Genetic regulation and manipulation of nicotine biosynthesis in tobacco: strategies to eliminate addictive alkaloids
Journal of Experimental Botany,
Год журнала:
2023,
Номер
75(6), С. 1741 - 1753
Опубликована: Авг. 30, 2023
Abstract
Tobacco
(Nicotiana
tabacum
L.)
is
a
widely
cultivated
crop
of
the
genus
Nicotiana.
Due
to
highly
addictive
nature
tobacco
products,
smoking
remains
leading
cause
preventable
death
and
disease.
There
therefore
critical
need
develop
varieties
with
reduced
or
non-addictive
nicotine
levels.
Nicotine
related
pyridine
alkaloids
biosynthesized
in
roots
plants
are
transported
leaves,
where
they
stored
vacuoles
as
defense
against
predators.
Jasmonate,
defense-related
plant
hormone,
plays
crucial
signaling
role
activating
transcriptional
regulators
that
coordinate
expression
downstream
metabolic
transport
genes
involved
production.
In
recent
years,
substantial
progress
has
been
made
molecular
genomics
research,
revealing
many
regulatory
biosynthesis.
These
advances
have
enabled
us
low
ultra-low
levels
through
various
methodologies,
such
mutational
breeding,
genetic
engineering,
genome
editing.
We
review
on
manipulation
production
tobacco,
which
serves
an
excellent
example
engineering
profound
social
implications.
Язык: Английский
Adaptable Alchemy: Exploring the Flexibility of Specialized Metabolites to Environmental Perturbations Through Post-Translational Modifications (PTMs)
Plants,
Год журнала:
2025,
Номер
14(3), С. 489 - 489
Опубликована: Фев. 6, 2025
Plants
are
subjected
to
various
stresses
during
the
growth
process,
including
biotic
stresses,
as
well
abiotic
such
temperature,
drought,
salt,
and
heavy
metals.
To
cope
with
these
adversities,
plants
have
evolved
complex
regulatory
mechanisms
their
long-term
environmental
adaptations.
In
a
suddenly
changing
environment,
protein
modifiers
target
other
proteins
induce
post-translational
modification
(PTM)
in
order
maintain
cell
homeostasis
biological
activity
plants.
PTMs
modulate
of
enzymes
transcription
factors
respective
metabolic
pathways,
enabling
produce
essential
compounds
for
survival
under
stress
conditions.
Examples
include
phosphorylation,
ubiquitination,
glycosylation,
acetylation,
protein–protein
interactions,
targeted
degradation.
Furthermore,
role
histone
modifications
regulating
secondary
metabolism
deserves
attention
due
its
potential
impact
on
heritability
contribution
tolerance.
Understanding
epigenetic
aspect
can
provide
valuable
insights
into
underlying
response.
this
context,
also
examining
that
biosynthesis
metabolites
is
meaningful.
Secondary
encompass
wide
range
flavonoids,
alkaloids,
terpenoids.
These
play
crucial
plant
defense
against
herbivores,
pathogens,
oxidative
stress.
it
imperative
understand
tolerance
how
understanding
be
leveraged
improve
survival.
While
many
studies
focused
transcriptional
regulation
metabolites,
there
growing
interest
changes
PTMs,
able
plants’
response
conclusion,
comprehensive
exploration
enhance
our
responses
This
knowledge
holds
promise
future
applications
genetic
improvement
breeding
strategies
aimed
at
increasing
resilience
challenges.
Язык: Английский
Revolutionizing Speciality teas: Multi-omics prospective to breed anthocyanin-rich tea
Food Research International,
Год журнала:
2025,
Номер
unknown, С. 116312 - 116312
Опубликована: Март 1, 2025
Язык: Английский
Production, Utilization, and Breeding of Winter Rye
Опубликована: Янв. 1, 2025
Язык: Английский
Plant biochemical genetics in the multiomics era
Journal of Experimental Botany,
Год журнала:
2023,
Номер
74(15), С. 4293 - 4307
Опубликована: Май 12, 2023
Our
understanding
of
plant
biology
has
been
revolutionized
by
modern
genetics
and
biochemistry.
However,
biochemical
can
be
traced
back
to
the
foundation
Mendelian
genetics;
indeed,
one
Mendel's
milestone
discoveries
seven
characteristics
pea
plants
later
came
ascribed
a
mutation
in
starch
branching
enzyme.
Here,
we
review
both
current
historical
strategies
for
elucidation
metabolic
pathways
genes
that
encode
their
component
enzymes
regulators.
We
use
this
discuss
range
classical
genetic
phenomena
including
epistasis,
canalization,
heterosis
as
viewed
through
lens
contemporary
high-throughput
data
obtained
via
array
approaches
currently
adopted
multiomics
studies.
Язык: Английский
How metabolism and development are intertwined in space and time
The Plant Journal,
Год журнала:
2023,
Номер
116(2), С. 347 - 359
Опубликована: Июль 12, 2023
Developmental
transitions,
occurring
throughout
the
life
cycle
of
plants,
require
precise
regulation
metabolic
processes
to
generate
energy
and
resources
necessary
for
committed
growth
processes.
In
parallel,
establishment
new
cells,
tissues,
even
organs,
alongside
their
differentiation
provoke
profound
changes
in
metabolism.
It
is
increasingly
being
recognized
that
there
a
certain
degree
feedback
between
components
products
pathways
developmental
regulators.
The
generation
large-scale
metabolomics
datasets
during
combination
with
molecular
genetic
approaches
has
helped
further
our
knowledge
on
functional
importance
development.
this
perspective
article,
we
provide
insights
into
studies
elucidate
interactions
metabolism
development
at
temporal
spatial
scales.
We
additionally
discuss
how
influences
cell
growth-related
also
highlight
intermediates
function
as
signaling
molecules
direct
plant
response
changing
internal
external
conditions.
Язык: Английский