Identification of cuproptosis-related genes in septic shock based on bioinformatic analysis DOI Creative Commons
Jintong Zhao, Meng Zhang, Ying Wang

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0315219 - e0315219

Published: Dec. 9, 2024

Septic shock is a life-threatening condition characterized by failure of organ systems and high mortality rate. Cuproptosis new form cell death that triggered copper overload. However, the relationship between cuproptosis-related genes septic remains unclear. The GSE26440 dataset from GEO database was used to screen differentially expressed (DEGs) control samples. Additionally, hub related progression cuproptosis were screened Venn analysis. RT-qPCR utilized validate expression in peripheral blood lymphocytes patients healthy controls. Next, functional analysis immune cells infiltration performed. SLC31A1 MTF1 levels obviously elevated LIAS LIPT1 downregulated samples, compared normal diagnostic values four confirmed with receiver operating characteristic (ROC) curves. showed positive correlation natural killer exhibited CD8+ T cells. Furthermore, low-level groups, MAPK signaling activated high-SLC31A1 level group, VEGF high-MTF1 group lipoic acid metabolism high-LIAS high-LIPT1 groups. This study demonstrates SLC31A1, MTF1, LIAS, are dysregulated these exhibit potential efficacy shock, suggesting may be biomarkers for diagnosis shock.

Language: Английский

A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses DOI Creative Commons
Alice Njolke Mafe, Great Iruoghene Edo,

Osamah S. Majeed

et al.

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

Citations

4
Integrative bioinformatics analysis reveals CGAS as a ferroptosis-related signature gene in sepsis and screens the potential natural inhibitors of CGAS DOI
Jiaxi Chen,

Mingmei Feng,

Tianyao Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139778 - 139778

Published: Jan. 1, 2025

Language: Английский

Citations

0
Regulating white blood cell activity through the novel Universal Receptive System DOI Open Access
Victor Tetz,

Kristina Kardava,

Maria Vecherkovskaya

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract The understanding of the mechanisms that control key features immune cells in various disease contexts remains limited, and few techniques are available for manipulating cells. Thus, discovering novel strategies regulating is essential gaining insight into their roles health disease. In this study, we investigated potential recently described Universal Receptive System to regulate human cell functions. This was achieved first time by specifically targeting newly discovered surface-bound DNA RNA-based receptors on leukocytes generating “Leukocyte-Tells.” approach upregulated numerous genes related signaling, migration, endocytosis, phagocytosis pathways. antimicrobial anticancer activities Leukocyte-Tells exceeded activity vitro . some settings, such as antibiofilm experiments, showed up 1,000,000-fold higher than leukocytes. Our findings reveal, time, can orchestrate fundamental properties cells, including enhanced anti-tumor activities. offers a new avenue biology regulation white blood

Language: Английский

Citations

0
Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders DOI
Azhagu Madhavan Sivalingam

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: Feb. 11, 2025

Language: Английский

Citations

0
The N-formyl peptide receptors: much more than chemoattractant receptors. Relevance in health and disease DOI Creative Commons
Filomena Napolitano, Nunzia Montuori

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 4, 2025

Pattern Recognition Receptors (PRRs) are a superfamily of receptors that detect molecular structures typical for pathogens and damaged cells play crucial role in the proper function innate immune system. A particular subgroup membrane-bound PRRs is represented by N-formyl peptide (FPRs) consist transmembrane G-protein coupled involved inflammatory responses. FPRs were initially described as transducers chemotactic signals phagocytes react to tissue injury. Subsequently, also identified wide variety cell types, including cancer cells. Beyond broad cellular distribution, characterized ability bind ligands with different chemical biological properties, ranging from natural peptides synthetic compounds. The binding specific agonists induces cascade functional events, such proliferation, migration, angiogenesis, oxidative stress. From all this evidence, it becomes clear multifaceted several pathophysiological processes associated inflammation. In review, we provide comprehensive description structure-function relationship their pivotal host defense, highlighting regulatory functions both initiation resolution addition activity during response, focus on involvement pathological conditions, chronic disease, neurodegenerative disorders, cancer, special emphasis FPR targeting promising therapeutic strategies era precision medicine.

