Journal of the European Academy of Dermatology and Venereology,
Год журнала:
2022,
Номер
36(7), С. 987 - 1002
Опубликована: Март 12, 2022
Rosacea
and
demodicosis
are
common
facial
conditions
in
dermatology
practice.
While
is
clearly
the
result
of
Demodex
mite
infestation,
pathogenicity
rosacea
still
not
sufficiently
explained,
so
that
it
defined
by
its
symptoms,
cause.
It
usually
considered
as
a
disease
immune
system
associated
with
neurogenic
inflammation
triggered
various
factors
(ultraviolet
light,
heat,
spicy
food,
alcohol,
stress
microorganisms).
Its
links
remain
controversial,
although
there
increasing
evidence
mites
may
play
key
role
inflammatory
process.
Indeed,
high
densities
observed
nearly
all
cases
papulopustules
(PPR)
can
be
effectively
treated
topical
acaricidal
agents.
Recent
studies
suggest
induces
two
opposite
actions
on
host
immunity:
defensive
response
aimed
at
eliminating
an
immunosuppressive
action
favouring
own
proliferation.
Moreover,
initial
likely
diverted
towards
benefit
for
mite,
via
T-cell
exhaustion
induced
properties
vascular
endothelial
growth
factor,
which
also
explain
favourable
influence
altered
background
seems
to
exert
In
this
review,
against
causal
discussed,
applying
three
systems
traditionally
used
attribute
causality
(modified
Koch
criteria,
Hill
criteria
Rothman
model).
The
findings
PPR
reasonably
attributed
proliferation,
appears
necessary
factor
centre
network
multiple
co-factors
interact
occurrence
severity
from
limited
(pityriasis
folliculorum)
more
marked
(PPR).
could,
therefore,
chronic
infection
exhaustion.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Июнь 23, 2022
Systemic
sclerosis
(SSc)
is
a
rare
fibrotic
rheumatic
disease,
associated
with
psychological
distress
and
increased
morbidity
mortality
due
to
skin
involvement
internal
organ
damage.
The
current
understanding
of
the
complex
pathogenesis
yet
incomplete
disease
therapeutic
algorithms
are
far
from
optimal.
Immunologic
aberrations
considered
key
factors
for
along
vascular
excess
fibrosis.
Adaptive
immunity
its
specialized
responses
an
attractive
research
target
both
T
B
cells
have
been
extensively
studied
in
recent
years.
In
present
review,
focus
placed
on
SSc.
cell
homeostasis
deranged
subsets
exhibit
activated
phenotype
abnormal
receptor
signaling.
Autoantibodies
hallmark
perception
their
diagnostic
pathogenetic
role
analyzed.
addition,
cytokine
release
effect
fibrosis
examined,
together
tissue
infiltration
lung.
These
data
support
concept
targeting
as
part
plan
SSc
through
well
designed
clinical
trials.
Journal of Clinical Investigation,
Год журнала:
2022,
Номер
132(8)
Опубликована: Март 1, 2022
Collagens
in
the
extracellular
matrix
(ECM)
provide
a
physical
barrier
to
tumor
immune
infiltration,
while
also
acting
as
ligand
for
inhibitory
receptors.
Transforming
growth
factor-β
(TGF-β)
is
key
contributor
shaping
ECM
by
stimulating
production
and
remodeling
of
collagens.
TGF-β
activation
signatures
collagen-rich
environments
have
both
been
associated
with
T
cell
exclusion
lack
responses
immunotherapy.
Here,
we
describe
effect
targeting
collagens
that
signal
through
leukocyte-associated
immunoglobulin-like
receptor-1
(LAIR-1)
combination
blockade
programmed
death
1
(PD-L1).
This
approach
remodeled
collagenous
matrix,
enhanced
infiltration
CD8+
cells,
repolarized
suppressive
macrophage
populations,
resulting
high
cure
rates
long-term
tumor-specific
protection
across
murine
models
colon
mammary
carcinoma.
The
results
highlight
advantage
direct
components
checkpoint
therapy.
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
157, С. 113996 - 113996
Опубликована: Ноя. 15, 2022
A
Non-healing
infected
wound
is
an
ever-growing
global
epidemic,
with
increasing
burden
of
mortality
rates
and
management
costs.
The
problems
chronic
infections
their
outcomes
will
continue
as
long
underlying
causes
like
diabetic
wounds
grow
spread.
Commercial
therapies
employed
have
limited
potential
that
inhibits
pivotal
functions
tissue
re-epithelialization
properties
resulting
in
infections.
Nanomaterial
based
drug
delivery
formulations
involving
biological
macromolecules
are
developing
areas
interest
healing
applications
which
utilized
the
skin
cost-effective
preparations.
Research
conducted
on
nanofibers
has
shown
enhanced
establishment
improved
cell
proliferation
growth
bioactive
organic
molecules
at
site.
However,
targeted
anti-scarring
regeneration
aspects
not
been
updated
discussed
case
macromolecule
impregnated
nanofibrous
mats.
Hence,
this
review
focuses
brief
concepts
management,
therapeutic
commercialized
dressings
currently
available
field
care,
effective
electrospun
different
advancement
nanomaterials
for
engineering
discussed.
These
new
findings
pave
way
producing
high
scaffolds
delivery.
Biomedicines,
Год журнала:
2022,
Номер
10(5), С. 1206 - 1206
Опубликована: Май 23, 2022
Astrocytes
are
essential
for
normal
brain
development
and
functioning.
They
respond
to
injury
disease
through
a
process
referred
as
reactive
astrogliosis,
where
the
reactivity
is
highly
heterogenous
context-dependent.
Reactive
astrocytes
active
contributors
pathology
can
exert
beneficial,
detrimental,
or
mixed
effects
following
insults.
Transforming
growth
factor-β
(TGF-β)
has
been
identified
one
of
key
factors
regulating
astrocyte
reactivity.
The
genetic
pharmacological
manipulation
TGF-β
signaling
pathway
in
animal
models
central
nervous
system
(CNS)
alters
pathological
functional
outcomes.
This
review
aims
provide
recent
understanding
regarding
injury,
aging,
neurodegeneration.
Further,
it
explores
how
modulates
function
context
CNS
injury.
Biomolecules,
Год журнала:
2022,
Номер
12(5), С. 635 - 635
Опубликована: Апрель 25, 2022
Transforming
growth
factor
β
(TGF-β)
is
a
multifunctional
cytokine
regulating
homeostasis
and
immune
responses
in
adult
animals
humans.
Aberrant
overactive
TGF-β
signaling
promotes
cancer
initiation
fibrosis
through
epithelial-mesenchymal
transition
(EMT),
as
well
the
invasion
metastatic
of
cells.
key
that
active
during
hypoxic
conditions
thereby
capable
contributing
to
angiogenesis
various
types
cancer.
Another
potent
role
suppressing
patients.
The
strong
tumor-promoting
effects
its
profibrotic
make
it
focus
for
development
novel
therapeutic
strategies
against
an
attractive
drug
target
combination
with
regulatory
checkpoint
inhibitors.
belongs
family
cytokines
exert
their
function
via
serine/threonine
kinase
transmembrane
receptors
intracellular
Smad
proteins
canonical
pathway
co-regulators
such
adaptor
protein
E3
ubiquitin
ligases
TNF
receptor-associated
4
(TRAF4)
6
(TRAF6)
promote
non-canonical
pathways.
Finally,
outcome
gene
transcription
initiated
by
context-dependent
controlled
signals
exerted
other
factors
EGF
Wnt.
Here,
we
discuss
synergistic
cooperation
between
hypoxia
development,
