Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Nutrients, Год журнала: 2024, Номер 16(1), С. 154 - 154
Опубликована: Янв. 2, 2024
Endometriosis is a chronic, hormone-dependent disease characterized by the presence of endometrial tissue in ectopic locations. Since treatment options for this are still limited, and cure rate unsatisfactory, search ways to treat symptoms modify course key importance improving quality life patients with endometriosis. So far, literature has shown that nutrition can influence endometriosis through hormonal modification altering inflammatory or oxidative response. subject scientific research, we aimed summarize current knowledge on role dietary modifications Our review showed nutrients anti-inflammatory antioxidant properties, including most vitamins several trace elements, may pathogenesis be considered as preventing development However, despite many discoveries described review, further interdisciplinary research topic seems extremely important, future, it result personalized therapies supporting
Язык: Английский
Процитировано
13
Phytotherapy Research, Год журнала: 2024, Номер 38(6), С. 3060 - 3079
Опубликована: Апрель 11, 2024
Abstract Phytoestrogens, also known as xenoestrogens, are secondary metabolites derived from plants that have similar structures and biological effects human estrogens. These compounds do not directly affect functions but can act agonists or antagonists depending on the level of endogenous estrogen in body. Phytoestrogens may an epigenetic mechanism action independent receptors. found more than 300 plant species synthesized through phenylpropanoid pathway, with specific enzymes leading to various chemical structures. primarily phenolic compounds, include isoflavonoids, flavonoids, stilbenes, lignans. Extensive research animals humans has demonstrated protective phytoestrogens estrogen‐dependent diseases. Clinical trials shown their potential benefits conditions such osteoporosis, Parkinson's disease, certain types cancer. This review provides a concise overview phytoestrogen classification, diversity, biosynthesis discusses therapeutic phytoestrogens, well preclinical clinical development.
Язык: Английский
Процитировано
8
Cancer Letters, Год журнала: 2024, Номер 598, С. 217116 - 217116
Опубликована: Июль 14, 2024
Язык: Английский
Процитировано
8
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Март 3, 2025
Formononetin (FMN) is a common natural metabolite that can be extracted and isolated from some botanical drugs. In recent years, FMN has garnered increasing attention due to its beneficial biological activities. this paper, we systematically summarize the sources of provide comprehensive review pharmacological activities molecular mechanisms, co-administration, toxicity, derivatives, drug delivery systems in last 5 years. The study results found wide range neurological disorders, organ damage cancer, showing great potential for clinical application broad prospects. Researchers are exploring various types systems, including nanoparticle carriers, ligand modifications polymer microspheres. These advanced enhance stability FMN, prolong release time vivo , improve targeting, thereby optimizing therapeutic efficacy reducing side effects, greatly improving bioavailability. conclusion, with considerable research value, diverse make it promising candidate development medical research.
Язык: Английский
Процитировано
0
Journal of Pharmaceutical and Biomedical Analysis, Год журнала: 2025, Номер 260, С. 116819 - 116819
Опубликована: Март 11, 2025
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Март 12, 2025
Dietary phytoestrogens have been suggested to provide protection against numerous age-related diseases. However, their effects on biological aging remain unclear. In this study, we cross-sectionally investigated the relationship between urinary phytoestrogen levels and indicators of using data from 7,981 adults who participated in National Health Nutrition Examination Survey 1999–2010. Urinary concentrations six phytoestrogens, including four isoflavones two enterolignans, were measured high-performance liquid chromatography (HPLC)-tandem mass spectrometry (MS) or HPLC-atmospheric pressure photoionization-tandem MS, standardized creatinine. Three age (BA), namely Klemera-Doubal method (KDM-BA), phenotypic (PA), homeostatic dysregulation (HD), derived 12 clinical biomarkers, advanced-BAs calculated quantify differences individuals' BAs chronological age, individuals with all positive defined as accelerated-aging. Weighted linear regression analysis showed that after adjusting for demographic lifestyle factors history chronic diseases, elevated total enterolignans significantly associated less advanced-KDM, advanced-PA, advanced-HD, whereas was advanced-KDM advanced-PA but not advanced-HD. logistic higher (highest Q4 vs. lowest Q1: OR = 0.60, 95%CI: 0.44, 0.80; P-trend 0.002) (Q4 0.59, 0.45, 0.76; < 0.001) lower odds accelerated-aging, significant 0.78, 1.08; 0.05). Subgroup analyses negative associations attenuated non-overweight/obese participants current cigarette smokers. conclusion, are related markers slower aging, suggesting an anti-aging effect dietary consumption, which warrants further investigations longitudinal interventional settings.
Язык: Английский
Процитировано
0
Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119646 - 119646
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Women s Health, Год журнала: 2024, Номер Volume 16, С. 693 - 705
Опубликована: Апрель 1, 2024
Postmenopausal osteoporosis stands as the predominant bone disorder in developed world, posing a significant public health challenge. Nutritional factors play crucial role and may contribute to its prevention or treatment. Calcium vitamin D, extensively studied with robust scientific evidence, are integral components of non-pharmacological treatment for this disorder. Nevertheless, other less-explored nutritional elements appear influence metabolism. This review provides comprehensive summary latest evidence concerning relationship between various nutrients, such phosphorus, magnesium, vitamins, phytate, phytoestrogens; specific foods like dairy soy, dietary patterns Mediterranean diet osteoporosis.
Язык: Английский
Процитировано
4
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Авг. 8, 2024
Thin endometrium (TE) is closely associated with infertility in reproductive medicine. Estrogen therapy gains unsatisfactory outcomes. In this study, an artificial mucus based on dopamine (L-DOPA)-modified hyaluronic acid combining phytoestrogen cajaninstilbene and rat urinary exosomes (CUEHD) constructed for TE treatment using a model. the model, dominant elastic behavior adhesive properties of CUEHD guarantee adequate retention, rendering superior synergistic efficacy favorable biosafety characteristics. significantly increases endometrial thickness promotes receptivity fertility. Mechanistically, estrogen homeostasis, inflammation inhibition, regeneration are achieved through crosstalk between ER-NLRP3-IL1β Wnt-β catenin-TGFβ-smad signaling pathways. Moreover, therapeutic potential from human urine adipose tissue-derived stem cells (ADSCs) ADSCs also demonstrated, indicating extensive use system. Thus, study illustrates platform promising implications treatment.
Язык: Английский
Процитировано
4