PLoS ONE,
Год журнала:
2024,
Номер
19(12), С. e0315219 - e0315219
Опубликована: Дек. 9, 2024
Septic
shock
is
a
life-threatening
condition
characterized
by
failure
of
organ
systems
and
high
mortality
rate.
Cuproptosis
new
form
cell
death
that
triggered
copper
overload.
However,
the
relationship
between
cuproptosis-related
genes
septic
remains
unclear.
The
GSE26440
dataset
from
GEO
database
was
used
to
screen
differentially
expressed
(DEGs)
control
samples.
Additionally,
hub
related
progression
cuproptosis
were
screened
Venn
analysis.
RT-qPCR
utilized
validate
expression
in
peripheral
blood
lymphocytes
patients
healthy
controls.
Next,
functional
analysis
immune
cells
infiltration
performed.
SLC31A1
MTF1
levels
obviously
elevated
LIAS
LIPT1
downregulated
samples,
compared
normal
diagnostic
values
four
confirmed
with
receiver
operating
characteristic
(ROC)
curves.
showed
positive
correlation
natural
killer
exhibited
CD8+
T
cells.
Furthermore,
low-level
groups,
MAPK
signaling
activated
high-SLC31A1
level
group,
VEGF
high-MTF1
group
lipoic
acid
metabolism
high-LIAS
high-LIPT1
groups.
This
study
demonstrates
SLC31A1,
MTF1,
LIAS,
are
dysregulated
these
exhibit
potential
efficacy
shock,
suggesting
may
be
biomarkers
for
diagnosis
shock.
World Journal of Transplantation,
Год журнала:
2025,
Номер
15(3)
Опубликована: Апрель 18, 2025
Organ
transplantation
has
long
been
recognized
as
an
effective
treatment
for
end-stage
organ
failure,
metabolic
diseases,
and
malignant
tumors.
However,
graft
rejection
caused
by
major
histocompatibility
complex
mismatch
remains
a
significant
challenge.
While
modern
immunosuppressants
have
made
strides
in
reducing
the
incidence
risk
of
rejection,
they
not
able
to
eliminate
it
completely.
The
intricate
mechanisms
underlying
transplant
subject
intense
investigation
immunologists.
Among
these
factors,
autophagy
emerged
key
player.
Autophagy
is
evolutionarily
conserved
mechanism
eukaryotic
cells
that
mediates
autophagocytosis
cellular
protection.
This
process
regulated
autophagy-related
genes
their
encoded
protein
families,
which
maintain
material
energetic
balance
within
cells.
Additionally,
reported
play
crucial
roles
development,
maturation,
differentiation,
responses
immune
In
environment
following
transplantation,
role
are
gradually
being
revealed.
this
review,
we
aim
explore
current
understanding
solid
after
transplantation.
Furthermore,
delve
into
therapeutic
advancements
achieved
targeting
involved
process.
ABSTRACT
Infections
with
Mycobacterium
tuberculosis
(Mtb)
resulted
in
over
one
million
deaths
2024,
the
highest
number
for
any
infectious
disease.
With
no
vaccines
that
protect
against
pulmonary
(TB)
and
challenges
associated
antibiotic
therapy,
there
is
a
critical
need
to
better
understand
host-Mtb
interactions
help
curb
this
major
public
health
problem.
Mtb
arguably
most
successful
human
pathogen,
it
survives
diverse
environments,
resulting
heterogeneous
disease
outcomes
patients.
Five
years
ago,
my
commentary
mSphere,
I
discussed
how
virulence
strategies
sense,
adapt,
evade
killing
host
can
be
uncovered
using
genetic
approaches.
Here,
will
come
full
circle
highlight
approaches
recently
new
mechanisms
regulating
protective
responses
survival
tactics.
The
goal
framework
probe
range
of
unexplored
phenotypes,
increase
our
understanding
interactions,
identify
therapeutic
targets
may
prevent
TB.
Vaccines,
Год журнала:
2024,
Номер
12(10), С. 1195 - 1195
Опубликована: Окт. 19, 2024
The
accumulation
of
specific
IgG
antibodies
in
blood
serum
is
considered
a
key
criterion
for
the
effectiveness
vaccination.
For
several
vaccine-preventable
infections,
quantitative
indicators
humoral
response
have
been
established,
which,
when
reached,
provide
high
probability
protection
against
infection.
presence
such
formal
correlate
vaccine
crucial,
example,
organizing
preventive
measures
and
validating
newly
developed
vaccines.
However,
can
effective
infection
occur
level
lower
than
that
provided
by
parenteral
vaccination?
Will
be
sufficient
if
same
antigen
administered
via
mucosal
membranes
without
achieving
levels
circulating
blood?
Gram-negative
bacteria
are
the
main
bacterial
pathogens
infecting
Chinese
giant
salamanders
(Andrias
davidianus;
CGS)
in
captivity
and
wild,
causing
substantial
economic
losses
CGS
industry.
However,
molecular
mechanisms
underlying
pathogenesis
following
infection
remain
unclear.
PLoS ONE,
Год журнала:
2024,
Номер
19(12), С. e0315219 - e0315219
Опубликована: Дек. 9, 2024
Septic
shock
is
a
life-threatening
condition
characterized
by
failure
of
organ
systems
and
high
mortality
rate.
Cuproptosis
new
form
cell
death
that
triggered
copper
overload.
However,
the
relationship
between
cuproptosis-related
genes
septic
remains
unclear.
The
GSE26440
dataset
from
GEO
database
was
used
to
screen
differentially
expressed
(DEGs)
control
samples.
Additionally,
hub
related
progression
cuproptosis
were
screened
Venn
analysis.
RT-qPCR
utilized
validate
expression
in
peripheral
blood
lymphocytes
patients
healthy
controls.
Next,
functional
analysis
immune
cells
infiltration
performed.
SLC31A1
MTF1
levels
obviously
elevated
LIAS
LIPT1
downregulated
samples,
compared
normal
diagnostic
values
four
confirmed
with
receiver
operating
characteristic
(ROC)
curves.
showed
positive
correlation
natural
killer
exhibited
CD8+
T
cells.
Furthermore,
low-level
groups,
MAPK
signaling
activated
high-SLC31A1
level
group,
VEGF
high-MTF1
group
lipoic
acid
metabolism
high-LIAS
high-LIPT1
groups.
This
study
demonstrates
SLC31A1,
MTF1,
LIAS,
are
dysregulated
these
exhibit
potential
efficacy
shock,
suggesting
may
be
biomarkers
for
diagnosis
shock.
