Aesthetic Cosmetology and Medicine,
Год журнала:
2023,
Номер
12(5), С. 169 - 174
Опубликована: Окт. 1, 2023
In
recent
years,
cosmetics
containing
substances
of
natural
origin
have
become
increasingly
popular.
Turmeric
and
the
bioactive
extracted
from
it,
are
subjects
research
not
only
in
medicine
but
also
to
demonstrate
positive
effects
turmeric
on
skin
conditions.
The
study
aimed
present
results
scientific
potential
applications
its
isolates
dermocosmetics.
Recents
studies
indicate
that
curcumin
isolated
has
strong
antioxidant
activity
photodamageminimising
properties.
Additionally,
due
inhibition
enzymes
responsible
for
degradation
collagen
elastin
skin,
is
expected
be
used
formulations
reduce
signs
ageing.
On
other
hand,
antiinflammatory
antimicrobial
active
can
applied
preparations
intended
acne-prone
skin.
It
important
ingredients
cosmetic
preparation
provide
stability
increase
their
penetration
into
deeper
layers
Antioxidants,
Год журнала:
2024,
Номер
13(5), С. 586 - 586
Опубликована: Май 10, 2024
Several
medicinal
herbal
plants
are
extensively
used
as
sources
of
bioactive
compounds
with
beneficial
effects
on
human
health.
This
study
assessed
the
procyanidin
and
polyphenol
profiles
together
antioxidant
potential
seven
medical
matrices.
To
achieve
this
aim,
extraction
from
grape
pomace
was
optimized
validated
by
monitoring
monomeric-trimeric
procyanidins.
The
proposed
quantification
method
applied
to
herbs,
it
proved
be
a
very
efficient
protocol
for
procyanidin-rich
extracts
analysis.
In
addition,
Paullinia
cupana
Kunth.
seed
identified
rich
source
procyanidins
(about
5
mg/g
dry
matrix
each
dimeric
about
3
trimeric)
high
properties.
polyphenolic
profile
HPLC-HESI-MS/MS
in
vitro
activity
evaluated
DPPH
assay
explore
properties
extracts,
which
were
substantially
higher
Peumus
boldus
Molina
leaves
(935.23
±
169
μmol
Trolox
equivalent/g
weight)
concerning
other
Moreover,
Pearson
coefficient
value
observed
between
total
flavonoid
content
(TFC)
comparison
(TPC)
DPPH,
indicating
flavonoids
principal
extracts.
As
a
key
genus
in
Zingiberaceae,
Curcuma
is
widely
studied
for
its
taxonomic
diversity,
the
presence
of
bioactive
curcuminoids
and
volatile
oils,
extensive
applications
traditional
medicine
economic
products
such
as
spices
cosmetics.
Although
chloroplast
genomes
have
been
assembled
published
over
20
species,
mitochondrial
genomic
data
remain
limited.
We
successfully
sequenced,
assembled,
annotated
mitogenome
amarissima
(C.
amarissima)
using
both
Illumina
short
reads
Nanopore
long
reads,
achieving
first
complete
characterization
Zingiberaceae
family.
The
C.
features
unique
multi-branched
structure,
spanning
6,505,655
bp
consisting
39
distinct
segments.
It
contains
total
43
protein-coding
genes,
63
tRNA
4
rRNA
with
GC
content
44.04%.
Codon
usage
analysis
indicated
weak
bias,
neutrality
plot
suggesting
natural
selection
factor
shaping
codon
amarissima.
provides
valuable
insights
into
genome
size,
coding
structural
features,
RNA
editing,
repetitive
sequences,
sequence
migration,
enhancing
our
understanding
evolution
molecular
biology
mitochondria
Zingiberaceae.
high
frequency
repeat
sequences
may
contribute
to
stability
mitochondria.
Comparing
genome,
phylogenetic
based
on
establishes
foundation
further
exploration
evolutionary
relationships
within
In
short,
characterized
here
advances
organization
offers
useful
resources
that
support
future
breeding,
germplasm
conservation,
studies,
though
research
necessary.
