“Find Me” and “Eat Me” signals: tools to drive phagocytic processes for modulating antitumor immunity
Cancer Communications,
Год журнала:
2024,
Номер
44(7), С. 791 - 832
Опубликована: Июнь 23, 2024
Phagocytosis,
a
vital
defense
mechanism,
involves
the
recognition
and
elimination
of
foreign
substances
by
cells.
Phagocytes,
such
as
neutrophils
macrophages,
rapidly
respond
to
invaders;
macrophages
are
especially
important
in
later
stages
immune
response.
They
detect
"find
me"
signals
locate
apoptotic
cells
migrate
toward
them.
Apoptotic
then
send
"eat
that
recognized
phagocytes
via
specific
receptors.
"Find
can
be
strategically
harnessed
modulate
antitumor
immunity
support
cancer
therapy.
These
signals,
calreticulin
phosphatidylserine,
mediate
potent
pro-phagocytic
effects,
thereby
promoting
engulfment
dying
or
their
remnants
neutrophils,
dendritic
inducing
tumor
cell
death.
This
review
summarizes
phagocytic
including
concepts,
signaling
mechanisms,
involved
ligands,
functions.
Furthermore,
we
delineate
relationships
between
molecules
tumors,
roles
these
initiation,
progression,
diagnosis,
patient
prognosis.
The
interplay
with
biology
is
elucidated,
approaches
enhance
explored.
Additionally,
novel
therapeutic
strategies
combine
better
bridge
innate
adaptive
treatment
patients
discussed.
Язык: Английский
A pH and glutathione-responsive carbon monoxide-driven nano-herb delivery system for enhanced immunotherapy in colorectal cancer
Journal of Controlled Release,
Год журнала:
2024,
Номер
376, С. 659 - 677
Опубликована: Окт. 28, 2024
Язык: Английский
Low hydrostatic pressure promotes functional homeostasis of nucleus pulposus cells through the TRPV4/CRT/FA complex axis
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 29, 2025
The
low
hydrostatic
pressure
in
the
intervertebral
disc
plays
a
crucial
role
maintaining
homeostasis
of
environment,
particularly
supporting
physiological
functions
nucleus
pulposus
cells
(NPCs).
However,
underlying
mechanisms
remain
poorly
understood.
TRPV4,
baroreceptor
disc,
is
primarily
responsible
for
converting
extracellular
signals
into
intracellular
chemical
signals.
Upon
activation,
TRPV4
facilitates
influx
calcium
ions,
thereby
regulating
behavior
NP
cells.
Calreticulin
(CRT),
an
endoplasmic
reticulum
retention
protein,
performs
various
functions,
including
regulation
levels.
CRT
also
exhibits
distinct
roles
depending
on
its
subcellular
localization.
In
this
study,
we
observed
that
under
pressure,
activation
and
subsequent
led
to
increase
synthesis
significant
rise
cytosolic
expression.
This
was
followed
by
depolymerization
focal
adhesion
(FA)
complexes,
consisting
FAK
integrin
β1,
which
resulted
collagen
type
II
(Col
II)
decrease
I
I).
These
changes
matrix
(ECM)
composition
helped
maintain
function
Furthermore,
overexpression
enhanced
ability
resist
partial
functional
damage
caused
high
pressure.
Taken
together,
our
findings
suggested
cell
TRPV4/CRT/FA
complex
signaling
axis.
Язык: Английский
Alleviation effect of macrophage depletion on hepatotoxicity of triptolide: A new insight based on metabolomics and proteomics
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 119485 - 119485
Опубликована: Фев. 1, 2025
Язык: Английский
From death to birth: how osteocyte death promotes osteoclast formation
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 17, 2025
Bone
remodeling
is
a
dynamic
and
continuous
process
involving
three
components:
bone
formation
mediated
by
osteoblasts,
resorption
osteoclasts,
formation-resorption
balancing
regulated
osteocytes.
Excessive
osteocyte
death
found
in
various
diseases,
such
as
postmenopausal
osteoporosis
(PMOP),
osteoclasts
are
increased
activated
at
sites.
Currently,
apart
from
apoptosis
necrosis
previously
established,
more
forms
of
cell
reported,
including
necroptosis,
ferroptosis
pyroptosis.
These
play
important
role
the
development
inflammatory
diseases
diseases.
Increasing
studies
have
revealed
that
promote
osteoclast
via
different
mechanism,
actively
secreting
pro-inflammatory
pro-osteoclastogenic
cytokines,
tumor
factor
alpha
(TNF-α)
receptor
activator
nuclear
factor-kappa
B
ligand
(RANKL),
or
passively
releasing
damage
associated
molecule
patterns
(DAMPs),
high
mobility
group
box
1
(HMGB1).
This
review
summarizes
established
potential
mechanisms
which
regulate
formation,
aiming
to
provide
better
understanding
disease
therapeutic
target.
Язык: Английский
Role of Cell Deaths in Human Disabilities
Опубликована: Янв. 1, 2025
Язык: Английский
Evoking the Cancer-immunity cycle by targeting the tumor-specific antigens in Cancer immunotherapy
International Immunopharmacology,
Год журнала:
2025,
Номер
154, С. 114576 - 114576
Опубликована: Апрель 2, 2025
Язык: Английский
PEGylated Elesclomol@Cu(Ⅱ)-based Metal‒organic Framework with Effective Nanozyme Performance and Cuproptosis Induction Efficacy for Enhanced PD-L1-based Immunotherapy
Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101317 - 101317
Опубликована: Окт. 30, 2024
Язык: Английский