Metabolites,
Год журнала:
2021,
Номер
11(12), С. 840 - 840
Опубликована: Дек. 4, 2021
In
recent
decades,
the
worldwide
prevalence
of
obesity
has
risen
dramatically
and
is
currently
estimated
to
be
around
20%.
Obesity
linked
an
increased
risk
comorbidities
premature
mortality.
Several
studies
have
shown
that
negatively
impacts
male
fertility
through
various
mechanisms.
This
review
aims
investigate
molecular
mechanisms
which
impairs
reproduction,
including
obesity-associated
hypogonadism
its
effects
on
spermatogenesis,
chronic
inflammation,
oxidative
stress.
both
conventional
biofunctional
sperm
parameters,
it
also
induces
epigenetic
changes
can
transferred
offspring.
Moreover,
obesity-related
diseases
are
a
dysregulation
adipocyte
function
micro-environmental
inflammatory
processes.
The
dysregulated
adipokines
significantly
influence
insulin
signaling,
they
may
detrimental
effect
testicular
function.
Sirtuins
play
important
role
in
metabolic
responses
obese
patients.
Understanding
involved
obesity-induced
infertility
could
increase
our
ability
identify
novel
targets
for
prevention
treatment
related
consequences.
New England Journal of Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
No
medications
are
currently
approved
for
the
treatment
of
nonmonogenic,
nonsyndromic
obesity
in
children
younger
than
12
years
age.
Although
use
liraglutide
has
been
shown
to
induce
weight
loss
adults
and
adolescents
with
obesity,
its
safety
efficacy
have
not
established
children.
Obesity,
Год журнала:
2020,
Номер
28(3), С. 484 - 492
Опубликована: Фев. 24, 2020
Objective
Obesity
is
responsible
for
a
huge
burden
of
suffering
and
social
costs,
yet
many
patients
lack
access
to
evidence‐based
therapies.
The
diagnostic
term
“obesity”
inadequate
International
Classification
Diseases
(ICD)
codes
contribute
suboptimal
efforts
prevent
treat
obesity
as
chronic
disease.
goal
this
review
develop
medically
actionable
classification
system
based
on
the
“adiposity‐based
disease”
(ABCD)
that
reflects
disease
pathophysiology
specific
complications
causing
morbidity
mortality.
Methods
A
coding
diagnosis
ABCD
with
four
domains
proposed:
reflect
pathophysiology,
B
indicate
BMI
classification,
C
specify
biomechanical
cardiovascular
remediable
by
weight
loss,
D
degree
severity
complications.
Supplemental
identify
aggravating
factors
complicate
care
are
relevant
personalized
therapeutic
plan.
Results
addresses
goals
differential
risk,
presence,
integral
Conclusions
scientifically
correct
approach
will
lead
greater
acknowledgement
accessibility
therapies
behalf
across
life
cycle.
Metabolites,
Год журнала:
2021,
Номер
11(12), С. 840 - 840
Опубликована: Дек. 4, 2021
In
recent
decades,
the
worldwide
prevalence
of
obesity
has
risen
dramatically
and
is
currently
estimated
to
be
around
20%.
Obesity
linked
an
increased
risk
comorbidities
premature
mortality.
Several
studies
have
shown
that
negatively
impacts
male
fertility
through
various
mechanisms.
This
review
aims
investigate
molecular
mechanisms
which
impairs
reproduction,
including
obesity-associated
hypogonadism
its
effects
on
spermatogenesis,
chronic
inflammation,
oxidative
stress.
both
conventional
biofunctional
sperm
parameters,
it
also
induces
epigenetic
changes
can
transferred
offspring.
Moreover,
obesity-related
diseases
are
a
dysregulation
adipocyte
function
micro-environmental
inflammatory
processes.
The
dysregulated
adipokines
significantly
influence
insulin
signaling,
they
may
detrimental
effect
testicular
function.
Sirtuins
play
important
role
in
metabolic
responses
obese
patients.
Understanding
involved
obesity-induced
infertility
could
increase
our
ability
identify
novel
targets
for
prevention
treatment
related
consequences.