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 10, 2025
Migraines
are
neurological
disorders
which
significantly
impact
quality
of
life.
Current
pharmacological
treatments
often
have
adverse
effects,
prompting
the
search
for
alternatives
with
fewer
side
effects.
Several
studies
described
antimigraine
properties
palmitoylethanolamide
(PEA)
and
melatonin.
Our
research
assessed
efficacy
association
hydrodispersible
PEA
(1,200
mg)
melatonin
(0.2
by
a
randomized,
three-month,
double-blind,
placebo-controlled
trial
(PEATONIDE®;
n
=
30
patients;
placebo;
patients).
The
participants
were
recruited
"I.N.B.B.
Consortium"
in
Italy.
primary
outcome
was
reduction
migraine
frequency,
while
secondary
outcomes
included
intensity,
duration,
grade
disability.
parameters
self-reported
daily
headache
diary.
formulation
displayed
significant
frequency
(T3
months:
2.2
±
0.4
MMDs;
T0
baseline:
3.4
0.5
MMDs,
***p
<
0.001
vs
baseline
T0)
disability,
incidence
associated
symptoms
attacks
after
3
months
treatment.
No
effects
observed
during
In
addition,
mitigation
migraine-related
symptomatology
observed.
These
findings
suggest
that
PEATONIDE®
may
be
promising
adjunctive
approach
management.
However,
given
relatively
small
sample
size,
further
large-scale
multicenter
trials
needed
to
confirm
its
clinical
applicability
broader
population.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 6, 2025
Turmeric,
also
referred
to
as
Curcuma
longa,
is
a
commonly
used
spice,
recognized
for
its
demonstrated
effects
in
reducing
inflammation,
combating
microbes,
providing
antioxidant
benefits,
slowing
the
aging
process,
and
exhibiting
anticancer
potential.
The
process
of
skin
intricate,
with
ultraviolet
radiation
being
significant
extrinsic
factor.
Increasing
evidence
suggests
that
curcumin,
active
component
turmeric,
can
prevent
radiation-induced
photoaging
related
inflammation.
Its
include
inhibition
melanin
production,
wrinkle
reduction,
anti-inflammatory
actions.
This
review
primarily
focuses
on
specific
signaling
pathways
involved
mechanisms
by
which
curcumin
mitigates
photoaging.
Key
topics
properties
regulation
matrix
metalloproteinase,
autophagy
apoptosis,
improvement
pigmentation,
microbial
balance.
Additionally,
addressing
critical
issue
curcumin's
low
bioavailability,
summarizes
latest
advancements
formulation
improvements.
article
aims
provide
comprehensive
overview
progress
research
offer
further
clinical
application
dermatological
treatments.
contributes
deeper
understanding
potential
molecular
presents
new
insights
development
curcumin-based
anti-photoaging
products.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(9), С. 1300 - 1300
Опубликована: Сен. 14, 2023
The
process
of
skin
aging
is
a
physiological
phenomenon
that
can
not
be
avoided.
According
to
global
population
data,
the
rate
increases
by
approximately
13%
every
year.
impact
has
become
significant
concern
and
challenge
for
developed
countries.
Consequently,
there
been
search
potential
new
anti-aging
agents.
This
review
aims
provide
an
overview
current
research
status
plants
Anak
Dalam
Tribe
(Indonesian:
Suku
[SAD];
referred
as
SAD
henceforth)
in
Jambi
Province,
Indonesia,
development
One
such
discovery
product
derived
from
natural
ingredients
with
ability
prevent
premature
aging.
These
have
used
centuries
tribe,
treating
diseases
maintaining
health
through
traditional
remedies.
Recent
on
herbal
formulations
community
Indonesia
beauty
treatments,
reported
Research
Medicinal
Plants
Herbs
or
RISTOJA,
indicates
64
plant
species
are
care.
Among
these
plants,
Toona
sinensis,
Curcuma
heyneana,
zedoaria,
longa,
Kaempferia
rotunda
most
commonly
medicinal
properties.
