Rosacea, an infectious disease: why rosacea with papulopustules should be considered a demodicosis. A narrative review DOI
F.M.N. Forton

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2022, Volume and Issue: 36(7), P. 987 - 1002

Published: March 12, 2022

Rosacea and demodicosis are common facial conditions in dermatology practice. While is clearly the result of Demodex mite infestation, pathogenicity rosacea still not sufficiently explained, so that it defined by its symptoms, cause. It usually considered as a disease immune system associated with neurogenic inflammation triggered various factors (ultraviolet light, heat, spicy food, alcohol, stress microorganisms). Its links remain controversial, although there increasing evidence mites may play key role inflammatory process. Indeed, high densities observed nearly all cases papulopustules (PPR) can be effectively treated topical acaricidal agents. Recent studies suggest induces two opposite actions on host immunity: defensive response aimed at eliminating an immunosuppressive action favouring own proliferation. Moreover, initial likely diverted towards benefit for mite, via T-cell exhaustion induced properties vascular endothelial growth factor, which also explain favourable influence altered background seems to exert In this review, against causal discussed, applying three systems traditionally used attribute causality (modified Koch criteria, Hill criteria Rothman model). The findings PPR reasonably attributed proliferation, appears necessary factor centre network multiple co-factors interact occurrence severity from limited (pityriasis folliculorum) more marked (PPR). could, therefore, chronic infection exhaustion.

Language: Английский

Metabolic orchestration of the wound healing response DOI Creative Commons
Sabine A. Eming, Peter J. Murray, Edward J. Pearce

et al.

Cell Metabolism, Journal Year: 2021, Volume and Issue: 33(9), P. 1726 - 1743

Published: Aug. 11, 2021

Language: Английский

Citations

186
Mechanical regulation of chromatin and transcription DOI
Sirio Dupont, Sara A. Wickström

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 23(10), P. 624 - 643

Published: May 23, 2022

Language: Английский

Citations

143
Pathogenetic Aspects of Systemic Sclerosis: A View Through the Prism of B Cells DOI Creative Commons
Κωνσταντίνος Μελισσαρόπουλος,

George Iliopoulos,

Lazaros I. Sakkas

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: June 23, 2022

Systemic sclerosis (SSc) is a rare fibrotic rheumatic disease, associated with psychological distress and increased morbidity mortality due to skin involvement internal organ damage. The current understanding of the complex pathogenesis yet incomplete disease therapeutic algorithms are far from optimal. Immunologic aberrations considered key factors for along vascular excess fibrosis. Adaptive immunity its specialized responses an attractive research target both T B cells have been extensively studied in recent years. In present review, focus placed on SSc. cell homeostasis deranged subsets exhibit activated phenotype abnormal receptor signaling. Autoantibodies hallmark perception their diagnostic pathogenetic role analyzed. addition, cytokine release effect fibrosis examined, together tissue infiltration lung. These data support concept targeting as part plan SSc through well designed clinical trials.

Language: Английский

Citations

88
Remodeling the tumor microenvironment via blockade of LAIR-1 and TGF-β signaling enables PD-L1–mediated tumor eradication DOI Creative Commons

Lucas A. Horn,

Paul L. Chariou, Sofia R. Gameiro

et al.

Journal of Clinical Investigation, Journal Year: 2022, Volume and Issue: 132(8)

Published: March 1, 2022

Collagens in the extracellular matrix (ECM) provide a physical barrier to tumor immune infiltration, while also acting as ligand for inhibitory receptors. Transforming growth factor-β (TGF-β) is key contributor shaping ECM by stimulating production and remodeling of collagens. TGF-β activation signatures collagen-rich environments have both been associated with T cell exclusion lack responses immunotherapy. Here, we describe effect targeting collagens that signal through leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) combination blockade programmed death 1 (PD-L1). This approach remodeled collagenous matrix, enhanced infiltration CD8+ cells, repolarized suppressive macrophage populations, resulting high cure rates long-term tumor-specific protection across murine models colon mammary carcinoma. The results highlight advantage direct components checkpoint therapy.

Language: Английский

Citations

81
Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies DOI
Isabella Lurje, Nadine T. Gaisa, Ralf Weiskirchen

et al.

