Study on the spectrum-effect correlation of phytoestrogenic activity of total flavonoids from Cynomorii Herba

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119646 - 119646

Опубликована: Март 1, 2025

Язык: Английский

---

Natural products and cancer: From drug discovery to prevention and therapy

British Journal of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 23, 2025

Natural products represent compounds that have been isolated from plants, animals and other organisms. Along with their structural analogues, they had continue to a relevant role in anticancer drug discovery, by offering the advantage of fixed chemical structure higher specificity for target proteins protein–protein interactions (Atanasov, Zotchev, Dirsch, International Product Sciences, & Supuran, 2021) (Figure 1). Some widely used drugs originate natural sources, many are cancer patients as part complementary integrative approach healthcare (Frenkel et al., 2023). bioactive compounds, including, but not limited to, vast class polyphenols, shown act sensitizers treatments (e.g., chemotherapy radiotherapy), promoting mode action, reducing therapy resistance or lowering side/adverse effects (Lin 2020). By affecting apoptosis, cell cycle progression, checkpoints, DNA damage repair mechanisms, epithelial-mesenchymal transition (EMT), migratory properties, immune response, processes, modulate, mediate enhance action therapeutics 2020; Nan 2022). The cells tumour microenvironment currently special interest leading development novel therapies, such recently FDA-approved lifileucel (Amtagvi), first treatment uses tumour-infiltrating lymphocytes solid - advanced melanoma (Julve 2024). Dietary approaches, caloric restriction sensitivity T-cell-mediated killing, nutrients, vitamin C improve functionality cells, substances, apigenin, anthocyanin, epigallocatechin gallate others increase inhibiting PD-1 PD-L1 on can help fight boosting system preventing immunosuppression (Golonko In addition these certain products, example, quercetin, curcumin terpenoids, regulate efflux transporters across membrane, well regulation metabolism, thus decreasing risk emergence (Chen Antioxidant, anti-inflammatory immunomodulatory actions further support anti-cancer alleviating and/or eliminating side adverse (Ilghami Such diverse activities associated wide range molecular targets (Hashem Next generation sequencing methods mapped multiple genes signalling pathways targeted (Beetch Harandi-Zadeh 2021; Lubecka 2016). Various including epigenetics will be discussed one paragraphs below, implicated For instance, key upstream regulators oncogenic pathways, Notch, Wnt, Hedgehog, PI3K / Akt MAPK, which control survival, proliferation, differentiation transformation, were reported suppressed polyphenols via epigenetic gene silencing Kurzava Kendall Because simultaneously affect signal transduction may prevent overcome when specific pathway inhibitors used. Taking into account combination treatments, fundamental research is crucial (Arora 2022; Rahman Knowledge mechanisms off-target avoid toxicity treatments. Cases hepatotoxicity were, indeed, single combined applications plant-based Hence, investigating identifying depend applied dose establishing safe effective approaches. Findings numerous preclinical studies, vitro vivo models, allow databases modelling Indeed, advances computational along machine learning artificial intelligence potential discovering product-based candidate molecules promising efficacy (Chunarkar-Patil Modelling outcomes must validated well-designed experimental studies determine pharmacokinetics, bioavailability, toxicity, existing drugs. Nevertheless, this has promise result safer more therapies. integration technologies mechanistic product areas pharmacology accelerated progress clinical trials conventional chemotherapeutics cisplatin, gemcitabine docetaxel) bioactives herbal extracts traditional Chinese medicine) It facilitates prevention where most focus purified directed populations at cancer. green tea was individuals high prostate (Kumar 2015; Kumar 2018), whereas spice turmeric pre-cancerous lesions colon (Cruz-Correa 2018, 2006). Many yielded inconclusive results, partially due possible confounding factors groups already On hand, primary among general healthy population lacking. A recent umbrella review meta-analyses association between Mediterranean diet different health demonstrates tremendous dietary pattern protecting cancer; however, findings come mostly observational rather than randomized (Dinu 2018; Mentella 2019). More trials, larger sample size, longer follow-up, compound formulations needed strengthen evidence. themed issue British Journal Pharmacology, we assembled seven articles summarizing some new developments area. addition, two included, report newly discovered cancer-relevant reporting synthesis analogues based strategies. phytochemicals inhibit angiogenesis (Marrero 2022) autophagy (Braicu makes them attractive prevention. Two (Lu 2023; Wang 2023) developing anti-angiogenic agents. Furthermore, article Dong colleagues reports product, polyphyllin D, inhibitor chaperone-mediated (Dong Lu comprehensively role, limitations targeting Specifically, authors summarize several molecules, polysaccharides, alkaloids, terpenoids saponins. Also, paper highlights challenges phytochemical extraction poor bioavailability mentioned strategy therapeutic and, finally, emphasizes emerging technology computer-aided design an opportunity develop natural-based chemopreventive effect flavonoids attributed various modulation autophagy, induction arrest, antioxidant (Gupta another our issue, specifically focused breast (Wang capture discuss data culture experiments, trials. value nanotechnological approaches delivery