Life Sciences, Год журнала: 2024, Номер 358, С. 123199 - 123199
Опубликована: Ноя. 1, 2024
Язык: Английский
OpenNano, Год журнала: 2023, Номер 15, С. 100199 - 100199
Опубликована: Дек. 25, 2023
On a global scale, lung cancer remains common malignancy and is largest cause of many deaths related to cancer. Despite the significant advancements in diagnostic therapeutic approaches, individuals exhibit resistant responses proven therapies. This focuses on critical need for novel methods be developed innovated. Recently, nanotechnology has gained lot importance treating as it helps improve drug delivery, specificity, reduced dose, efficient elimination. Lipid nanoparticles (LNPs) are nanocarriers with low particle size, which can modified specific delivery. The current review significance application lipid-based theranostic therapy, components, method preparation factors affecting lipid nanoparticle preparation, along clinical trials patents LNPs. Therapeutic applications therapy include Chemotherapy, photodynamic immunotherapy, gene photothermal sonodynamic therapy. Diagnostic like SPECT, CT, MRI, PET, Optical fluorescence imaging NIR. As LNPs being used more frequently ongoing research offering solutions overcome issues by conventional treatments. Due their adaptability customized medical procedures use numerous they hold potential In conclusion, offer viable strategy boosting bioavailability, promoting medication removing obstacles. For individualised medicine, encapsulate range therapeutic, such immunomodulatory medicines, siRNA, chemotherapeutic medications. Additional study validation required address scalability, long-term safety, optimised manufacturing techniques effective
Язык: Английский
Процитировано
13
Journal of Photochemistry and Photobiology C Photochemistry Reviews, Год журнала: 2024, Номер 59, С. 100665 - 100665
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
5
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10388 - 10388
Опубликована: Сен. 26, 2024
Bladder cancer (BC) is one of the most common malignant neoplasms genitourinary system. Traditional BC therapies include chemotherapy, targeted therapy, and immunotherapy. However, limitations such as lack specificity, cytotoxicity, multidrug resistance pose serious challenges to benefits therapies. Consequently, current studies focus on search for new therapeutic solutions. In recent years, there has been a growing interest in using nanotechnology treatment both non-invasive (NMIBC) invasive bladder (MIBC). Nanotechnology based use organic molecules (chitosan, liposomes) inorganic (superparamagnetic iron oxide nanoparticles) carriers active substances. The main aim transport prolonged retention drug target tissue, which increases efficacy substance. This review discusses numerous types nanoparticles (including chitosan, polymeric nanoparticles, liposomes, protein nanoparticles), targeting mechanisms, approved nanotherapeutics with oncological implications treatment. We also present nanoformulation applications phototherapy, gene Moreover, we summarise perspectives, advantages, clinical translation.
Язык: Английский
Процитировано
4
International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 181 - 197
Опубликована: Янв. 1, 2025
Abstract: The microenvironment tends to be immunosuppressive during tumor growth and proliferation. Immunotherapy has attracted much attention because of its ability activate tumor-specific immune responses for killing. cyclic GMP-AMP synthase-stimulator interferon genes (cGAS-STING) pathway is an innate that activates antitumor immunity by producing type I interferons. Cyclic dinucleotides (CDNs), produced cGAS sensing cytoplasmic abnormal DNA, are major intermediate activating molecules in the STING pathway. Nowadays, CDNs their derivatives have widely worked as powerful agonists immunotherapy. However, clinical translation hindered negative electrical properties, sensitivity hydrolytic enzymes, systemic toxicity. Recently, various CDN delivery systems made significant progress addressing these issues, either through monotherapy or combination with other treatment modalities. This review details recent advances CDNs-based pharmaceutical development strategies enriching at sites Keywords: dinucleotides, stimulator pathway, immunotherapy
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2025, Номер 148, С. 114013 - 114013
Опубликована: Янв. 18, 2025
Язык: Английский
Процитировано
0
Advances in immunology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106891 - 106891
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Апрель 15, 2025
Cancer immunotherapy aims to harness the body's own immune system for effective and long-lasting elimination of malignant neoplastic tissues. Owing advance in understanding cancer pathology immunology, many novel strategies enhancing immunological responses against various cancers have been successfully developed, some translated into excellent clinical outcomes. As one promising strategy next generation immunotherapies, activating multi-cellular network (MCN) within tumor microenvironment (TME) deploy multiple mechanisms action (MOAs) has attracted significant attention. To achieve this effectively safely, delivering or pleiotropic therapeutic cargoes targeted sites cancerous tissues, cells, intracellular organelles is critical, which numerous nanocarriers developed leveraged. In review, we first introduce payloads categorized according their predicted functions physicochemical structures forms. Then, nanocarriers, along with unique characteristics, properties, advantages, limitations, are introduced notable recent applications immunotherapy. Following discussions on targeting strategies, a summary each nanocarrier matching suitable provided comprehensive background information designing regimens.
Язык: Английский
Процитировано
0
Aquaculture International, Год журнала: 2025, Номер 33(4)
Опубликована: Апрель 23, 2025
Язык: Английский
Процитировано
0
Опубликована: Апрель 22, 2024
Since their inception in the early 1960s, use of nanoscale materials has progressed leaps and bounds, role diverse fields ranging from human health to energy is undeniable. In this report, we utilize CAS Content Collection, a vast repository scientific information extracted journal patent publications, identify emerging topics field. This involves understanding trends, such as growth certain over time, well establishing relationships between topics. We achieved by using host strategies including quantitative natural language processing (NLP) approach 279 sub-topics across three major categories – materials, applications, properties surveying roughly 3 million publications nanoscience landscape. wealth been condensed into several conceptual mind maps other graphs that provide metrics related identified concepts, group them hierarchical classes, explore connections them. delved deeper four applications drug delivery, sensors, energy, catalysis more comprehensive detailed picture nanotechnology these fields. addition, leveraged registry, consisting 250 substances, determine discover substances varied classes (such polymers, elements, organic/inorganic molecules) how they are utilized 4 applications. Our extensive analysis taking advantage an NLP-based along with robust indexing provides valuable insights field hope can help inform drive future research efforts.
Язык: Английский
Процитировано
3