T.
sinensis
tree,
while
others
herbs.
shows
highest
agent,
its
extracts,
active
fractions,
bioactive
quercetin
isolates
known
possess
strong
activities
both
vitro
vivo.
Furthermore,
C.
K.
also
show
further
research,
three
them
demonstrated
good
vivo
activities.
Only
demonstrates
relatively
weaker
antioxidant
activity
compared
zedoaria.
Nevertheless,
still
opportunities
agents
other
activities,
zedoaria
findings
could
opportunity
explore
In
conclusion,
five
traditionally
Jambi,
longa
received
extensive
solutions.
heyneana
activity.
least-studied
plant.
it
development,
widely
medicine
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(8), С. 4282 - 4282
Опубликована: Апрель 12, 2024
In
recent
years,
there
has
been
increasing
interest
in
utilizing
Traditional
Chinese
Medicine
principles
and
natural
bioactive
compounds
to
combat
age-related
ailments
enhance
longevity.
A
Cordyceps
sinensis
mycelium
hydroethanolic
extract
(CsEx),
which
was
standardized
cordycepin
adenosine
using
UHPLC-DAD,
investigated
for
its
adaptogenic
properties
vitro
assays
a
double-blind,
placebo-controlled
clinical
trial
involving
40
subjects.
The
CsEx
demonstrated
activity
at
concentration
of
0.0006%,
significantly
sirtuin
expression
(SirT1:
+33%,
SirT3:
+10%,
SirT6:
+72%,
vs.
CTR,
p
<
0.05)
NAD+
synthesis
HaCat
cells
(+20%
0.001).
Moreover,
the
boosted
ATP
production
by
68%
skin
cells,
correlating
with
higher
energy
values
(+52.0%
D28,
0.01)
trial.
Additionally,
notably
reduced
cytosolic
reactive
oxygen
species
(ROS)
30%
HaCaT
(p
enhanced
collagen
both
(+69%
vivo
(+10%
D0,
0.01),
confirmed
ultrasound
examination.
Furthermore,
CsEx’s
stimulation
fibroblasts,
coupled
antioxidant
energizing
properties,
led
significant
reduction
wrinkles
28.0%
(D28,
This
study
underscores
extract’s
potential
regulating
cell
metabolism
positively
influencing
mechanisms
associated
longevity
control.
Antioxidants,
Год журнала:
2024,
Номер
13(5), С. 610 - 610
Опубликована: Май 16, 2024
Environmental
contamination
by
heavy
metals
(HMs)
has
emerged
as
a
significant
global
issue
in
recent
decades.
Among
natural
substances,
food-deriving
polyphenols
have
found
valuable
application
chelating
therapy,
partially
limited
their
low
water
solubility.
Thus,
three
different
hydroalcoholic
extracts
titrated
quercetin
(QE),
ellagic
acid
(EA),
and
curcumin
(CUR)
were
formulated
using
maltodextrins
carriers,
achieving
powder
with
solubility
(MQE
91.3
±
1.2%,
MEA
93.4
2.1,
MCUR
89.3
2%).
Overcoming
the
problem
of
solubility,
such
formulations
tested
an
vitro
simulated
gastrointestinal
digestion
experiment
conducted
on
sample
standardized
concentrations
principal
HMs.
Our
results
indicate
that
regarding
nonessential
HMs
investigated
(Pb,
Cd,
As,
Sb,
Hg),
MQE
been
shown
to
be
most
effective
increasing
HMs’
non-bioaccessible
concentration,
resulting
concentration
increases
Cd
68.3%,
As
51.9%,
Hg
58.9%,
Pb
271.4,
Sb
111.2%
(vs
control,
p
<
0.001)
fractions.
Regarding
essential
HMs,
greatest
capability
increase
intestinal
bioaccessibility,
+68.5%,
+61.1,
+22.3%
Cu,
Zn,
Fe,
respectively.
