-nine (49) female BALB/c mice were orally administered L. SK156-displaying thrice (at 14-day intervals). Mucosal immunization considerably altered by enriching abundance beneficial bacteria, such Muribaculaceae, Mucispirillum, Ruminococcaceae, Alistipes, Roseburia, Clostridia vadinBB60. Moreover, predicted function showed increased metabolic pathways for amino acids, energy, carbohydrates, cofactors, vitamins. The fecal concentration short-chain fatty especially butyrate, was also immunization. Notably, alterations composition, butyrate levels positively associated with response to vaccine. results suggest its metabolites may influenced immunogenicity

Язык: Английский

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Untangling the link between the human gut microbiota composition and the severity of the symptoms of the COVID‐19 infection

Environmental Microbiology, Год журнала: 2022, Номер 24(12), С. 6453 - 6462

Опубликована: Сен. 10, 2022

Abstract Recent pandemic infection caused by SARS‐CoV‐2 (COVID‐19) led the scientific community to investigate possible causes contributing physiopathology of this disease. In context, analyses intestinal microbiota highlighted correlation between host‐associated bacterial communities and development COVID‐19. Nevertheless, a detailed investigation role human in severity symptoms disease is still lacking. This study performed comprehensive meta‐analysis 323 faecal samples from public novel Italian data sets based on shotgun metagenomic approach. detail, comparative revealed differences microbial biodiversity related individual health status, highlighting species richness decrease COVID‐19 patients with severe prognosis. Moreover, healthy subjects resulted characterized higher abundance protective health‐supporting species, while affected displayed significant increase opportunistic pathogen bacteria involved developing putrefactive dysbiosis. Furthermore, prediction microbiome functional capabilities suggested that individuals subsist an unbalanced metabolism overrepresentation enzymes protein at expense carbohydrates oriented pathways, which can impact excessive systemic inflammation.

Язык: Английский

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Dysrupted microbial tryptophan metabolism associates with SARS-CoV-2 acute inflammatory responses and long COVID

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Ноя. 17, 2024

Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and risk of long COVID has been associated with the depletion or over-abundance specific taxa within gut microbiome. However, microbial mechanisms mediating these effects are not yet known. We hypothesized that altered production tryptophan its downstream derivatives might contribute to inappropriate immune responses viral infection. In patients hospitalized COVID-19 (

Язык: Английский

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SARS-CoV-2 infection threatening intestinal health: A review of potential mechanisms and treatment strategies

Critical Reviews in Food Science and Nutrition, Год журнала: 2022, Номер 63(33), С. 12578 - 12596

Опубликована: Июль 27, 2022

The outbreak of the COVID-19 pandemic has brought great problems to mankind, including economic recession and poor health. patients are frequently reported with gastrointestinal symptoms such as diarrhea vomiting in clinical diagnosis. Maintaining intestinal health is key guarantee maintain normal function multiple organs, otherwise it will be a disaster. Therefore, purpose this review was deeply understanded potential mechanism SARS-CoV-2 infection threatening put forward reasonable treatment strategies. Combined existing researches, we summarized health, microbiome disruption, barrier dysfunction, oxidative stress cytokine storm. These adverse events may affect other organs through circulatory system or aggravate course disease. Typically, disadvantage promote progression gut-lung axis increase disease degree patients. In view lack specific drugs inhibit replication, current described new strategies probiotics, prebiotics, postbiotics nutrients combat To provide insights for prevention pneumonia COVID-19.

Язык: Английский

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Disentangling the interactions between nasopharyngeal and gut microbiome and their involvement in the modulation of COVID-19 infection

Microbiology Spectrum, Год журнала: 2023, Номер 11(5)

Опубликована: Сен. 20, 2023

The human organism is inhabited by trillions of microorganisms, known as microbiota, which are considered to exploit a pivotal role in the regulation host health and immunity. Recent investigations have suggested relationship between composition microbiota COVID-19 infection, highlighting possible bacterial communities modulation disease severity. In this study, we performed shotgun metagenomics analysis explore compare nasopharyngeal 38 hospitalized Italian patients with without infection during third fourth pandemic waves. detail, metagenomic combined specific correlation analyses positive association several microbial species, such S. parasanguinis P. melaninogenica, severity infection. Furthermore, comparison their respective fecal samples highlighted an these different compartments represented sharing species. Additionally, lipidomic deep-shotgun functional metabolic impact microbiome on host's immune response, indicating presence key compounds patients, lipid oxidation end products, potentially related inflammatory state. Conversely, displayed enzymatic patterns associated biosynthesis degradation like lysine (synthesis) phenylalanine (degradation) that could positively contribute modulating IMPORTANCE reported play major immunity, suggesting disease. This preliminary study investigated species bacteria samples. Moreover, response

Язык: Английский

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Hair Growth Promoting Effects of Solubilized Sturgeon Oil and Its Correlation with the Gut Microbiome

Pharmaceuticals, Год журнала: 2024, Номер 17(9), С. 1112 - 1112

Опубликована: Авг. 23, 2024

Androgenetic alopecia is a common disease that occurs in both men and women. Several approved medications have been used to treat this condition, but they are associated with certain side effects. Therefore, use of extracts derived from natural products, such as Siberian sturgeon (Acipenser baerii), the regulation gut microbiota become important topics research. Sturgeon known for its high nutritional value anti-inflammatory properties; however, effects on androgenetic remain uncharacterized. Here, we aimed investigate whether solubilized oil (SSO) promotes hair growth regulates microbiome. C57BL/6 mice were divided into four groups. Three groups received topical applications distilled water, SSO, or minoxidil, one group was orally administered SSO. Each treatment over 4 weeks. Histopathological analysis revealed significant increase follicle number (p < 0.001) diameter 0.05). Immunohistochemical upregulation β-catenin ERK-1, markers involved growth-promoting pathways. Furthermore, microbiome reduced negatively correlated these markers. Our findings indicate oral administration SSO abundance microbiota.

Язык: Английский

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