Role of autophagy in rejection after solid organ transplantation: A systematic review of the literature

World Journal of Transplantation, Journal Year: 2025, Volume and Issue: 15(3)

Published: April 18, 2025

Organ transplantation has long been recognized as an effective treatment for end-stage organ failure, metabolic diseases, and malignant tumors. However, graft rejection caused by major histocompatibility complex mismatch remains a significant challenge. While modern immunosuppressants have made strides in reducing the incidence risk of rejection, they not able to eliminate it completely. The intricate mechanisms underlying transplant subject intense investigation immunologists. Among these factors, autophagy emerged key player. Autophagy is evolutionarily conserved mechanism eukaryotic cells that mediates autophagocytosis cellular protection. This process regulated autophagy-related genes their encoded protein families, which maintain material energetic balance within cells. Additionally, reported play crucial roles development, maturation, differentiation, responses immune In environment following transplantation, role are gradually being revealed. this review, we aim explore current understanding solid after transplantation. Furthermore, delve into therapeutic advancements achieved targeting involved process.

Language: Английский

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Using host and bacterial genetic approaches to define virulence strategies and protective immunity during Mycobacterium tuberculosis infection

mSphere, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT Infections with Mycobacterium tuberculosis (Mtb) resulted in over one million deaths 2024, the highest number for any infectious disease. With no vaccines that protect against pulmonary (TB) and challenges associated antibiotic therapy, there is a critical need to better understand host-Mtb interactions help curb this major public health problem. Mtb arguably most successful human pathogen, it survives diverse environments, resulting heterogeneous disease outcomes patients. Five years ago, my commentary mSphere, I discussed how virulence strategies sense, adapt, evade killing host can be uncovered using genetic approaches. Here, will come full circle highlight approaches recently new mechanisms regulating protective responses survival tactics. The goal framework probe range of unexplored phenotypes, increase our understanding interactions, identify therapeutic targets may prevent TB.

Language: Английский

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MAVS: The Next STING in Cancers and Other Diseases

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: unknown, P. 104610 - 104610

Published: Dec. 1, 2024

Language: Английский

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Comparative Efficacy of Parenteral and Mucosal Recombinant Probiotic Vaccines Against SARS-CoV-2 and S. pneumoniae Infections in Animal Models

Vaccines, Journal Year: 2024, Volume and Issue: 12(10), P. 1195 - 1195

Published: Oct. 19, 2024

The accumulation of specific IgG antibodies in blood serum is considered a key criterion for the effectiveness vaccination. For several vaccine-preventable infections, quantitative indicators humoral response have been established, which, when reached, provide high probability protection against infection. presence such formal correlate vaccine crucial, example, organizing preventive measures and validating newly developed vaccines. However, can effective infection occur level lower than that provided by parenteral vaccination? Will be sufficient if same antigen administered via mucosal membranes without achieving levels circulating blood?

Language: Английский

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Transcriptomic analysis of spleen-derived macrophages in response to lipopolysaccharide shows dependency on the MyD88-independent pathway in Chinese giant salamanders (Andrias davidianus)

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Oct. 28, 2024

Gram-negative bacteria are the main bacterial pathogens infecting Chinese giant salamanders (Andrias davidianus; CGS) in captivity and wild, causing substantial economic losses CGS industry. However, molecular mechanisms underlying pathogenesis following infection remain unclear.

Language: Английский

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Identification of cuproptosis-related genes in septic shock based on bioinformatic analysis

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0315219 - e0315219

Published: Dec. 9, 2024

Septic shock is a life-threatening condition characterized by failure of organ systems and high mortality rate. Cuproptosis new form cell death that triggered copper overload. However, the relationship between cuproptosis-related genes septic remains unclear. The GSE26440 dataset from GEO database was used to screen differentially expressed (DEGs) control samples. Additionally, hub related progression cuproptosis were screened Venn analysis. RT-qPCR utilized validate expression in peripheral blood lymphocytes patients healthy controls. Next, functional analysis immune cells infiltration performed. SLC31A1 MTF1 levels obviously elevated LIAS LIPT1 downregulated samples, compared normal diagnostic values four confirmed with receiver operating characteristic (ROC) curves. showed positive correlation natural killer exhibited CD8+ T cells. Furthermore, low-level groups, MAPK signaling activated high-SLC31A1 level group, VEGF high-MTF1 group lipoic acid metabolism high-LIAS high-LIPT1 groups. This study demonstrates SLC31A1, MTF1, LIAS, are dysregulated these exhibit potential efficacy shock, suggesting may be biomarkers for diagnosis shock.

Language: Английский

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