Elastin-Derived Peptide-Based Hydrogels as a Potential Drug Delivery System DOI Creative Commons
Othman Al Musaimi, Keng Wooi Ng, Varshitha Gavva

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(8), P. 531 - 531

Published: Aug. 12, 2024

A peptide-based hydrogel sequence was computationally predicted from the Ala-rich cross-linked domains of elastin. Three candidate peptides were subsequently synthesised and characterised as potential drug delivery vehicles. The elastin-derived are Fmoc-FFAAAAKAA-NH2, Fmoc-FFAAAKAA-NH2, Fmoc-FFAAAKAAA-NH2. All three peptide sequences able to self-assemble into nanofibers. However, only first two could form hydrogels, which preferred systems compared solutions. Both these also exhibited favourable nanofiber lengths at least 1.86 4.57 µm, respectively, beneficial for successful stability drugs. shorter fibre third (maximum 0.649 µm) have inhibited their self-assembly three-dimensional networks crucial formation.

Language: Английский

2024 FDA TIDES (Peptides and Oligonucleotides) Harvest DOI Creative Commons
Othman Al Musaimi, Danah AlShaer, Beatriz G. de la Torre

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 291 - 291

Published: Feb. 20, 2025

In 2024, the FDA approved fifty novel drugs, including four peptides and oligonucleotides (TIDEs) (two pepTIDEs two oligonucleoTIDEs), highlighting their increasing importance as effective alternatives to traditional drug classes. TIDEs provide essential therapies for complex diseases, such genetic disorders, rather than merely addressing symptoms. addition oligonucleotide therapeutics various conditions, became first treatment Rett Syndrome in 2023 were also used treat Niemann–Pick disease type C (NPC) 2024. Interestingly, among strategies employed recent approvals enhance stability and/or delivery, prodrug approach, exemplified by palopegteriparatide pegulicianine, is emerging a more targeted precise therapeutic strategy. Additionally, Enhanced Stabilization Chemistry (ESC)-GalNAc platform has been expanded hepatic delivery of new drug, olezarsen. Furthermore, modifications ribose moiety oligonucleotides, 3′-amino substitution imetelstat, stability. This review examines TIDES 2024 based on chemical structure, medical targets, modes action, administration routes, common adverse effects. addition, it highlights how strategy improved targeting efficiency extended half-lives active drugs.

Language: Английский

Citations

2
Advances in Therapeutic Peptides Separation and Purification DOI Creative Commons
Othman Al Musaimi, Da’san M. M. Jaradat

Separations, Journal Year: 2024, Volume and Issue: 11(8), P. 233 - 233

Published: July 29, 2024

Peptides are gaining prominence in various fields, including the pharmaceutical industry. To meet regulatory requirements, they must achieve a certain purity threshold to ensure safe administration. Numerous purification technologies have been employed purify peptides, aiming reduce cost and time while being sustainable efficient. These include chromatography, magnetic nanoparticles, isoelectric focusing, membrane filtration. The physicochemical properties of peptides main driving element behind these technologies. While chromatographic separation remains gold standard for peptide purification, with models predict elution behaviors other demonstrated their capability performance established methodologies, better productivity reduced cost. This opens door further investigational studies assess outcomes potentially introduce new techniques purification. In this review, we examine terms efficiency ability sustainability concluding remarks an outlook on future advancements.

Language: Английский

Citations

6
Therapeutic peptides and their delivery using lipid-based nanoparticles DOI Creative Commons
Jui-Hung Yen,

Chun-Chun Chang,

Tien‐Yuan Wu

et al.

Tzu Chi Medical Journal, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

A BSTRACT Therapeutic peptides have become an intensively anticipated research field for novel drug discovery and design owing to their high specificity, efficacy, biocompatibility. The advances in computer technology structural biology, together with the invention of chemical peptide synthesis methods, led tremendous progress this field. Over years, more than 100 peptide-based therapeutics been approved clinical use, many others are currently under trials. However, vivo application therapeutic is hindered by intrinsic disadvantages peptides, such as poor stability against enzymatic degradations, short half-life, low oral bioavailability. Therefore, strategies efficiently protecting inside body facilitating delivery targets required. Lipid-based nanoparticles considered a versatile class carriers delivery. Their biocompatibility, biodegradability, ability interact biological membranes make them ideal platforms peptides. Here, leveraging examples, we aim provide comprehensive review current status developments lipid-based carriers. Recent attempts utilize also discussed.

Language: Английский

Citations

0
A New Green Oxyma-Sulfonate Coupling Reagent for Sustainable Organic Transformations DOI
Sayanta Roy, Bhubaneswar Mandal

ACS Sustainable Chemistry & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

Citations

0
Lasso Peptides Realm: Insights and Applications DOI Creative Commons
Othman Al Musaimi

Peptides, Journal Year: 2024, Volume and Issue: 182, P. 171317 - 171317

Published: Nov. 1, 2024

Language: Английский

Citations

2
Elastin-Derived Peptide-Based Hydrogels as a Potential Drug Delivery System DOI Creative Commons
Othman Al Musaimi, Keng Wooi Ng, Varshitha Gavva

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(8), P. 531 - 531

Published: Aug. 12, 2024

A peptide-based hydrogel sequence was computationally predicted from the Ala-rich cross-linked domains of elastin. Three candidate peptides were subsequently synthesised and characterised as potential drug delivery vehicles. The elastin-derived are Fmoc-FFAAAAKAA-NH2, Fmoc-FFAAAKAA-NH2, Fmoc-FFAAAKAAA-NH2. All three peptide sequences able to self-assemble into nanofibers. However, only first two could form hydrogels, which preferred systems compared solutions. Both these also exhibited favourable nanofiber lengths at least 1.86 4.57 µm, respectively, beneficial for successful stability drugs. shorter fibre third (maximum 0.649 µm) have inhibited their self-assembly three-dimensional networks crucial formation.

Language: Английский

Citations

1