Potential Strategies for Overcoming Drug Resistance Pathways Using Propolis and Its Polyphenolic/Flavonoid Compounds in Combination with Chemotherapy and Radiotherapy

Nutrients, Год журнала: 2024, Номер 16(21), С. 3741 - 3741

Опубликована: Окт. 31, 2024

Conventional cancer treatments include surgical resection, chemotherapy, hyperthermia, immunotherapy, hormone therapy, and locally targeted therapies such as radiation therapy. Standard often require the use of multiple agents, which can activate nuclear factor kappa B (NF-κB) in tumor cells, leading to reduced cell death increased drug resistance. Moreover, agents also contributes added toxicity, resulting poor treatment outcomes. Cancer cells gradually develop resistance almost all chemotherapeutics through various mechanisms, efflux, alterations metabolism transport, changes signal transduction pathways, enhanced DNA repair capacity, evasion apoptosis, mutations, reactivation targets, interaction with microenvironment, cell-stroma interactions, epithelial–mesenchymal transition (EMT)-mediated chemoresistance, epigenetic modifications, metabolic alterations, effect stem (CSCs). Developing new strategies improve chemotherapy sensitivity while minimizing side effects is essential for achieving better therapeutic outcomes enhancing patients’ quality life. One promising approach involves combining conventional propolis its flavonoids. These natural compounds may enhance response reducing toxicity. Propolis components sensitize chemotherapeutic likely by inhibiting NF-κB activation, reprogramming tumor-associated macrophages (TAMs; an M2-like phenotype), thereby release matrix metalloproteinase (MMP)-9, cytokines, chemokines, vascular endothelial growth (VEGF). By TAMs, overcome EMT-mediated disrupt crosstalk between CSCs, inhibit maintenance stemness, reverse acquired immunosuppression, thus promoting antitumor mediated cytotoxic T-cells. This review highlights potential flavonoids modulate responsiveness modalities. The evidence suggests that novel incorporating could be developed positive cytotoxicity peripheral blood leukocytes, liver, kidney cells. Therefore, polyphenolic/flavonoid hold combination clinical types cancers.

Язык: Английский

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Herbacetin as a Novel Ferroptosis Inhibitor for Mitigating Myocardial Damage Induced by Doxorubicin

Опубликована: Янв. 1, 2025

Язык: Английский

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Verbascoside attenuates myocardial ischemia/reperfusion-induced ferroptosis following heterotopic heart transplantation via modulating GDF15/GPX4/SLC7A11 pathway

Опубликована: Апрель 9, 2025

Myocardial cold ischemia/reperfusion (I/R) injury is an inevitable consequence of heart transplantation, significantly affecting survival rates and therapeutic outcomes. Growth Differentiation Factor 15 (GDF15) has been shown to regulate GPX4-mediated ferroptosis, playing a critical role in mitigating I/R injury. Meanwhile, verbascoside (VB), active compound extracted from the herbaceous plant, demonstrated myocardial protective effects. In this study, transplantation was performed using modified non-suture cuff technique, with VB administered at dose 20 mg/kg/day via intraperitoneal injection for 3 days vivo. vitro, cardiomyocytes were pretreated 50 µg/ml 24 hours. treatment reduced histopathological injury, decreased markers, inhibited ferroptosis oxidative stress during vitro experiments further that GDF15 alleviates induced by hypoxic reoxygenation upregulating GPX4. Therefore, it concluded preconditioning can effectively reduce after ectopic possibly through up-regulation GDF15/GPX4/SLC7A11 pathway.

Язык: Английский

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Smart Design of Targeted Drug Delivery System for Precise Drug Delivery and Visual Treatment of Brain Gliomas

Advanced Healthcare Materials, Год журнала: 2024, Номер 14(4)

Опубликована: Дек. 20, 2024

Abstract In the treatment of glioma, which is one malignant tumors, although chemotherapy used as most common method, it often suffers from low bioavailability. Therefore, improving precision and efficiency drugs crucial in treating gliomas a great challenge. Here, an advanced drug delivery system reported for (CZQD@HA@DOX), aggregates multiple features such susceptible imaging tracer property due to use CZQD targeting HA receptor cluster 44 (CD44) glioma cells, provides with functions targeted enrichment precise at tumor site. The pH‐responsive has not only excellent encapsulation rate but also high loading capacity, doxorubicin loaded on can be released centrally microenvironment site causes increase reactive oxygen species mitochondria trigger oxidative stress, leads expression Bax apoptotic proteins, ultimately activating mitochondrial pathway‐mediated process cells. Overall, this potential application therapy visual gliomas.

Язык: Английский

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Endothelial-derived exosomes: A novel therapeutic strategy for LPS-induced myocardial damage with anisodamine

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 136993 - 136993

Опубликована: Ноя. 1, 2024

Язык: Английский

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