Finally,
considering
strong
relation
between
antiradical
activities,
radical
scavenging
potentials
was
assayed
DPPH
ABTS
assays.
Background
Facial
skin
has
an
essential
cosmetic
function
in
both
men
and
women,
photoaged
can
affect
the
quality
of
life
healthy
people.
Ashwagandha
(Withania
somnifera)
which
is
also
called
Indian
ginseng
adaptogenic
properties
used
traditional
medicine
to
maintain
balance,
energize,
rejuvenate.
Objective
This
randomized,
double-blind,
placebo-controlled
study
assessed
efficacy
safety
topical
application
lotion
containing
8%
standardized
root
extract
on
improvement
parameters
facial
subjects.
Methods
Fifty-six
women
aged
between
18
60
years
with
Fitzpatrick
phototype
III-VI
grade
were
randomized
receive
(lotion
skin)
either
(AG,
n=28),
or
identical
placebo
(PL,
n=28)
for
days.
The
primary
outcome
was
change
from
baseline
day
scores
global
physician
assessment
scoring
five
dermatological
signs
(skin
wrinkles,
pores,
hydration/moisture,
brightness/tone,
pigmentation)
skin.
Secondary
outcomes
changes
transepidermal
water
loss
(TEWL),
melanin
index,
hydration,
elasticity
(R2
ratio).
Another
using
health-specific
Short
Form
Health
Survey-12
(SF-12).
Safety
local
reactions
adverse
events.
Three
(1
AG,
2
PL)
patients
lost
follow-up
per-protocol
(PP)
data
included
53
(27
26
PL).
For
measurement
data,
repeated
measures
analysis
variance
(ANOVA)
assess
treatment
effect
at
different
time
periods
PP
dataset
(n=53).
Two
groups
compared
differences
a
t-test
continuous
Mann-Whitney
‘U’
test
ordinal
data.
Adverse
events
two
chi-square
test.
Results
Greater
reduction
(p<0.0001)
total
observed
AG
(-74.69%)
PL
(-48.68%).
There
greater
TEWL,
ratio)
as
(p<0.0001).
However,
index
similar
end
(p=0.969).
percentage
increase
by
-2.82%
-1.78%
PL,
whereas
TEWL
-15.12%
-8.34%
PL.
Similarly,
improvements
seen
hydration
(20.66%
9.5%
R2
ratio
(16.34%
3.73%
comparable
groups.
Conclusions
Topical
improves
condition
individuals.
Further
studies
types
standard
comparators
are
warranted
substantiate
these
claims
benefit.
Cosmetics,
Год журнала:
2024,
Номер
11(6), С. 205 - 205
Опубликована: Ноя. 26, 2024
This
study
aims
to
explore
the
impact
of
aging
on
skin
elasticity,
a
key
biomechanical
property
that
diminishes
over
time,
using
Cutometer
assess
viscoelastic
parameters.
Methods:
Researchers
analyzed
22
parameters
from
facial
60
women
aged
18
70.
Key
Results:
The
findings
indicate
relaxation
phase
parameters,
particularly
biological
elasticity
(R7),
exhibited
strongest
negative
correlation
with
age
(r
=
−0.62),
signifying
notable
decline
in
as
age.
In
contrast,
maximum
deformation
during
first
cycle
(R0)
and
total
area
under
upper
curve
after
10
cycles
(F4)
also
showed
significant
correlations
−0.47,
r
−0.48),
suggesting
younger
typically
presents
higher
values.
These
raise
questions
regarding
practical
applications,
presence
moisturizers
emollients
may
alter
stratum
corneum’s
properties,
thus
impacting
these
measurements.
Additionally,
ratio
delayed
instantaneous
(R6)
demonstrated
positive
0.49),
indicating
its
potential
marker
for
aging.
Conclusions:
highlights
critical
role
accurately
reflecting
changes
associated
results
offer
valuable
insights
evaluating
cosmetic
efficacy,
reinforcing
need
nuanced
understanding
how
various
interact.
contribute
ongoing
development
more
effective
anti-aging
treatments
products.