2024 FDA TIDES (Peptides and Oligonucleotides) Harvest
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 291 - 291
Опубликована: Фев. 20, 2025
In
2024,
the
FDA
approved
fifty
novel
drugs,
including
four
peptides
and
oligonucleotides
(TIDEs)
(two
pepTIDEs
two
oligonucleoTIDEs),
highlighting
their
increasing
importance
as
effective
alternatives
to
traditional
drug
classes.
TIDEs
provide
essential
therapies
for
complex
diseases,
such
genetic
disorders,
rather
than
merely
addressing
symptoms.
addition
oligonucleotide
therapeutics
various
conditions,
became
first
treatment
Rett
Syndrome
in
2023
were
also
used
treat
Niemann–Pick
disease
type
C
(NPC)
2024.
Interestingly,
among
strategies
employed
recent
approvals
enhance
stability
and/or
delivery,
prodrug
approach,
exemplified
by
palopegteriparatide
pegulicianine,
is
emerging
a
more
targeted
precise
therapeutic
strategy.
Additionally,
Enhanced
Stabilization
Chemistry
(ESC)-GalNAc
platform
has
been
expanded
hepatic
delivery
of
new
drug,
olezarsen.
Furthermore,
modifications
ribose
moiety
oligonucleotides,
3′-amino
substitution
imetelstat,
stability.
This
review
examines
TIDES
2024
based
on
chemical
structure,
medical
targets,
modes
action,
administration
routes,
common
adverse
effects.
addition,
it
highlights
how
strategy
improved
targeting
efficiency
extended
half-lives
active
drugs.
Язык: Английский
Advances in Therapeutic Peptides Separation and Purification
Separations,
Год журнала:
2024,
Номер
11(8), С. 233 - 233
Опубликована: Июль 29, 2024
Peptides
are
gaining
prominence
in
various
fields,
including
the
pharmaceutical
industry.
To
meet
regulatory
requirements,
they
must
achieve
a
certain
purity
threshold
to
ensure
safe
administration.
Numerous
purification
technologies
have
been
employed
purify
peptides,
aiming
reduce
cost
and
time
while
being
sustainable
efficient.
These
include
chromatography,
magnetic
nanoparticles,
isoelectric
focusing,
membrane
filtration.
The
physicochemical
properties
of
peptides
main
driving
element
behind
these
technologies.
While
chromatographic
separation
remains
gold
standard
for
peptide
purification,
with
models
predict
elution
behaviors
other
demonstrated
their
capability
performance
established
methodologies,
better
productivity
reduced
cost.
This
opens
door
further
investigational
studies
assess
outcomes
potentially
introduce
new
techniques
purification.
In
this
review,
we
examine
terms
efficiency
ability
sustainability
concluding
remarks
an
outlook
on
future
advancements.
Язык: Английский
Lasso Peptides Realm: Insights and Applications
Peptides,
Год журнала:
2024,
Номер
182, С. 171317 - 171317
Опубликована: Ноя. 1, 2024
Язык: Английский
A New Green Oxyma-Sulfonate Coupling Reagent for Sustainable Organic Transformations
ACS Sustainable Chemistry & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
Язык: Английский
Therapeutic peptides and their delivery using lipid-based nanoparticles
Tzu Chi Medical Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 2, 2025
A
BSTRACT
Therapeutic
peptides
have
become
an
intensively
anticipated
research
field
for
novel
drug
discovery
and
design
owing
to
their
high
specificity,
efficacy,
biocompatibility.
The
advances
in
computer
technology
structural
biology,
together
with
the
invention
of
chemical
peptide
synthesis
methods,
led
tremendous
progress
this
field.
Over
years,
more
than
100
peptide-based
therapeutics
been
approved
clinical
use,
many
others
are
currently
under
trials.
However,
vivo
application
therapeutic
is
hindered
by
intrinsic
disadvantages
peptides,
such
as
poor
stability
against
enzymatic
degradations,
short
half-life,
low
oral
bioavailability.
Therefore,
strategies
efficiently
protecting
inside
body
facilitating
delivery
targets
required.
Lipid-based
nanoparticles
considered
a
versatile
class
carriers
delivery.
Their
biocompatibility,
biodegradability,
ability
interact
biological
membranes
make
them
ideal
platforms
peptides.
Here,
leveraging
examples,
we
aim
provide
comprehensive
review
current
status
developments
lipid-based
carriers.
Recent
attempts
utilize
also
discussed.
Язык: Английский
“Actual” peptide properties required for nanoparticle development in precision cancer therapeutic delivery
Journal of Controlled Release,
Год журнала:
2025,
Номер
unknown, С. 113866 - 113866
Опубликована: Май 1, 2025
Язык: Английский
Elastin-Derived Peptide-Based Hydrogels as a Potential Drug Delivery System
Gels,
Год журнала:
2024,
Номер
10(8), С. 531 - 531
Опубликована: Авг. 12, 2024
A
peptide-based
hydrogel
sequence
was
computationally
predicted
from
the
Ala-rich
cross-linked
domains
of
elastin.
Three
candidate
peptides
were
subsequently
synthesised
and
characterised
as
potential
drug
delivery
vehicles.
The
elastin-derived
are
Fmoc-FFAAAAKAA-NH2,
Fmoc-FFAAAKAA-NH2,
Fmoc-FFAAAKAAA-NH2.
All
three
peptide
sequences
able
to
self-assemble
into
nanofibers.
However,
only
first
two
could
form
hydrogels,
which
preferred
systems
compared
solutions.
Both
these
also
exhibited
favourable
nanofiber
lengths
at
least
1.86
4.57
µm,
respectively,
beneficial
for
successful
stability
drugs.
shorter
fibre
third
(maximum
0.649
µm)
have
inhibited
their
self-assembly
three-dimensional
networks
crucial
formation.
Язык: Английский