Poria cocos: traditional uses, triterpenoid components and their renoprotective pharmacology

Acta Pharmacologica Sinica, Год журнала: 2024, Номер unknown

Опубликована: Окт. 31, 2024

Язык: Английский

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An Overview of the Spices Used for the Prevention and Potential Treatment of Gastric Cancer

Cancers, Год журнала: 2024, Номер 16(8), С. 1611 - 1611

Опубликована: Апрель 22, 2024

Gastric cancer (GC) ranks third in terms of cancer-related deaths and is the fifth most commonly diagnosed type cancer. Its risk factors include Helicobacter pylori infection, Epstein–Barr virus consumption broiled charbroiled animal meats, salt-preserved smoke-enhanced foods, alcohol drinking, tobacco smoking, exposure to ionizing radiation, positive family history. The limited effectiveness conventional therapies widespread GC encourage search for new methods treatment prevention. In quest cheap available medications, numerous studies focus on herbal medicine, traditional brews, spices. this review, we outline potential use spices, including turmeric, ginger, garlic, black cumin, chili pepper, saffron, rosemary, galangal, coriander, wasabi, cinnamon, oregano, cardamom, fenugreek, caraway, clove, dill, thyme, Piper sarmentosum, basil, as well compounds they contain, prevention GC. We present molecular mechanisms responsible effectivity a given seasoning substance their impact cells. discuss effects proliferation, apoptosis, migration. For spices discussed, also unavailability side use.

Язык: Английский

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Galangin alleviated Doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through GSTP1/JNK pathway

Phytomedicine, Год журнала: 2024, Номер 134, С. 155989 - 155989

Опубликована: Авг. 31, 2024

Язык: Английский

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Natural flavonoids act as potent ferroptosis inhibitors and their potentials in the treatment of ferroptosis-associated diseases

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2024, Номер 10, С. 100377 - 100377

Опубликована: Янв. 26, 2024

Ferroptosis, an iron-dependent cell death characterized by lethal lipid peroxidation, has been involved in the pathogenesis of various diseases, such as ischemia/reperfusion injury, neurodegenerative and inflammatory disorders. Pharmacological inhibition ferroptosis represents a promising strategy for treatment above diseases. Flavonoids, class natural products found medicinal plants functional foods, are known numerous activities, especially newly discovered anti-ferroptotic activity. Our review aims to expand our understanding flavonoids' activity on multiple biological systems highlight importance utilizing flavonoids ferroptosis-associated A systematic literature search was conducted using Google Scholar, PubMed, Web Science, ScienceDirect, Springer Link. The following keywords: flavonoids, products, ferroptosis, mechanism, available information comprehensively studied compiled. We recent advances molecular mechanisms its roles diverse further systematically summarize inhibitory underlying suggest that ROS accumulation labile Fe2+ availability well activation Nrf2 signaling responsible inhibition. also discuss their clinical applications ferroptosis-related Taken together, exhibit prospect This is expected not only facilitate design development flavonoid-based inhibitors, but diseases therapies.

Язык: Английский

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Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved

Antioxidants, Год журнала: 2024, Номер 13(4), С. 486 - 486

Опубликована: Апрель 18, 2024

Chemotherapy-induced cognitive impairment or "chemobrain" is a prevalent long-term complication of chemotherapy and one the more devastating. Most studies performed so far to identify dysfunctions induced by antineoplastic chemotherapies have been focused on treatment with anthracyclines, frequently administered breast cancer patients, population that, after treatment, shows high possibility long survival and, consequently, chemobrain development. In last few years, different possible strategies explored prevent reduce anthracycline doxorubicin (DOX), known promote oxidative stress inflammation, which strongly implicated in development this brain dysfunction. Here, we critically analyzed results preclinical from years that evaluated potential phenolic compounds (PheCs), large class natural products able exert powerful antioxidant anti-inflammatory activities, inhibiting DOX-induced chemobrain. Several PheCs belonging classes shown be revert morphological damages deficits associated learning, memory, exploratory behavior. We biological molecular mechanisms suggested future perspectives research area.