highlighted, need comprehensive robust deeper understanding pharmacodynamic basis subsequent evaluation While studied decades, relatively process under investigation therapies (Debnath involves misfolded damaged organelles lysosomes, degradation recycling, plays maintenance cellular homeostasis. This selective type namely highly active protein Although governing known, lysosomal membrane (LAMP2A) knockdown process, yet discovered. After screening, provide evidence D non-small lung Polyphyllin belongs saponins disrupts interaction LAMP2A HSC70 (HSPA8) which, turn, blocks autophagy. Applying next technology, Another group plant spectrum anti-tumour isoquinoline sinomenine (also known cocculine, picrotoxin), phenolic base resembling polyphenol. Li detailed overview (Li From actions, Akt, AMPK STAT3, mTOR NFκB, major angiogenesis, EMT, metastasis resistance. Interestingly, leads downregulation energy metabolism enzymes attenuation glycolysis explain anti-proliferative effects. also point unique ability impact neurotransmitter levels nervous system, pain analgesic management side-effects peripheral neuropathy). Pancreatic causes death worldwide its global burden doubled over past 25 years (Klein, 2021). Casarcia pancreatic cancer, highlighting (Casarcia plethora experiments consistently growth decrease size animal models. Main include pro-apoptotic factors, antiapoptotic arrest. Signalling modulated Ras Wnt β-catenin Isoflavones belong flavonoids, polyphenols. Due similarity 17β-oestradiol oestrogen-like phytoestrogen family. As secondary metabolites, isoflavones advocated exert broad benefits humans (Patra Kaufman-Szymczyk soy-derived (Kaufman-Szymczyk discussed: (1) isoflavones; (2) latest regarding (3) epidemiological showing intake hormone-related hormone-independent cancers (4) current future directions, opportunities increasing achieve desirable patients. Those easily translated well. use probiotics microbial packaging systems formulation hydrocolloids micelles), described Yang colleagues, (Yang 2025) included present modified sinomenine, alkaloid. Modification C-ring condensation helped short biological half-life unstable physicochemical properties parent 2025). derivative, 7 l, against glioblastoma, enhancing biogenesis, transcription factor EB (TFEB) pathway, results death. Epigenetics refers dynamic changes expression without underlying sequence. term 'epigenetics' includes methylation, histone covalent modifications, non-coding RNA chromatin-remodelling complexes Reversibility aberrations signature it excellent area pharmacological research. developed approved therapeutics, especially azacitidine (Vidaza) decitabine (Dacogen) methylating enzymes, vorinostat (Zolinza)and tazemetostat (Tazverik) deacetylases (HDAC) methyltransferases (HMTs), respectively, blood (Feehley epi-drugs derivatives (Akone sodium phenylbutyrate, derivative short-chain fatty acid, butyric taurursodiol (TUDA), HDAC amyotrophic lateral sclerosis. inhibitor, bicyclic depsipeptide romidepsin, naturally produced Chromobacterium violaceum T-cell lymphoma Anti-cancer researched modulators histone-modifying Dorna (Dorna underappreciated topic methylation demethylation, elaborate influence activity involved methylation/demethylation lysine arginine residues proteins. pieces curcuminoids, stilbene derivatives, acids, isothiocyanates, alkaloids terpenes discussed. indicate lysine-specific demethylase (LSD1) methyltransferase (EZH2) modifying An interesting conclusion genistein, sulforaphane acid) often (e.g, methylation). appears lead enhanced commented isoflavones, micro-RNAs modifications (DNA methylation/demethylation) acetylation/deacetylation, describe long RNA, HEIH, attenuating migration bladder likely depending target, context. previous show stilbenoids DNMT3A binding suppressor activation Simultaneously, same DNMT3B oncogenes DNMT3B-dependent continued Kleszcz tannins (including (EGCG)) regulating acetylation (Kleszcz give encompass arrest endoplasmic reticulum stress metabolism. Combinations radiotherapy emphasized potentially strategies multidrug resistance, referencing growing body application nano-vehicles diagnostics introduced exciting using tannins, tannic generate drug-loaded nanoparticles combinatorial effects, leveraged build tannin-functionalized circulating summarized. Advancements personalized nutrition transformed field occurring nutritional interventions Omics revealing prevention, aim stop developing, interception, halt early stages (Sauter Mohammed, latter increased liver cirrhosis colorectal adenomas. anti-oxidant commonly exerted bring benefits. contrary, fully tumours actually capacity oxidative thrive, requires attention studies. One nutrients products/bioactive fact difficult detect inability eliminate study intervention isolation, lifestyle confound exercise sleep quality), differences quality purity (production reproducibility), others. Thus, large sizes required meaningful conclusions. Scientific scrutiny regard design, characteristics cohorts doses, important consider path consistency results. aspect dual Cancer type, stage, concentration, exposure regimens main biphasic addressed safety alone drugs, interests Deciphering establish adjuvant would agents, attenuate protect Mechanistic investigations facilitate improved preventive creating culturally inclusive Utilizing discovery creates bridge Western medicine Indigenous healing. Integrating knowledge perspectives might importance biodiversity fostering sustainable practices. Key ligands hyperlinked corresponding entries https://www.guidetopharmacology.org, permanently archived Concise Guide PHARMACOLOGY 2021/2022 (Alexander Angelo A. Izzo Barbara Stefanska contributed equally work. They wrote revised manuscript. created figure. No conflict declare.

