Recent advances in photopharmacology: Harnessing visible light‐activated azobenzene photoswitches DOI Creative Commons

Yongliang Feng,

Kun Zhang,

Xingrui Gao

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract In the era of precision medicine, photopharmacology that employs molecular photoswitches offers unique opportunities to control action bioactive molecules with high spatiotemporal resolution, while reducing drug side effects, systemic toxicity and emergence resistance. Over past two decades, field has witnessed great achievements in treating blindness, cancer, diabetes, antibiotic resistance, name but a few. Several challenges remain, however, particular fact most photopharmacological agents trigger their activity by Ultraviolet light, which is damaging normal cells poor tissue permeability. Visible light‐activated are hence highly desirable have captured keen recent research interest. This review highlights strategies for synthesis visible light‐responsive azobenzenes (ABs) applications emerging photopharmacology. Such photoswitchable drugs tremendously extend scope future vivo applications. Furthermore, we identify current discuss rational design switches at higher wavelength. We hope inspire further into photochemistry novel based on ABs or other photoswitches, triggered excitation light “phototherapeutic window” 650–900 nm, ultimately enabling full realization these “smart” clinical practice.

Language: Английский

Capsaicin from chili peppers and its analogues and their valued applications: An updated literature review DOI
Na Wang, Xiang Zhou,

Taihong Zhang

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 208, P. 116034 - 116034

Published: Feb. 25, 2025

Language: Английский

Citations

1
Discovery of novel seven-membered ring derivatives of ONC212 as caseinolytic protease P protein activators using the ring expansion strategy: Rational design, synthesis, and antibacterial evaluation DOI

X. FU,

Yu Peng,

Zhou‐Qing Long

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141866 - 141866

Published: March 1, 2025

Language: Английский

Citations

0
DSF‐inspired discovery of novel zingerone‐based quorum‐sensing inhibitors: an attractive tactic of fighting Xanthomonas bacterial infections DOI Open Access
Hong Liang,

Yu‐Mei Feng,

Dan Zeng

et al.

Pest Management Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Plant bacterial diseases have precipitated a global crisis in human health and food security. In agriculture, such as the rice white-leaf blight can cause considerable reduction crop yields and, extreme cases, complete failure. Therefore, there is an urgent need for novel green pesticides with innovative modes-of-action (MoAs). A series of zingerone derivatives isopropanolamine skeleton were designed their quorum-sensing effects estimated using biomimetic strategies. The results showed that compound A12 effectively inhibits growth Xanthomonas oryzae pv. [Xoo, median effective concentration (EC50) = 3.55 μg mL-1], axonopodis citri (Xac, EC50 3.23 mL-1) oryzicola (Xoc, 7.48 mL-1). Molecular docking revealed forms multiple interactions RpfF protein, while fluorescence titration experiments further verified interaction between them. Additionally, was found to inhibit Xoo biofilm formation, extracellular polysaccharide production other virulence factors. vivo pot exhibited excellent curative (53.59%) protective (57.65%) activity against Xoo. conclusion, A12's primary MoA achieved by affecting formation biofilms expression various factors, including related genes. summary, this study highlights displays notable sensing activity. advancement inhibitors through strategies offers promising avenues future research. © 2025 Society Chemical Industry.

Language: Английский

Citations

0
Polystyrene-microplastics and Emamectin Benzoate co-exposure induced lipid remodeling by suppressing PPARα signals to drive ACSL4-dependent ferroptosis and carp splenic injury DOI
Hao Wu,

Tong Xu,

Naixi Yang

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2025, Volume and Issue: unknown, P. 106396 - 106396

Published: March 1, 2025

Language: Английский

Citations

0
Discovery of new 1,2,3,4-tetrahydro-β-carboline derivatives decorated with 3-N-substituted propionyl moiety flexibly bridged-chain as reactive oxygen species inducer for efficient antibacterial treatment DOI
Yike Yang, Shanshan Su,

Zhaoju Sun

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 160, P. 108473 - 108473

Published: April 14, 2025

Language: Английский

Citations

0
Recent advances in photopharmacology: Harnessing visible light‐activated azobenzene photoswitches DOI Creative Commons

Yongliang Feng,

Kun Zhang,

Xingrui Gao

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract In the era of precision medicine, photopharmacology that employs molecular photoswitches offers unique opportunities to control action bioactive molecules with high spatiotemporal resolution, while reducing drug side effects, systemic toxicity and emergence resistance. Over past two decades, field has witnessed great achievements in treating blindness, cancer, diabetes, antibiotic resistance, name but a few. Several challenges remain, however, particular fact most photopharmacological agents trigger their activity by Ultraviolet light, which is damaging normal cells poor tissue permeability. Visible light‐activated are hence highly desirable have captured keen recent research interest. This review highlights strategies for synthesis visible light‐responsive azobenzenes (ABs) applications emerging photopharmacology. Such photoswitchable drugs tremendously extend scope future vivo applications. Furthermore, we identify current discuss rational design switches at higher wavelength. We hope inspire further into photochemistry novel based on ABs or other photoswitches, triggered excitation light “phototherapeutic window” 650–900 nm, ultimately enabling full realization these “smart” clinical practice.

Language: Английский

Citations

0