Exploring the Functionality of the Krüppel-like Factors in Kidney Development, Metabolism, and Diseases DOI Creative Commons

Itzel Salmon-Cabrales,

David A. de la Garza-Kalife,

Gabriel García-González

и другие.

Life, Год журнала: 2024, Номер 14(12), С. 1671 - 1671

Опубликована: Дек. 17, 2024

The kidneys contribute to the overall health of an organism by maintaining systemic homeostasis. This process involves various biological mechanisms, in which Krüppel-like factors (KLFs), a family transcription factors, are essential for regulating development, differentiation, proliferation, and cellular apoptosis. They also play role metabolic regulation nutrients, such as glucose lipids. dysregulation these is associated with development pathologies, can ultimately lead renal fibrosis, severely compromising kidney function. In this context, present article provides comprehensive review existing literature, offering enriching analysis findings related KLFs nephrology, while highlighting their potential therapeutic treatment diseases.

Язык: Английский

Molecular mechanisms of transcription factor KLF4-mediated immune infiltration influencing lung adenocarcinoma invasion DOI
Kaining Jia,

Yiwen Na,

Qiang Lin

и другие.

Cytokine, Год журнала: 2025, Номер 187, С. 156848 - 156848

Опубликована: Янв. 11, 2025

Язык: Английский

Процитировано

0
Zinc fingers are responsible for the efficient control of KLF7 on the transcription of genes in the NF-κB signaling pathway and fatty acid β-oxidation DOI Creative Commons

Jiazhen Tian,

Tingting Zhang, Zhen Qi

и другие.

Acta Biochimica et Biophysica Sinica, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Exploring the Functionality of the Krüppel-like Factors in Kidney Development, Metabolism, and Diseases DOI Creative Commons

Itzel Salmon-Cabrales,

David A. de la Garza-Kalife,

Gabriel García-González

и другие.

Life, Год журнала: 2024, Номер 14(12), С. 1671 - 1671

Опубликована: Дек. 17, 2024

The kidneys contribute to the overall health of an organism by maintaining systemic homeostasis. This process involves various biological mechanisms, in which Krüppel-like factors (KLFs), a family transcription factors, are essential for regulating development, differentiation, proliferation, and cellular apoptosis. They also play role metabolic regulation nutrients, such as glucose lipids. dysregulation these is associated with development pathologies, can ultimately lead renal fibrosis, severely compromising kidney function. In this context, present article provides comprehensive review existing literature, offering enriching analysis findings related KLFs nephrology, while highlighting their potential therapeutic treatment diseases.

Язык: Английский

Процитировано

0