Parkinson’s Disease Is Predominantly an Environmental Disease

Journal of Parkinson s Disease, Год журнала: 2024, Номер 14(3), С. 451 - 465

Опубликована: Янв. 12, 2024

Parkinson’s disease is the world’s fastest growing brain disorder, and exposure to environmental toxicants principal reason. In this paper, we consider alternative, but unsatisfactory, explanations for its rise, including improved diagnostic skills, aging populations, genetic causes. We then detail three that are likely among main causes of disease— certain pesticides, solvent trichloroethylene, air pollution. All ubiquitous, many affect mitochondrial functioning, all can access humans via various routes, inhalation ingestion. reach hopeful conclusion most thus preventable help create a world where increasingly rare.

Язык: Английский

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Epidemiology of Parkinson’s Disease: An Update

Current Neurology and Neuroscience Reports, Год журнала: 2024, Номер 24(6), С. 163 - 179

Опубликована: Апрель 20, 2024

Язык: Английский

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The impact of air pollution on neurodegenerative diseases: a narrative review of current evidence

The Egyptian Journal of Internal Medicine, Год журнала: 2025, Номер 37(1)

Опубликована: Янв. 24, 2025

Abstract This narrative review explores the relationship between air pollution and neurodegenerative diseases (NDs). Historically, has been linked primarily to respiratory cardiovascular issues, but recent evidence suggests that it may also impact neurological health. With global increase in diseases, understanding environmental risk factors become crucial. The synthesizes findings from studies, highlighting potential role of pollutants—particularly fine particulate matter (PM2.5), ozone, nitrogen dioxide (NO2), heavy metals—in onset progression NDs. Key mechanisms under investigation include brain inflammation microglial activation, which are believed contribute processes. Animal human studies have shown correlations exposure increased cognitive decline disorders. Research indicates exacerbate neuroinflammation cause white abnormalities, disrupt neural communication function. Additionally, emerging like residential greenness climate action could mitigate some these adverse effects. Despite advancements, significant knowledge gaps remain, particularly regarding long-term chronic specific molecular pathways involved. shows need for further research clarify develop targeted interventions. Addressing pollution’s on requires comprehensive public health strategies, including stricter regulations awareness, alongside continued into preventive therapeutic measures.

Язык: Английский

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Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease

Nature Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Язык: Английский

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Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson’s disease

npj Parkinson s Disease, Год журнала: 2023, Номер 9(1)

Опубликована: Июль 13, 2023

The biological basis of the neurodegenerative movement disorder, Parkinson's disease (PD), is still unclear despite it being 'discovered' over 200 years ago in Western Medicine. Based on current PD knowledge, there are widely varying theories as to its pathobiology. aim this article was explore some these different by summarizing viewpoints laboratory and clinician scientists field, disease. To achieve aim, we posed question thirteen "PD experts" from six continents (for global representation) collated their personal opinions into article. views were varied, ranging toxin exposure a trigger, LRRK2 potential root cause, toxic alpha-synuclein most important etiological contributor. Notably, also growing recognition that definition single should be reconsidered, perhaps each with own unique pathobiology treatment regimen.

Язык: Английский

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Particulate matter exposure and neurodegenerative diseases: A comprehensive update on toxicity and mechanisms

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 266, С. 115565 - 115565

Опубликована: Окт. 11, 2023

Exposure to particulate matter (PM) has been associated with a range of health impacts, including neurological abnormalities that affect neurodevelopment, neuroplasticity, and behavior. Recently, there growing interest in investigating the possible relationship between PM exposure onset progression neurodegenerative diseases, such as Alzheimer's disease, Parkinson's Huntington's multiple sclerosis. However, precise mechanism by which affects neurodegeneration is still unclear, even though several epidemiological animal model studies have provided mechanistic insights. This article presents review current research on neurotoxicity its impact diseases. summarizes findings from collected through searches Google Scholar, PubMed, Web Science, Scopus. paper also discusses reported effects central nervous system highlights gaps future directions. The information presented this may inform public policies aimed at reducing contribute development new treatments for Further therapeutic will be needed fully understand

Язык: Английский

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Crosstalk between Oxidative Stress and Inflammation Caused by Noise and Air Pollution—Implications for Neurodegenerative Diseases

Antioxidants, Год журнала: 2024, Номер 13(3), С. 266 - 266

Опубликована: Фев. 22, 2024

Neurodegenerative diseases are often referred to as of old age, and with the aging population, they gaining scientific medical interest. Environmental stressors, most notably traffic noise air pollution, have recently come forefront, emerged disease risk factors. The evidence for a connection between environmental factors neurodegenerative is growing. In this review, common their epidemiological association pollution presented. Also, important mechanisms involved in development, oxidative stress, neuroinflammation highlighted. An overview vivo findings will provide mechanistic link noise, pathology. Finally, importance direct indirect pathways, by which cause cerebral damage, discussed. More high-quality data still needed from both basic science studies order better understand causal

Язык: Английский

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Particulate Matter-Induced Emerging Health Effects Associated with Oxidative Stress and Inflammation

Antioxidants, Год журнала: 2024, Номер 13(10), С. 1256 - 1256

Опубликована: Окт. 17, 2024

Environmental pollution continues to increase with industrial development and has become a threat human health. Atmospheric particulate matter (PM) was designated as Group 1 carcinogen by the International Agency for Research on Cancer in 2013 is an emerging global environmental risk factor that major cause of death related cardiovascular respiratory diseases. PM complex composed highly reactive organic matter, chemicals, metal components, which mainly excessive production oxygen species (ROS) can lead DNA cell damage, endoplasmic reticulum stress, inflammatory responses, atherosclerosis, airway remodeling, contributing increased susceptibility exacerbation various diseases infections. effects health depending particle size, physical chemical characteristics, source, exposure period. smaller than 5 μm penetrate accumulate alveoli circulatory system, causing harmful skin, brain. In this review, we describe relationship mechanism ROS-mediated oxidative responses caused organs, well comprehensively discuss harmfulness PM.

Язык: Английский

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Ambient particulate matter exposure induces ferroptosis in hippocampal cells through the GSK3B/Nrf2/GPX4 pathway

Free Radical Biology and Medicine, Год журнала: 2024, Номер 213, С. 359 - 370

Опубликована: Янв. 28, 2024

Язык: Английский

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Functional identification of long non-coding RNAs induced by PM2.5 in microglia through microarray analysis

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 273, С. 116136 - 116136

Опубликована: Фев. 21, 2024

As a dominating air pollutant, atmospheric fine particulate matter within 2.5 μm in diameter (PM2.5) has attracted increasing attention from the researchers all over world, which will lead to various adverse effects on central nervous system (CNS), yet potential mechanism is unclear. In this study, microglia (BV2 cell line) were exposed different concentrations of PM2.5 (5, 10 and 20 μg/cm2) for 24 h. It was found that could result such as decreased viability, structural damage even death. And it reported long non-coding RNAs (lncRNAs) participate multitudinous neurological diseases. Therefore, microarray analysis conducted order disclose underlying neurotoxicity by ascertaining differentially expressed lncRNAs (DElncRNAs). The consequences indicated DElncRNAs enriched biological pathways, including ferroptosis, IL-17 signaling pathway NOD-like receptor pathway. Moreover, cis- trans-regulated mRNAs well corresponding transcriptional factors (TFs) observed, CEBPA, MYC, MEIS1 KLF4. summary, our study supplies some candidate libraries preventive target against PM2.5-induced toxicity through targeting lncRNAs. Furthermore, post-transcriptional regulation contribute future research neurotoxicity.

Язык: Английский

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