Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 13, 2024
Pyroptosis
is
a
form
of
inflammatory
programmed
cell
death,
and
activated
by
pathogen
infections
or
endogenous
danger
signals.
The
canonical
pyroptosis
process
characterized
the
inflammasome
(typically
NLRP3)-mediated
activation
caspase-1,
which
in
turn
cleaves
activates
IL-1β
IL-18,
as
well
gasdermin
D,
pore-forming
executor
protein,
leading
to
membrane
rupture,
release
proinflammatory
cytokines
damage-associated
molecular
pattern
molecules.
considered
part
innate
immune
response.
A
certain
level
can
help
eliminate
pathogenic
microorganisms,
but
excessive
lead
persistent
responses,
cause
tissue
damage.
In
recent
years,
has
emerged
crucial
contributor
development
chronic
respiratory
diseases,
such
asthma.
present
study
reviews
involvement
asthma,
terms
its
role
different
phenotypes
disease,
influence
on
various
non-immune
cells
airway.
addition,
potential
therapeutic
value
targeting
for
treatment
specific
asthma
discussed.
Cardiology in Review,
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 18, 2023
Asthma
and
cardiovascular
diseases
(CVDs)
are
the
2
common
complex
health
problems
with
a
substantial
global
impact.
Epidemiological
studies
indicate
that
asthma
CVDs
common,
evidence
supporting
their
cooccurrence.
Inflammation,
oxidative
stress,
obesity,
metabolic
syndrome,
smoking,
secondhand
smoke
exposure,
physical
inactivity,
environmental
exposures
all
risk
factors
for
CVDs.
In
addition,
inflammatory
immunological
pathways,
autonomic
dysfunction,
endothelial
thrombosis,
coagulation,
genetic
contribute
to
asthma-CVD
relationship.
Asthmatic
individuals
have
higher
morbidity
mortality
rates
related
high-risk
factors.
Techniques
such
as
screening
in
patients,
pharmaceutical
therapy,
lifestyle
changes
critical
effectively
managing
these
comorbid
illnesses.
Understanding
link
between
CVD
is
necessary
integrated
clinical
management
approaches
enhance
patient
outcomes
lessen
burden
of
diseases.
Biomolecules and Biomedicine,
Год журнала:
2024,
Номер
24(4), С. 708 - 721
Опубликована: Янв. 8, 2024
The
inflammatory
response
is
a
natural
immune
that
prevents
microbial
invasion
and
repairs
damaged
tissues.
However,
excessive
responses
can
lead
to
various
inflammation-related
diseases,
posing
significant
threat
human
health.
NOD-like
receptor
pyrin
domain-containing
protein
3
(NLRP3)
inflammasome
vital
mediator
in
the
activation
of
cascade.
Targeting
hyperactivation
NLRP3
may
offer
potential
strategies
for
prevention
or
treatment
diseases.
It
has
been
established
ubiquitination
deubiquitination
modifications
provide
protective
effects
These
modulate
several
pathological
processes,
including
responses,
pyroptosis,
abnormal
autophagy,
proliferation
disorders,
oxidative
stress
damage.
Therefore,
this
review
discusses
regulation
by
modifications,
explores
role
these
examines
underlying
mechanisms.
Brain Sciences,
Год журнала:
2024,
Номер
14(5), С. 467 - 467
Опубликована: Май 7, 2024
B355252
is
a
small
molecular
compound
known
for
potentiating
neural
growth
factor
and
protecting
against
neuronal
cell
death
induced
by
glutamate
in
vitro
cerebral
ischemia
vivo.
However,
its
other
biological
functions
remain
unclear.
This
study
aims
to
investigate
whether
suppresses
neuroinflammatory
responses
the
brain.
C57BL/6j
mice
were
intraperitoneally
injected
with
single
dosage
of
lipopolysaccharide
(LPS,
1
mg/kg)
induce
inflammation.
(1
intervention
was
started
two
days
prior
LPS
injection.
The
animal
behavioral
changes
assessed
pre-
post-LPS
injections.
brains
harvested
at
4
24
h
injection,
histological,
biochemical,
cytokine
array
outcomes
examined.
Results
showed
that
improved
LPS-induced
deterioration,
mitigated
brain
tissue
damage,
suppressed
activation
microglial
astrocytes.
Furthermore,
reduced
protein
levels
key
pyroptotic
markers
TLR4,
NLRP3,
caspase-1
inhibited
increases
IL-1β,
IL-18,
cytokines.
In
conclusion,
demonstrates
potent
anti-neuroinflammatory
effect
vivo,
suggesting
potential
therapeutic
value
warrants
further
investigation.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 5545 - 5579
Опубликована: Июнь 1, 2024
Pyroptosis,
a
pro-inflammatory
and
lytic
programmed
cell
death
pathway,
possesses
great
potential
for
antitumor
immunotherapy.
By
releasing
cellular
contents
large
number
of
factors,
tumor
pyroptosis
can
promote
dendritic
maturation,
increase
the
intratumoral
infiltration
cytotoxic
T
cells
natural
killer
cells,
reduce
immunosuppressive
within
tumor.
However,
efficient
induction
prevention
damage
to
normal
tissues
or
is
an
urgent
concern
be
addressed.
Recently,
wide
variety
nanoplatforms
have
been
designed
precisely
trigger
activate
immune
responses.
This
review
provides
update
on
progress
in
nanotechnology
enhancing
pyroptosis-based
Nanomaterials
shown
advantages
triggering
by
delivering
initiators
tumors,
increasing
oxidative
stress
inducing
intracellular
osmotic
pressure
changes
ion
imbalances.
In
addition,
challenges
future
perspectives
this
field
are
proposed
advance
clinical
translation
pyroptosis-inducing
nanomedicines.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
179, С. 117367 - 117367
Опубликована: Авг. 29, 2024
The
pyroptosis
of
cardiomyocytes
has
become
an
essential
topic
in
heart
failure
research.
abnormal
accumulation
these
biological
factors,
including
angiotensin
II,
advanced
glycation
end
products,
and
various
growth
factors
(such
as
connective
tissue
factor,
vascular
endothelial
transforming
factor
beta,
among
others),
activates
the
nuclear
factor-κB
(NF-κB)
signaling
pathway
cardiovascular
diseases,
ultimately
leading
to
cardiomyocytes.
Therefore,
exploring
underlying
molecular
mechanisms
is
for
developing
novel
drugs
therapeutic
strategies.
However,
our
current
understanding
precise
regulatory
mechanism
this
complex
cardiomyocyte
still
limited.
Given
this,
study
reviews
milestone
discoveries
field
research
since
1986,
analyzes
detail
similarities,
differences,
interactions
between
other
cell
death
modes
apoptosis,
necroptosis,
autophagy,
ferroptosis),
explores
deep
connection
failure.
At
same
time,
it
depicts
complete
activation,
transmission,
eventual
NF-κB
process
In
addition,
also
systematically
summarizes
approaches
that
can
inhibit
reduce
pyroptosis,
drugs,
natural
compounds,
small
molecule
inhibitors,
gene
editing,
cutting-edge
technologies,
aiming
provide
solid
scientific
support
new
perspectives
prevention
treatment