Язык: Английский

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Theoretical study on ESIPT of flavonol Galangin molecules in different solvents

Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127140 - 127140

Опубликована: Фев. 1, 2025

Язык: Английский

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Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro

Toxics, Год журнала: 2025, Номер 13(3), С. 194 - 194

Опубликована: Март 8, 2025

Propolis has been well known for centuries as a natural preventive and therapeutic agent. Its numerous health benefits are mainly attributed to its high content of phenolic compounds that have remarkable antioxidant activity. Since phenolics may exert dual nature (pro-oxidant antioxidant) the aim this study was investigate safety profile ethanolic extract propolis related flavonoid galangin their ability protect lymphocytes from irinotecan-induced cyto/genotoxicity in vitro. Isolated human peripheral blood were exposed 3 h three concentrations corresponding average daily dose 0.25 mL [propolis 70% ethanol (3:7, w/w)], five- ten-fold higher concentration. Cyto- genoprotective effects tested using cytokinesis-block micronucleus cytome assay. Treatment with selected exerted biocompatibility diminished level cytogenetic damage caused by irinotecan. at same concentration offered stronger protective effect than single galangin. Also, apoptosis prevailing mechanism cell death our experimental conditions. These preliminary results speak favour future investigations other available methods models.

Язык: Английский

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Preventive and Therapeutic Effects of Baicalein, Galangin, and Isorhamnetin in Chronic Liver Diseases: A Narrative Review

Molecules, Год журнала: 2025, Номер 30(6), С. 1253 - 1253

Опубликована: Март 11, 2025

Chronic liver diseases (CLDs), including fatty disease, fibrosis, and cirrhosis, pose significant global health challenges due to the limitedness of therapeutic options. Flavonoids, a class polyphenolic compounds mainly contained in natural sources foods Mediterranean diet, have emerged as potential candidates for protection their anti-inflammatory, antioxidant, anti-fibrotic properties. Baicalein, derived from Scutellaria baicalensis, exhibits hepatoprotective effects by attenuating oxidative stress, inhibiting fibrogenesis, modulating lipid metabolism. Galangin, flavonoid Alpinia officinarum, has demonstrated anti-inflammatory properties, while isorhamnetin, methylated found various fruits herbs, been shown possess qualities, it reduces stress mitigates inflammation CLDs. This narrative review highlights preventive these three flavonoids, emphasizing role promising agents managing CLDs guiding future research.

Язык: Английский

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Network Pharmacology and Experimental Validation Reveal Therapeutic Potential of Propolis in UV-Induced Allergic Dermatitis

Foods, Год журнала: 2025, Номер 14(6), С. 996 - 996

Опубликована: Март 14, 2025

Propolis demonstrates diverse pharmacological properties encompassing antimicrobial, anti-inflammatory, antioxidant, immunomodulatory, and wound-healing activities. This study investigated the therapeutic mechanism of propolis against ultraviolet (UV)-induced allergic dermatitis through an integrated approach combining network pharmacology with in vitro experimental validation. The targets components were conducted PubChem, EMBL-EBI, SEA Search Server databases, disease-associated for atopic related conditions extracted from GeneCards. overlapping between UV-induced screened. Gene Ontology (GO) Enrichment analysis Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment performed. key further validated ELISA experiments using HSF cells. results show that there 28 dermatitis. GO 1246 terms biological functions, 52 cellular components, 98 molecular functions. KEGG obtained 110 signaling pathways. protein-protein interaction (PPI) showed TNF, NFKB1, MMP-9, IL-2 hub proteins. experiment confirmed reduced levels MMP-9 UBV-induced cells a dose-dependent manner. These findings provide mechanistic evidence supporting as promising functional food, dietary supplements, or medicinal agent skin disorders.

Язык: Английский

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Integrated Transcriptome and Metabolome Analyses Reveal Candidate Genes Associate with Phenolic Compound Biosynthesis in Different Varieties of Perilla frutescens

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2841 - 2841

Опубликована: Март 21, 2025

Perilla frutescens (Perilla) has great potential for utilization in food and medicine due to the abundance of secondary metabolites, especially phenolic compounds. However, molecular mechanism underlying compound synthesis perilla remains poorly understood. By targeted metabolome analysis, we found nine differentially accumulated metabolites among QS2, QS6, QO7 leaves unique which only exist QS6. Furthermore, transcriptome analysis showed differential expression genes (DEGs) were significantly enriched into phenylpropanoid- flavonoid-related pathways. Moreover, integrated analyses indicated 14 candidates highly correlated with biosynthesis. In addition, flavonoid-biosynthesis-related DEGs, including one PAL, CYP73A, 4CL, two CHI, F3H, FLS, three CHS, CYP75B1, ANS, DFR, isolated. The results this study provide useful information metabolic regulation compounds serve as essential gene resources future breeding programs.

Язык: Английский

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