Medical Oncology, Год журнала: 2025, Номер 42(5)
Опубликована: Апрель 23, 2025
Язык: Английский
Процитировано
1Development of Injectable Thermosensitive Nanocomposite Hydrogel for Ratiometric Drug Delivery to Treat Drug Resistant Chondrosarcoma In Vivo
Small, Год журнала: 2024, Номер 20(31)
Опубликована: Март 8, 2024
Abstract Chondrosarcoma(CS), a prevalent primary malignant bone tumor, frequently exhibits chemotherapy resistance attributed to upregulated anti‐apoptosis pathways such as the Bcl‐2 family. In this manuscript, new strategy is presented augment chemosensitivity and mitigate systemic toxicity by harnessing nano‐enabled drug delivery hydrogel platform. The platform utilizes “PLGA‐PEG‐PLGA”, an amphiphilic triblock copolymer combining hydrophilic polyethylene glycol (PEG) hydrophobic polylactide glycolide (PLGA) blocks, renowned for its properties conducive crafting biodegradable, temperature‐sensitive hydrogel. This tailored encapsulate ratiometrically designed dual‐loaded liposomes containing first‐line chemo option CS, Doxorubicin (Dox), plus calculated amount of small molecule inhibitor anti‐apoptotic pathway, ABT‐737. vitro in vivo evaluations demonstrate successful suppression, resulting restoration Dox sensitivity, evident through impeded tumor growth amplified necrosis rates at site. system showcases remarkable thermal responsiveness, injectability, biodegradability, all finely aligned with clinical demands CS treatment. Collectively, study introduces transformative avenue tackling chemotherapy, offering significant potential.
Язык: Английский
Процитировано
5Electrochemical Sensor for the Evaluation of Doxorubicin from Novel Pharmaceutical Formulations and Serum
Chemosensors, Год журнала: 2024, Номер 12(4), С. 69 - 69
Опубликована: Апрель 19, 2024
This study focuses on addressing the challenges associated with doxorubicin (DOX), an anthracycline chemotherapeutic widely used in cancer treatment. Despite its efficacy, DOX is linked to severe side effects that limit clinical applications. Novel pharmaceutical formulations aim mitigate these issues, providing better safety profiles. The development of requires analytical methods can accurately and quickly quantify DOX. A cost-effective portable electrochemical sensor for detection was developed utilizing in-house printed carbon electrodes decorated gold nanoparticles. detected using differential pulse voltammetry. demonstrated accurate quantification from novel serum, presenting a dynamic range 1 500 μg/mL low 0.3 μg/mL. method, successfully applied characterize DOX-loaded nanosomes, offers valuable alternative early stages formulation development, reducing costs saving time, while maintaining accuracy.
Язык: Английский
Процитировано
4Enhancing the efficacy of letrozole-loaded PEGylated nanoliposomes against breast cancer cells: In vitro study
Heliyon, Год журнала: 2024, Номер 10(9), С. e30503 - e30503
Опубликована: Апрель 30, 2024
Considering its overall impact on human health, letrozole (Let) has been described as having significant efficacy that could be improved by developing drug delivery systems. the side effects of Let, this study aims to encapsulate Let in liposomes and PEGylated liposome nanoparticles (Lipo-Let-PEG) evaluate cytotoxic MCF-7 breast cancer cell line. For purpose, Lipo-Let-PEG formulation was designed characterized SEM, DLS, FTIR methods, release from optimized stability were measured. Furthermore, cytotoxicity apoptotic studies performed using MTT assay flow cytometric analysis. According experimental data, vesicle size EE% 170.05 ± 4.15 nm 87.21 1.36%, respectively. The cumulative at pH 5.4 7.4 also approximately 60% 50%, results showed Lip-Let-PEG produced more than Lip-Let against cells compatible with normal cells. apoptosis cycle arrest cytometry show caused most increase rates compared other treated groups. In conclusion, can used an anticancer agent arresting progression inducing apoptosis, which applied future prevent development.
Язык: Английский
Процитировано
4Looking back, moving forward: protein corona of lipid nanoparticles
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(23), С. 5573 - 5588
Опубликована: Янв. 1, 2024
Intelligent delivery of lipid nanoparticles can be achieved through rational design protein corona as a “troublemaker”.
Язык: Английский
Процитировано
4Preparation and characterization of nisin‐loaded chitosan nanoparticles functionalized with DNase I for the removal of Listeria monocytogenes biofilms
Journal of Food Science, Год журнала: 2024, Номер 89(4), С. 2305 - 2315
Опубликована: Фев. 19, 2024
Listeria monocytogenes biofilms represent a continuous source of contamination, leading to serious food safety concerns and economic losses. This study aims develop novel nisin-loaded chitosan nanoparticles (CSNPs) functionalized with DNase I evaluate its antibiofilm activity against L. on contact surfaces. Nisin-loaded CSNPs (CS-N) were first prepared by ionic cross-linking, was covalently grafted the surface (DNase-CS-N). The NPs subsequently characterized Zetasizer Nano, transmission electron microscopy, Fourier transform infrared (FT-IR), X-ray diffraction (XRD). evaluated polyurethane (PU). DNase-CS-N fabricated quality attributes (particle size-427.0 ± 15.1 nm, polydispersity [PDI]-0.114 0.034, zeta potential-+52.5 0.2 mV, encapsulation efficiency-46.5% 3.6%, conjugate rate-70.4% 0.2). FT-IR XRD verified loading nisin binding chitosan. caused 3 log colony-forming unit (CFU)/cm2 reduction biofilm cells, significantly higher than those in (1.4 log), CS-N (1.8 combination (2.2 log) treatment groups. In conclusion, successfully smooth nearly spherical shape, high positive charge, good stability, which is effective eradicate cells surfaces, exhibiting great potential as agents industry. PRACTICAL APPLICATION: are common hazard processing. this study, constructed expected be promising agent
Язык: Английский
Процитировано
3Lipid-based drug delivery for lungs cancer
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 153 - 189
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Cisplatin meets liposomes for a smarter delivery: A review
Talanta, Год журнала: 2025, Номер 295, С. 128331 - 128331
Опубликована: Май 14, 2025
Язык: Английский
Процитировано
0Preparation of RGD-modified liposomes encapsulated with shikonin and its targeted anti-melanoma effects
Frontiers in Oncology, Год журнала: 2025, Номер 15
Опубликована: Май 27, 2025
Melanoma is the most aggressive skin tumor, and conventional treatment ineffective. Studies have shown that shikonin, derived from traditional Chinese medicine Lithospermum erythrorhizon , has various anticancer activities. In this work, RGD- modified liposomes encapsulated with shikonin (RGD-Lip-SHK) were prepared by thin- film dispersion, which could highly recognize integrin α V β 3 on surface of melanoma cells. RGD-Lip-SHK appeared as spheroid-like vesicles a particle size approximately 120 nm, its ξ-potential was negative. remained stable in serum within 48 h possessed sustained-release effect. vitro compared non -targeted (Lip-SHK), more efficiently taken up, had higher cytotoxicity, better targeted to inhibit cell growth, migration, invasion, boost apoptosis regulating expression Bcl-2 Bax proteins vivo strongest anti-melanoma effect -mediated endocytosis long circulation time inhibited tumor growth B16F10 tumor-bearing mice other groups. Furthermore, histology major organs body weight showed less toxicity. summary, these results indicated great potential for melanoma, expected become novel effective strategy tumor-targeted therapy.
Язык: Английский
Процитировано
0Neurotoxicity of the antineoplastic drugs: “Doxorubicin” as an example
Journal of Molecular Histology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
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