Journal of the European Academy of Dermatology and Venereology,
Год журнала:
2022,
Номер
36(7), С. 987 - 1002
Опубликована: Март 12, 2022
Rosacea
and
demodicosis
are
common
facial
conditions
in
dermatology
practice.
While
is
clearly
the
result
of
Demodex
mite
infestation,
pathogenicity
rosacea
still
not
sufficiently
explained,
so
that
it
defined
by
its
symptoms,
cause.
It
usually
considered
as
a
disease
immune
system
associated
with
neurogenic
inflammation
triggered
various
factors
(ultraviolet
light,
heat,
spicy
food,
alcohol,
stress
microorganisms).
Its
links
remain
controversial,
although
there
increasing
evidence
mites
may
play
key
role
inflammatory
process.
Indeed,
high
densities
observed
nearly
all
cases
papulopustules
(PPR)
can
be
effectively
treated
topical
acaricidal
agents.
Recent
studies
suggest
induces
two
opposite
actions
on
host
immunity:
defensive
response
aimed
at
eliminating
an
immunosuppressive
action
favouring
own
proliferation.
Moreover,
initial
likely
diverted
towards
benefit
for
mite,
via
T-cell
exhaustion
induced
properties
vascular
endothelial
growth
factor,
which
also
explain
favourable
influence
altered
background
seems
to
exert
In
this
review,
against
causal
discussed,
applying
three
systems
traditionally
used
attribute
causality
(modified
Koch
criteria,
Hill
criteria
Rothman
model).
The
findings
PPR
reasonably
attributed
proliferation,
appears
necessary
factor
centre
network
multiple
co-factors
interact
occurrence
severity
from
limited
(pityriasis
folliculorum)
more
marked
(PPR).
could,
therefore,
chronic
infection
exhaustion.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 927 - 927
Опубликована: Янв. 11, 2024
Eosinophilic
esophagitis
(EoE)
is
a
chronic,
progressive,
type
2
inflammatory
disease
with
increasing
global
prevalence.
An
eosinophil-predominant
inflammation
that
permeates
the
epithelium
and
deeper
esophageal
layers
characterizes
disease.
Several
cytokines,
mainly
derived
from
T-helper
(Th2)
cells
epithelial
cells,
are
involved
in
perpetuating
responses
by
surface
permeability
promoting
tissue
remodeling
characterized
epithelial–mesenchymal
transition
(EMT)
collagen
deposition.
This
leads
to
strictures
narrow
caliber
esophagi,
which
proportional
patient’s
age
untreated
length.
Pathophysiological
mechanisms
leading
EoE
have
been
described
recent
years,
transforming
growth
factor
beta
(TGF)-beta
fibrotic
phenomena
EoE.
However,
evidence
on
dependence
of
these
TGF-beta
scarce
contradictory.
review
provides
state-of-the
art
knowledge
intimate
fibrosis
its
clinical
consequences.
Clinical and Translational Medicine,
Год журнала:
2024,
Номер
14(1)
Опубликована: Янв. 1, 2024
Abstract
Background
Radiotherapy
is
the
main
treatment
modality
for
thoracic
tumours,
but
it
may
induce
pulmonary
fibrosis.
Currently,
pathogenesis
of
radiation‐induced
fibrosis
(RIPF)
unclear,
and
effective
treatments
are
lacking.
Transforming
growth
factor
beta
1
(TGFβ1)
plays
a
central
role
in
RIPF.
We
found
that
activated
TGFβ1
had
better
performance
radiation
pneumonitis
(RP)
risk
prediction
by
detecting
total
levels
patient
serum.
αv
integrin
key
roles
activation,
integrin‐mediated
activation
RIPF
unclear.
Here,
we
investigated
application
antagonist
cilengitide
to
prevent
Methods
Itgav
loxP/loxP
;Pdgfrb‐Cre
mice
were
generated
conditionally
knocking
out
myofibroblasts,
wild‐type
treated
with
or
placebo.
All
received
16
Gy
underwent
sham
procedure.
Lung
was
measured
modified
Ashcroft
score
microcomputed
tomography
(CT).
