PLoS ONE,
Год журнала:
2024,
Номер
19(12), С. e0315219 - e0315219
Опубликована: Дек. 9, 2024
Septic
shock
is
a
life-threatening
condition
characterized
by
failure
of
organ
systems
and
high
mortality
rate.
Cuproptosis
new
form
cell
death
that
triggered
copper
overload.
However,
the
relationship
between
cuproptosis-related
genes
septic
remains
unclear.
The
GSE26440
dataset
from
GEO
database
was
used
to
screen
differentially
expressed
(DEGs)
control
samples.
Additionally,
hub
related
progression
cuproptosis
were
screened
Venn
analysis.
RT-qPCR
utilized
validate
expression
in
peripheral
blood
lymphocytes
patients
healthy
controls.
Next,
functional
analysis
immune
cells
infiltration
performed.
SLC31A1
MTF1
levels
obviously
elevated
LIAS
LIPT1
downregulated
samples,
compared
normal
diagnostic
values
four
confirmed
with
receiver
operating
characteristic
(ROC)
curves.
showed
positive
correlation
natural
killer
exhibited
CD8+
T
cells.
Furthermore,
low-level
groups,
MAPK
signaling
activated
high-SLC31A1
level
group,
VEGF
high-MTF1
group
lipoic
acid
metabolism
high-LIAS
high-LIPT1
groups.
This
study
demonstrates
SLC31A1,
MTF1,
LIAS,
are
dysregulated
these
exhibit
potential
efficacy
shock,
suggesting
may
be
biomarkers
for
diagnosis
shock.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 20, 2025
Abstract
The
understanding
of
the
mechanisms
that
control
key
features
immune
cells
in
various
disease
contexts
remains
limited,
and
few
techniques
are
available
for
manipulating
cells.
Thus,
discovering
novel
strategies
regulating
is
essential
gaining
insight
into
their
roles
health
disease.
In
this
study,
we
investigated
potential
recently
described
Universal
Receptive
System
to
regulate
human
cell
functions.
This
was
achieved
first
time
by
specifically
targeting
newly
discovered
surface-bound
DNA
RNA-based
receptors
on
leukocytes
generating
“Leukocyte-Tells.”
approach
upregulated
numerous
genes
related
signaling,
migration,
endocytosis,
phagocytosis
pathways.
antimicrobial
anticancer
activities
Leukocyte-Tells
exceeded
activity
vitro
.
some
settings,
such
as
antibiofilm
experiments,
showed
up
1,000,000-fold
higher
than
leukocytes.
Our
findings
reveal,
time,
can
orchestrate
fundamental
properties
cells,
including
enhanced
anti-tumor
activities.
offers
a
new
avenue
biology
regulation
white
blood
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 4, 2025
Pattern
Recognition
Receptors
(PRRs)
are
a
superfamily
of
receptors
that
detect
molecular
structures
typical
for
pathogens
and
damaged
cells
play
crucial
role
in
the
proper
function
innate
immune
system.
A
particular
subgroup
membrane-bound
PRRs
is
represented
by
N-formyl
peptide
(FPRs)
consist
transmembrane
G-protein
coupled
involved
inflammatory
responses.
FPRs
were
initially
described
as
transducers
chemotactic
signals
phagocytes
react
to
tissue
injury.
Subsequently,
also
identified
wide
variety
cell
types,
including
cancer
cells.
Beyond
broad
cellular
distribution,
characterized
ability
bind
ligands
with
different
chemical
biological
properties,
ranging
from
natural
peptides
synthetic
compounds.
The
binding
specific
agonists
induces
cascade
functional
events,
such
proliferation,
migration,
angiogenesis,
oxidative
stress.
From
all
this
evidence,
it
becomes
clear
multifaceted
several
pathophysiological
processes
associated
inflammation.
In
review,
we
provide
comprehensive
description
structure-function
relationship
their
pivotal
host
defense,
highlighting
regulatory
functions
both
initiation
resolution
addition
activity
during
response,
focus
on
involvement
pathological
conditions,
chronic
disease,
neurodegenerative
disorders,
cancer,
special
emphasis
FPR
targeting
promising
therapeutic
strategies
era
precision
medicine.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2501 - 2501
Опубликована: Март 11, 2025
The
increasing
prevalence
of
overweight
and
obesity
not
only
in
adults
but
also
among
children
adolescents
has
become
one
the
most
alarming
health
problems
worldwide.
Metabolic
disorders
accompanying
fat
accumulation
during
pathological
weight
gain
induce
chronic
low-grade
inflammation,
which,
a
vicious
cycle,
increases
immune
response
through
pro-inflammatory
changes
cytokine
(adipokine)
profile.