Язык: Английский

---

Complementary and Alternative Therapies for Vasomotor Symptoms During Climacteric and Beyond

Опубликована: Янв. 1, 2025

Язык: Английский

---

Chemistry and pharmacology of lignans and stilbenes reported in African medicinal plants

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 465 - 497

Опубликована: Янв. 1, 2025

Язык: Английский

---

Clovamide and Its Derivatives—Bioactive Components of Theobroma cacao and Other Plants in the Context of Human Health

Foods, Год журнала: 2024, Номер 13(7), С. 1118 - 1118

Опубликована: Апрель 6, 2024

Clovamide (N-caffeoyl-L-3,4-dihydroxyphenylalanine, N-caffeoyldopamine, N-caffeoyl-L-DOPA) is a derivative of caffeic acid, belonging to phenolamides (hydroxycinnamic acid amides). Despite growing interest in the biological activity natural polyphenolic substances, studies on properties clovamide and related compounds, their significance as bioactive components diet, well effects human health are relatively new research trend. On other hand, vitro vivo evidence indicates considerable potential these substances context maintaining or using them pharmacophores. The name “clovamide” directly derives from red clover (Trifolium pratense L.), being first identified source this compound. In clovamides mainly present chocolate cocoa-containing products. Furthermore, occurrence some medicinal plants has also been confirmed. literature reports deal with antioxidant, anti-inflammatory, neuroprotective, antiplatelet/antithrombotic anticancer clovamide-type compounds. This narrative review summarizes available data health-supporting properties, including prospects for use compounds therapeutic purposes.

Язык: Английский

---

Effect of hyperoside on osteoporosis in ovariectomized mice through estrogen receptor α/ITGβ3 signaling pathway

European Journal of Pharmacology, Год журнала: 2024, Номер 977, С. 176666 - 176666

Опубликована: Май 24, 2024

Язык: Английский

---

The What and Who of Dietary Lignans in Human Health: Special Attention to Estrogen Effects and Safety Evaluation

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(44), С. 16419 - 16434

Опубликована: Окт. 23, 2023

Lignans are a group of phenolic compounds found in plant-based diets. The human body can obtain lignans through diet, which then metabolized into enterolignans. enterolignans have been linked to several health benefits, including anticancer, anti-inflammatory, antioxidant effects, and estrogen effects. This review explores the relationship between estrogenic effects health. not only considers estrogen-like activity but also discusses safe dosage at different life stages. In addition, this identified other types bioactive that act synergistically with promote Studies shown lignan administration during pregnancy lactation reduces risk breast cancer offspring. Further studies needed investigate safety on pregnant women children. Whether combine nutrients complex food substrates produce synergistic remains be investigated. provides basis for future dose recommended dietary intake lignan. We believe acquired as discussed here has implications developing therapies host nutrition modulate diseases.