An
enzyme‐linked
immunosorbent
assay
(ELISA)
used
measure
serum
concentration,
Smad2/3
p‐Smad2/3
determined
via
Western
blotting.
Results
Conditional
knockout
significantly
attenuated
(
p
<
.01).
Hounsfield
units
(HUs)
lungs
reduced
compared
control
.001).
decreased
active
secretion
inhibited
fibroblast
expression.
Exogenous
TGFβ1,
not
latent
reversed
these
reductions.
Furthermore,
elicited
similar
results
prevented
Conclusions
The
present
study
revealed
conditional
both
inhibiting
activation.
Highlights
Activated
has
superior
capacity
predicting
vital
development
(RIPF).
knock
myofibroblasts
from
developing
Cilengitide
alleviated
be
targeted
approaches
preventing
Science Signaling,
Год журнала:
2024,
Номер
17(844)
Опубликована: Июль 9, 2024
Inhibitors
of
the
transforming
growth
factor-β
(TGF-β)
pathway
are
potentially
promising
antifibrotic
therapies,
but
nonselective
simultaneous
inhibition
all
three
TGF-β
homologs
has
safety
liabilities.
TGF-β1
is
noncovalently
bound
to
a
latency-associated
peptide
that
is,
in
turn,
covalently
different
presenting
molecules
within
large
latent
complexes.
The
TGF-β-binding
proteins
(LTBPs)
present
extracellular
matrix,
and
presented
on
immune
cells
by
two
transmembrane
proteins,
glycoprotein
A
repetitions
predominant
(GARP)
leucine-rich
repeat
protein
33
(LRRC33).
Here,
we
describe
LTBP-49247,
an
antibody
selectively
inhibited
activation
LTBPs
did
not
bind
GARP
or
LRRC33.
Structural
studies
demonstrated
LTBP-49247
recognized
epitope
LTBP-presented
accessible
GARP-
LRRC33-presented
TGF-β1,
explaining
antibody's
selectivity
for
LTBP-complexed
TGF-β1.
In
rodent
models
kidney
fibrosis
etiologies,
attenuated
fibrotic
progression,
indicating
central
role
renal
fibrosis.
mice,
have
toxic
effects
associated
with
less
selective
inhibitors.
These
results
establish
feasibility
targeting
LTBP-bound
as
approach
treating
Journal of the European Academy of Dermatology and Venereology,
Год журнала:
2022,
Номер
36(7), С. 987 - 1002
Опубликована: Март 12, 2022
Rosacea
and
demodicosis
are
common
facial
conditions
in
dermatology
practice.
While
is
clearly
the
result
of
Demodex
mite
infestation,
pathogenicity
rosacea
still
not
sufficiently
explained,
so
that
it
defined
by
its
symptoms,
cause.
It
usually
considered
as
a
disease
immune
system
associated
with
neurogenic
inflammation
triggered
various
factors
(ultraviolet
light,
heat,
spicy
food,
alcohol,
stress
microorganisms).
Its
links
remain
controversial,
although
there
increasing
evidence
mites
may
play
key
role
inflammatory
process.
Indeed,
high
densities
observed
nearly
all
cases
papulopustules
(PPR)
can
be
effectively
treated
topical
acaricidal
agents.
Recent
studies
suggest
induces
two
opposite
actions
on
host
immunity:
defensive
response
aimed
at
eliminating
an
immunosuppressive
action
favouring
own
proliferation.
Moreover,
initial
likely
diverted
towards
benefit
for
mite,
via
T-cell
exhaustion
induced
properties
vascular
endothelial
growth
factor,
which
also
explain
favourable
influence
altered
background
seems
to
exert
In
this
review,
against
causal
discussed,
applying
three
systems
traditionally
used
attribute
causality
(modified
Koch
criteria,
Hill
criteria
Rothman
model).
The
findings
PPR
reasonably
attributed
proliferation,
appears
necessary
factor
centre
network
multiple
co-factors
interact
occurrence
severity
from
limited
(pityriasis
folliculorum)
more
marked
(PPR).
could,
therefore,
chronic
infection
exhaustion.
