Exploring the Functionality of the Krüppel-like Factors in Kidney Development, Metabolism, and Diseases DOI Creative Commons

Itzel Salmon-Cabrales,

David A. de la Garza-Kalife,

Gabriel García-González

et al.

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1671 - 1671

Published: Dec. 17, 2024

The kidneys contribute to the overall health of an organism by maintaining systemic homeostasis. This process involves various biological mechanisms, in which Krüppel-like factors (KLFs), a family transcription factors, are essential for regulating development, differentiation, proliferation, and cellular apoptosis. They also play role metabolic regulation nutrients, such as glucose lipids. dysregulation these is associated with development pathologies, can ultimately lead renal fibrosis, severely compromising kidney function. In this context, present article provides comprehensive review existing literature, offering enriching analysis findings related KLFs nephrology, while highlighting their potential therapeutic treatment diseases.

Language: Английский

Molecular mechanisms of transcription factor KLF4-mediated immune infiltration influencing lung adenocarcinoma invasion DOI
Kaining Jia,

Yiwen Na,

Qiang Lin

et al.

Cytokine, Journal Year: 2025, Volume and Issue: 187, P. 156848 - 156848

Published: Jan. 11, 2025

Language: Английский

Citations

0
Zinc fingers are responsible for the efficient control of KLF7 on the transcription of genes in the NF-κB signaling pathway and fatty acid β-oxidation DOI Creative Commons

Jiazhen Tian,

Tingting Zhang, Zhen Qi

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Exploring the Functionality of the Krüppel-like Factors in Kidney Development, Metabolism, and Diseases DOI Creative Commons

Itzel Salmon-Cabrales,

David A. de la Garza-Kalife,

Gabriel García-González

et al.

Life, Journal Year: 2024, Volume and Issue: 14(12), P. 1671 - 1671

Published: Dec. 17, 2024

The kidneys contribute to the overall health of an organism by maintaining systemic homeostasis. This process involves various biological mechanisms, in which Krüppel-like factors (KLFs), a family transcription factors, are essential for regulating development, differentiation, proliferation, and cellular apoptosis. They also play role metabolic regulation nutrients, such as glucose lipids. dysregulation these is associated with development pathologies, can ultimately lead renal fibrosis, severely compromising kidney function. In this context, present article provides comprehensive review existing literature, offering enriching analysis findings related KLFs nephrology, while highlighting their potential therapeutic treatment diseases.

Language: Английский

Citations

0