Molecular Aspects of Medicine, Journal Year: 2023, Volume and Issue: 92, P. 101191 - 101191

Published: May 24, 2023

Language: Английский

Citations

69
Therapeutic applications of electrospun nanofibers impregnated with various biological macromolecules for effective wound healing strategy – A review DOI Creative Commons

Lakshimipriya Sethuram,

Thomas John

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 157, P. 113996 - 113996

Published: Nov. 15, 2022

A Non-healing infected wound is an ever-growing global epidemic, with increasing burden of mortality rates and management costs. The problems chronic infections their outcomes will continue as long underlying causes like diabetic wounds grow spread. Commercial therapies employed have limited potential that inhibits pivotal functions tissue re-epithelialization properties resulting in infections. Nanomaterial based drug delivery formulations involving biological macromolecules are developing areas interest healing applications which utilized the skin cost-effective preparations. Research conducted on nanofibers has shown enhanced establishment improved cell proliferation growth bioactive organic molecules at site. However, targeted anti-scarring regeneration aspects not been updated discussed case macromolecule impregnated nanofibrous mats. Hence, this review focuses brief concepts management, therapeutic commercialized dressings currently available field care, effective electrospun different advancement nanomaterials for engineering discussed. These new findings pave way producing high scaffolds delivery.

Language: Английский

Citations

66
TGF-β as a Key Modulator of Astrocyte Reactivity: Disease Relevance and Therapeutic Implications DOI Creative Commons
Jian Luo

Biomedicines, Journal Year: 2022, Volume and Issue: 10(5), P. 1206 - 1206

Published: May 23, 2022

Astrocytes are essential for normal brain development and functioning. They respond to injury disease through a process referred as reactive astrogliosis, where the reactivity is highly heterogenous context-dependent. Reactive astrocytes active contributors pathology can exert beneficial, detrimental, or mixed effects following insults. Transforming growth factor-β (TGF-β) has been identified one of key factors regulating astrocyte reactivity. The genetic pharmacological manipulation TGF-β signaling pathway in animal models central nervous system (CNS) alters pathological functional outcomes. This review aims provide recent understanding regarding injury, aging, neurodegeneration. Further, it explores how modulates function context CNS injury.

Language: Английский

Citations

61
Immune cell dysregulation as a mediator of fibrosis in systemic sclerosis DOI
Dan Fang, Beidi Chen,

Alain Lescoat

et al.

Nature Reviews Rheumatology, Journal Year: 2022, Volume and Issue: 18(12), P. 683 - 693

Published: Nov. 9, 2022

Language: Английский

Citations

53
The Synergistic Cooperation between TGF-β and Hypoxia in Cancer and Fibrosis DOI Creative Commons
Pramod Mallikarjuna, Yang Zhou, Maréne Landström

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(5), P. 635 - 635

Published: April 25, 2022

Transforming growth factor β (TGF-β) is a multifunctional cytokine regulating homeostasis and immune responses in adult animals humans. Aberrant overactive TGF-β signaling promotes cancer initiation fibrosis through epithelial-mesenchymal transition (EMT), as well the invasion metastatic of cells. key that active during hypoxic conditions thereby capable contributing to angiogenesis various types cancer. Another potent role suppressing patients. The strong tumor-promoting effects its profibrotic make it focus for development novel therapeutic strategies against an attractive drug target combination with regulatory checkpoint inhibitors. belongs family cytokines exert their function via serine/threonine kinase transmembrane receptors intracellular Smad proteins canonical pathway co-regulators such adaptor protein E3 ubiquitin ligases TNF receptor-associated 4 (TRAF4) 6 (TRAF6) promote non-canonical pathways. Finally, outcome gene transcription initiated by context-dependent controlled signals exerted other factors EGF Wnt. Here, we discuss synergistic cooperation between hypoxia development,

Language: Английский

Citations

44
Tissue‐resident memory T cells and lung immunopathology DOI Creative Commons
In Su Cheon, Young Min Son, Jie Sun

et al.

Immunological Reviews, Journal Year: 2023, Volume and Issue: 316(1), P. 63 - 83

Published: April 4, 2023

Rapid reaction to microbes invading mucosal tissues is key protect the host against disease. Respiratory tissue-resident memory T (T

Language: Английский

Citations

35