Probiotics, prebiotics, and postbiotics in health and disease

MedComm, Год журнала: 2023, Номер 4(6)

Опубликована: Ноя. 4, 2023

The gut microbiota and its homeostasis play a crucial role in human health. However, for some diseases related to the microbiota, current traditional medicines can only relieve symptoms, it is difficult solve root causes or even cause side effects like disturbances microbiota. Increasing clinical studies evidences have demonstrated that probiotics, prebiotics, postbiotics prevent treat various diseases, but currently they be used as dietary supplements rather than medicines, which restricts application of probiotics field medicine. Here, this review analyzes importance health problems systematically summarizes effectiveness mechanisms maintaining treating based on animal models trials. And research outcomes development trends field, challenges prospects their health, alleviating are analyzed. It hoped promote disease treatment open up new frontiers probiotic research.

Язык: Английский

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Unraveling the Puzzle: Health Benefits of Probiotics—A Comprehensive Review

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(5), С. 1436 - 1436

Опубликована: Март 1, 2024

A growing number of probiotic-containing products are on the market, and their use is increasing. Probiotics thought to support health gut microbiota, which in turn might prevent or delay onset gastrointestinal tract disorders. Obesity, type 2 diabetes, autism, osteoporosis, some immunological illnesses among conditions that have been shown possibly benefit from probiotics. In addition ability favorably affect diseases, probiotics represent a defense system enhancing intestinal, nutritional, oral health. Depending microbial strain utilized, can variable beneficial properties. Although many species available, most widely employed ones lactic acid bacteria bifidobacteria. The usefulness these dependent both origin capacity promote valuable clinical tool supporting health, immune function, metabolic balance. When used appropriately, may provide benefits such as reduced risk disorders, enhanced immunity, improved Most popular probiotics, advantages, mode action topic this narrative review article, aimed reader with comprehensive reappraisal matter.

Язык: Английский

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Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5842 - 5842

Опубликована: Май 27, 2024

This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.

Язык: Английский

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An Overview of the Recent Advances in Antimicrobial Resistance

Microorganisms, Год журнала: 2024, Номер 12(9), С. 1920 - 1920

Опубликована: Сен. 21, 2024

Antimicrobial resistance (AMR), frequently considered a major global public health threat, requires comprehensive understanding of its emergence, mechanisms, advances, and implications. AMR’s epidemiological landscape is characterized by widespread prevalence constantly evolving patterns, with multidrug-resistant organisms (MDROs) creating new challenges every day. The most common mechanisms underlying AMR (i.e., genetic mutations, horizontal gene transfer, selective pressure) contribute to the emergence dissemination resistant strains. Therefore, mitigation strategies (e.g., antibiotic stewardship programs—ASPs—and infection prevention control strategies—IPCs) emphasize importance responsible antimicrobial use surveillance. A One Health approach interconnectedness human, animal, environmental health) highlights necessity for interdisciplinary collaboration holistic in combating AMR. Advancements novel therapeutics alternative agents vaccines) offer promising avenues addressing challenges. Policy interventions at international national levels also promote ASPs aiming regulate use. Despite all observed progress, remains pressing concern, demanding sustained efforts address emerging threats sustainability. Future research must prioritize innovative approaches complex socioecological dynamics This manuscript resource researchers, policymakers, healthcare professionals seeking navigate develop effective mitigation.

Язык: Английский

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The Profound Influence of Gut Microbiome and Extracellular Vesicles on Animal Health and Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 4024 - 4024

Опубликована: Апрель 4, 2024

The animal gut microbiota, comprising a diverse array of microorganisms, plays pivotal role in shaping host health and physiology. This review explores the intricate dynamics microbiome animals, focusing on its composition, function, impact host–microbe interactions. composition intestinal microbiota animals is influenced by ecology, including factors such as temperature, pH, oxygen levels, nutrient availability, well genetic makeup, diet, habitat, stressors, husbandry practices. Dysbiosis can lead to various gastrointestinal immune-related issues impacting overall productivity. Extracellular vesicles (EVs), particularly exosomes derived from play crucial intercellular communication, influencing transporting bioactive molecules across barriers like brain barriers. Dysregulation gut–brain axis has implications for disorders highlighting potential microbiota-derived EVs disease progression. Therapeutic approaches modulate probiotics, prebiotics, microbial transplants, phage therapy, offer promising strategies enhancing performance. Studies investigating effects therapy have shown results, with improving food safety poultry production systems. Understanding complex interactions between provides valuable insights into mechanisms underlying their Further research this field essential developing effective therapeutic interventions management promote well-being animals.

Язык: Английский

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A Comprehensive Review of the Triangular Relationship among Diet–Gut Microbiota–Inflammation

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9366 - 9366

Опубликована: Авг. 29, 2024

The human gastrointestinal tract hosts a complex and dynamic community of microorganisms known as the gut microbiota, which play pivotal role in numerous physiological processes, including digestion, metabolism, immune function. Recent research has highlighted significant impact diet on microbiota composition functionality, consequential effects host health. Concurrently, there is growing evidence linking to inflammation, key factor many chronic diseases such inflammatory bowel disease (IBD), obesity, diabetes, cardiovascular (CVDs). This review explores how dietary components influence composition, these microbial changes affect pathways, therapeutic implications modulating this axis for prevention management. Beneficial patterns, Mediterranean (MD) plant-based diets, promote diverse balanced supporting anti-inflammatory pathways. Conversely, Western (WD), high saturated fats refined sugars, associated with dysbiosis increased inflammation. With all links between three variables considered, attempts offer thorough examination triangle formed by food.

Язык: Английский

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Probiotics and Food Bioactives: Unraveling Their Impact on Gut Microbiome, Inflammation, and Metabolic Health

Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Язык: Английский

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A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses

Food Chemistry Advances, Год журнала: 2025, Номер 6, С. 100919 - 100919

Опубликована: Фев. 11, 2025

Язык: Английский

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Beyond the Hayflick limit: How microbes influence cellular aging

Ageing Research Reviews, Год журнала: 2025, Номер 104, С. 102657 - 102657

Опубликована: Янв. 7, 2025

Язык: Английский

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Short-chain fatty acids in nonalcoholic fatty liver disease: New prospects for short-chain fatty acids as therapeutic targets

Heliyon, Год журнала: 2024, Номер 10(5), С. e26991 - e26991

Опубликована: Фев. 27, 2024

Nonalcoholic fatty liver disease (NAFLD) is a stress-induced injury related to heredity, environmental exposure and the gut microbiome metabolism. Short-chain acids (SCFAs), metabolites of microbiota (GM), participate in regulation hepatic steatosis inflammation through gut-liver axis, which play an important role alleviation NAFLD. However, little progress has been made systematically elucidating mechanism how SCFAs improve NAFLD, especially epigenetic mechanisms potential therapeutic application as clinical treatment for Herein, we adopted PubMed Medline search relevant keywords such 'SCFAs', 'NAFLD', 'gut microbiota', 'Epigenetic', 'diet', 'prebiotic effect' review latest research on NAFLD up November 2023. In this review, firstly, specifically discussed production function SCFAs, well their crosstalk coordination axis. Secondly, provided updated summary intensive discussion affect alleviate from perspective genetic epigenetic. Thirdly, paid attention pharmacological physiological characteristics proposed promising future direction adopt alone or combination with prebiotics drugs prevent treat Together, aimed elucidate provide new insights prospects target

Язык: Английский

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