Language: Английский

Citations

0
Potential Therapeutic Exploitation of G Protein-Coupled Receptor 120 (GPR120/FFAR4) Signaling in Obesity-Related Metabolic Disorders DOI Open Access
Dariusz Szukiewicz

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2501 - 2501

Published: March 11, 2025

The increasing prevalence of overweight and obesity not only in adults but also among children adolescents has become one the most alarming health problems worldwide. Metabolic disorders accompanying fat accumulation during pathological weight gain induce chronic low-grade inflammation, which, a vicious cycle, increases immune response through pro-inflammatory changes cytokine (adipokine) profile. Obesity decreases life expectancy, largely because obese individuals are at an increased risk many medical complications, often referred to as metabolic syndrome, which refers co-occurrence insulin resistance (IR), impaired glucose tolerance, type 2 diabetes (T2D), atherogenic dyslipidemia, hypertension, premature ischemic heart disease. Metabotropic G protein-coupled receptors (GPCRs) constitute numerous diverse group cell surface transmembrane eukaryotes. Among GPCRs, researchers focusing on connection receptor 120 (GPR120), known free fatty acid 4 (FFAR4), with signaling pathways regulating inflammatory sensitivity. This review presents current state knowledge concerning involvement GPR120 anti-inflammatory signaling. Since both inflammation adipose tissue key obesity, there is rationale for development novel, GPR120-based therapies individuals. main associated introducing this treatment into clinical practice discussed.

Language: Английский

Citations

0
A Narrative Review of Periodontal Vaccines: Hope or Hype? DOI Open Access
Pratiksha Patel, Bhavin Patel,

Siddharth Vyas

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Globally, periodontal diseases, mainly driven by polymicrobial biofilms, are a widespread concern of social medicine due to their considerable incidence and tie-up systemic disorders like diabetes, cardiovascular complications during pregnancy. Traditional treatments focus on mechanical debridement antimicrobial therapies, but these approaches have limitations, including recurrence antibiotic resistance. Periodontal vaccines offer promising alternative targeting the immunological mechanisms underlying disease. This review explores current state vaccine development, highlighting key antigens, delivery systems, preclinical clinical advancements. Special emphasis is placed antigen selection, host variability, immune tolerance, future directions overcome barriers. article highlights advancements challenges in research, offering insights into capability immunoprophylaxis as groundbreaking way manage diseases.

Language: Английский

Citations

0
MicroRNAs in transplant rejection: Emerging roles in immune regulation and applications DOI
Shaochen Yu, Jian Lu

Transplant Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 102222 - 102222

Published: March 1, 2025

Language: Английский

Citations

0
Mycoplasma bovis : A review of vaccination and diagnostic initiatives DOI

Isaac Dayo Olorunshola,

Kabiru Ahmad, A.R. Peters

et al.

CABI Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract Mycoplasma bovis infections in cattle constitute a worldwide problem with significant detrimental economic impacts on industry. Mastitis, pneumonia, arthritis, keratoconjunctivitis, otitis media and genital disorders are its clinical manifestations. Presently, no vaccines commercially available; antimicrobial resistance is increasing; diagnostic sensitivity testing needs to be improved; new rapid diagnosis kits eminent for implementation of treatment antimicrobials. We conducted systematic search databases such as PubMed, Scopus, Web Science, Google Scholar, AGRIS African Journals Online (AJOL), from 1995 2024. Searched keywords, as, bovis, M : vaccine development, techniques strain variability using the predefined criteria were used address review objectives. Although they have preventative function, – killed, live attenuated, subunit types face difficulties because M. strains vary widely. Every approach has own set benefits drawbacks, those that been studies include conventional culture identification, serological testing, immunohistochemical demonstration tissues, sophisticated molecular like PCR, qPCR, next-generation sequencing. For early detection, successful treatment, vaccination efficacy monitoring, accurate crucial. Future directions managing -associated diseases improving accessibility creating broad-spectrum vaccinations. By incorporating these developments, it may possible enhance health cattle, promote sustainability livestock production, increase food security. This points urgent need further research innovation advancement support

Language: Английский

Citations

0
Monoclonal Antibodies in Clinical Trials for Breast Cancer Treatment DOI
Rahaman Shaik,

V. Pavani Sai Mounika,

S. Begum

et al.

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

One of the most potent therapeutic and diagnostic agents in contemporary medicine is monoclonal antibody (mAb). mAbs can perform a variety tasks breast cancer (BC), including identifying delivering medications to targets, preventing cell development, suppressing immune system inhibitors directly attacking cells. are one effective options, particularly for HER2, but they have not been well studied their use treating other forms BC, triple negative tumors. Bispecific trispecific created new opportunities more targeted specific efficacy, which has positive impact on viability antigen specificity. They versatile than treatment, emerging as popular option BC. However, limit treatment due certain adverse effects, fever, shaking, exhaustion, headache, nausea, vomiting, rashes, bleeding, difficulty breathing. To examine current prospective future capacities with regard detection present review highlights advantages disadvantages mAb approach.

Language: Английский

Citations

0