Язык: Английский

---

From Plant to Patient: The Metabolic Benefits of Phytoestrogens

IntechOpen eBooks, Год журнала: 2024, Номер unknown

Опубликована: Фев. 29, 2024

In recent years, there has been a growing interest in the potential health benefits of phytoestrogens, diverse group naturally occurring compounds found plants. These compounds, with structural similarities to estrogen, are foods such as soybeans, flaxseeds and sesame seeds, studied for their roles modulating hormonal activity antioxidant properties. Their estrogen-like functions make them particularly interesting managing conditions exacerbated by imbalances, type 2 diabetes, obesity, cardiovascular diseases, osteoporosis. Phytoestrogens enhance insulin sensitivity glucose metabolism, while anti-oxidant properties neutralize free radicals inhibit lipid peroxidation. They also influence fat metabolism reduce adipogenesis, addressing oxidative stress inflammation. estrogenic effects improve bone mineral density fracture risks, postmenopausal women, highlighting broad metabolic disease management. This body research suggests that due unique mechanisms action, could be valuable addition dietary therapeutic strategies prevention management various diseases. chapter delves into multifaceted phytoestrogens disorders, special focus on

Язык: Английский

---

The Mechanism Involved in the Inhibition of Resveratrol and Genistein on the Contractility of Isolated Rat Uterus Smooth Muscle

Nutrients, Год журнала: 2024, Номер 16(19), С. 3417 - 3417

Опубликована: Окт. 9, 2024

Purpose: This study aimed to compare the effects of phytoestrogens resveratrol (RES) and genistein (GEN) on contractility isolated uterine smooth muscle from rats, focusing both spontaneous stimulated contractions, investigate underlying mechanisms. Methods: Uterine strips were suspended vertically in perfusion chambers containing Kreb’s solution, various concentrations RES GEN added ex vivo strips, contractions measured before after incubation with or GEN. Results: (1) Both inhibited K+-induced a dose-dependent manner; β/β2-adrenoceptor antagonist propranolol (PRO), ICI118551, ATP-dependent K+ channel blocker glibenclamide (HB-419) NO synthase inhibitor N-nitro-L-arginine (L-NNA) diminished inhibitory contractions. (2) also dose-dependently PGF2α-induced (3) The observed contractile activities as well; PRO, HB-419 L-NNA attenuated strips. (4) significantly decreased cumulative concentration response Ca2+ shifted concentration–response curves right high-K+ Ca2+-free solution. (5) markedly reduced first phasic contraction induced by oxytocin, acetylcholine, prostaglandin F2α but did not alter second caused CaCl2 Conclusions: can directly inhibit activated muscle. mechanisms likely involve β adrenergic receptor activation, influx release, activation channels increased production.

Язык: Английский

---

The Influence of Environmental Exposure to Xenoestrogens on the Risk of Cancer Development

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12363 - 12363

Опубликована: Ноя. 18, 2024

Xenoestrogens (XEs) are a group of exogenous substances that may interfere with the functioning endocrine system. They mimic function estrogens, and their sources plants, water or dust, plastic, chemical agents, some drugs. Thus, people highly exposed to actions. Together development industry, number XEs in our environment increases. interact directly estrogen receptors, disrupting transmission cellular signals. It is proven exhibit clinical application e.g., menopause hormone therapy, but studies observed intense exposure leads progression various cancers. Moreover, these ability cross placental barrier, therefore, prenatal disturb fetus development. Due wide range effects resulting from biological activity substances, there need for this knowledge be systematized. This review aims comprehensively assess environmental role increasing cancer risk, focusing on current evidence pathological impacts.

Язык: Английский

---