A state-of-art of underlying molecular mechanisms and pharmacological interventions/nanotherapeutics for cisplatin resistance in gastric cancer

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 166, С. 115337 - 115337

Опубликована: Сен. 4, 2023

The fourth common reason of death among patients is gastric cancer (GC) and it a dominant tumor type in Ease Asia. One the problems GC therapy chemoresistance. Cisplatin (CP) platinum compound that causes DNA damage reducing progression viability cells. However, due to hyperactivation drug efflux pumps, dysregulation genes interactions microenvironment, cells can develop resistance CP chemotherapy. current review focuses on emergence with emphasizing molecular pathways, pharmacological compounds for reversing chemoresistance role nanostructures. Changes cell mechanisms such as upregulation pro-survival autophagy prevent CP-mediated apoptosis results resistance. Moreover, increase metastasis via EMT induction induces Dysregulation pathways PTEN, PI3K/Akt, Nrf2 others result changes response Non-coding RNAs determine application activity distinct sensitivity Due efficacy exosomes transferring bioactive molecules RNA cells, also newest progresses overcoming nanoplatforms delivery they accumulation at site by suppressing carcinogenic factors biological barriers, toxicity

Язык: Английский

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Preparation, characterization, and Co-delivery of cisplatin and doxorubicin-loaded liposomes to enhance anticancer Activities

Heliyon, Год журнала: 2023, Номер 9(10), С. e20657 - e20657

Опубликована: Окт. 1, 2023

Ovarian cancer stands as a leading cause of cancer-related deaths among women globally. This malignancy has hindered successful treatment attempts due to its inherent resistance chemotherapy agents. The utilization cisplatin and doxorubicin-loaded liposomes emerges strategically advantageous approach in the realm biomedical applications. strategy holds promise for augmenting drug efficacy, mitigating toxicity, refining pharmacokinetics, facilitating versatile delivery while accommodating combination therapies. In pursuit scholarly investigations, eminent databases, including PubMed/MEDLINE, ScienceDirect, Scopus, Google Scholar, were meticulously scrutinized. Within this study, nano-liposomal formulation was designed serve co-delivery system. system optimized by varying lipid concentrations, hydration time, DSPC: cholesterol molar ratios efficiently encapsulate load doxorubicin (DOX) (CIS) overcome problems. Lipo (CIS + DOX) underwent rigorous characterization dimensions, entrapment efficiencies release kinetics. Notably, efficiency loaded liposomal nanoparticles an impressive 85.29 ± 1.45 % 73.62 1.70 %, respectively. Furthermore, kinetics exhibited pH-dependent properties, with lower rates at physiological pH (7.4) than acidic (pH 5.4). Subsequent cytotoxicity assays revealed enhanced biocompatibility dual-drug HFF cells compared free combinations. Impressively, CIS DOX-loaded induced significant against A2780 comparison drugs combinatorial drugs. liposome showed apoptotic potential cell cycle arrest CIS, DOX, their DOX). Combining DOX via introduces promising therapeutic avenue addressing ovarian cancer. These nano-scale carriers hold attenuating untoward effects singular attendant toxicities.

Язык: Английский

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Evaluation of the protective effect of curcumin nanoparticles on lung cells (Beas-2B) treated with paclitaxel nanoparticles: targeting oxidative stress

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106657 - 106657

Опубликована: Янв. 1, 2025

Язык: Английский

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Development and Optimization of Curcumin-Loaded Citric Acid Functionalized Multi-Walled Carbon Nanotubes for Enhanced Breast Cancer Treatment Using Design of Experiment

Journal of Pharmaceutical Innovation, Год журнала: 2025, Номер 20(2)

Опубликована: Фев. 28, 2025

Язык: Английский

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Managing the unmanageable: The role of integrated-pathy in chronic disease

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 149 - 184

Опубликована: Янв. 1, 2025

Язык: Английский

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