Obesity
decreases
life
expectancy,
largely
because
obese
individuals
are
at
an
increased
risk
many
medical
complications,
often
referred
to
as
metabolic
syndrome,
which
refers
co-occurrence
insulin
resistance
(IR),
impaired
glucose
tolerance,
type
2
diabetes
(T2D),
atherogenic
dyslipidemia,
hypertension,
premature
ischemic
heart
disease.
Metabotropic
G
protein-coupled
receptors
(GPCRs)
constitute
numerous
diverse
group
cell
surface
transmembrane
eukaryotes.
Among
GPCRs,
researchers
focusing
on
connection
receptor
120
(GPR120),
known
free
fatty
acid
4
(FFAR4),
with
signaling
pathways
regulating
inflammatory
sensitivity.
This
review
presents
current
state
knowledge
concerning
involvement
GPR120
anti-inflammatory
signaling.
Since
both
inflammation
adipose
tissue
key
obesity,
there
is
rationale
for
development
novel,
GPR120-based
therapies
individuals.
main
associated
introducing
this
treatment
into
clinical
practice
discussed.
Globally,
periodontal
diseases,
mainly
driven
by
polymicrobial
biofilms,
are
a
widespread
concern
of
social
medicine
due
to
their
considerable
incidence
and
tie-up
systemic
disorders
like
diabetes,
cardiovascular
complications
during
pregnancy.
Traditional
treatments
focus
on
mechanical
debridement
antimicrobial
therapies,
but
these
approaches
have
limitations,
including
recurrence
antibiotic
resistance.
Periodontal
vaccines
offer
promising
alternative
targeting
the
immunological
mechanisms
underlying
disease.
This
review
explores
current
state
vaccine
development,
highlighting
key
antigens,
delivery
systems,
preclinical
clinical
advancements.
Special
emphasis
is
placed
antigen
selection,
host
variability,
immune
tolerance,
future
directions
overcome
barriers.
article
highlights
advancements
challenges
in
research,
offering
insights
into
capability
immunoprophylaxis
as
groundbreaking
way
manage
diseases.
Abstract
Mycoplasma
bovis
infections
in
cattle
constitute
a
worldwide
problem
with
significant
detrimental
economic
impacts
on
industry.
Mastitis,
pneumonia,
arthritis,
keratoconjunctivitis,
otitis
media
and
genital
disorders
are
its
clinical
manifestations.
Presently,
no
vaccines
commercially
available;
antimicrobial
resistance
is
increasing;
diagnostic
sensitivity
testing
needs
to
be
improved;
new
rapid
diagnosis
kits
eminent
for
implementation
of
treatment
antimicrobials.
We
conducted
systematic
search
databases
such
as
PubMed,
Scopus,
Web
Science,
Google
Scholar,
AGRIS
African
Journals
Online
(AJOL),
from
1995
2024.
Searched
keywords,
as,
bovis,
M
:
vaccine
development,
techniques
strain
variability
using
the
predefined
criteria
were
used
address
review
objectives.
Although
they
have
preventative
function,
–
killed,
live
attenuated,
subunit
types
face
difficulties
because
M.
strains
vary
widely.
Every
approach
has
own
set
benefits
drawbacks,
those
that
been
studies
include
conventional
culture
identification,
serological
testing,
immunohistochemical
demonstration
tissues,
sophisticated
molecular
like
PCR,
qPCR,
next-generation
sequencing.
For
early
detection,
successful
treatment,
vaccination
efficacy
monitoring,
accurate
crucial.
Future
directions
managing
-associated
diseases
improving
accessibility
creating
broad-spectrum
vaccinations.
By
incorporating
these
developments,
it
may
possible
enhance
health
cattle,
promote
sustainability
livestock
production,
increase
food
security.
This
points
urgent
need
further
research
innovation
advancement
support
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
One
of
the
most
potent
therapeutic
and
diagnostic
agents
in
contemporary
medicine
is
monoclonal
antibody
(mAb).
mAbs
can
perform
a
variety
tasks
breast
cancer
(BC),
including
identifying
delivering
medications
to
targets,
preventing
cell
development,
suppressing
immune
system
inhibitors
directly
attacking
cells.
are
one
effective
options,
particularly
for
HER2,
but
they
have
not
been
well
studied
their
use
treating
other
forms
BC,
triple
negative
tumors.
Bispecific
trispecific
created
new
opportunities
more
targeted
specific
efficacy,
which
has
positive
impact
on
viability
antigen
specificity.
They
versatile
than
treatment,
emerging
as
popular
option
BC.
However,
limit
treatment
due
certain
adverse
effects,
fever,
shaking,
exhaustion,
headache,
nausea,
vomiting,
rashes,
bleeding,
difficulty
breathing.
To
examine
current
prospective
future
capacities
with
regard
detection
present
review
highlights
advantages
disadvantages
mAb
approach.
