Promising and challenging phytochemicals targeting LC3 mediated autophagy signaling in cancer therapy DOI Creative Commons
Peramaiyan Rajendran, Kaviyarasi Renu, Enas M. Ali

и другие.

Immunity Inflammation and Disease, Год журнала: 2024, Номер 12(10)

Опубликована: Окт. 1, 2024

Abstract Background Phytochemicals possess a wide range of anti‐tumor properties, including the modulation autophagy and regulation programmed cell death. Autophagy is critical process in cellular homeostasis its dysregulation associated with several pathological conditions, such as cancer, neurodegenerative diseases, diabetes. In plays dual role by either promoting tumor growth or suppressing it, depending on context. During autophagy, autophagosomes engulf cytoplasmic components proteins organelles. LC3‐II (microtubule‐associated protein 1 light chain 3‐II) an established marker autophagosome formation, making it central to monitoring mammals. Objective To explore regulatory phytochemicals LC3‐mediated their potential therapeutic impact cancer. The review emphasizes involvement promotion suppression, particularly focusing autophagy‐related signaling pathways like oxidative stress through NRF2 pathway, implications for genomic stability cancer development. Methods focuses comprehensive analysis bioactive compounds Curcumin, Celastrol, Resveratrol, Kaempferol, Naringenin, Carvacrol, Farnesol, Piperine. Literature these was examined assess influence LC3 expression, tumor‐related pathways. A systematic literature search conducted across databases PubMed, Scopus, Web Science from inception 2023. Studies were selected prominent databases, roles diagnosis interventions, relation mechanisms. Results have been shown modulate levels autophagic flux cells. interaction between other stress, inflammation, epigenetic highlights complex biology. For instance, Curcumin Resveratrol reported induce inhibit type, influencing progression responses. Conclusion Targeting presents promising strategy therapy. suppression promotion, however, necessitates careful consideration context which induced inhibited. Future research should aim delineate context‐specific how can be optimized efficacy. Novel strategies focus use fine‐tune thereby maximizing inducing death

Язык: Английский

Paeoniflorin protects hepatocytes from APAP-induced damage through launching autophagy via the MAPK/mTOR signaling pathway DOI Creative Commons
Xinyu Deng, Yubing Li, Yuan Chen

и другие.

Cellular & Molecular Biology Letters, Год журнала: 2024, Номер 29(1)

Опубликована: Сен. 7, 2024

Язык: Английский

Процитировано

14
Flavonoids and Gastric Cancer Therapy: From Signaling Pathway to Therapeutic Significance DOI Creative Commons

Jiaying Cai,

Xiyue Tan,

Qichao Hu

и другие.

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 3233 - 3253

Опубликована: Июль 1, 2024

Gastric cancer (GC) is a prevalent gastrointestinal tumor characterized by high mortality and recurrence rates. Current treatments often have limitations, prompting researchers to explore novel anti-tumor substances develop new drugs. Flavonoids, natural compounds with diverse biological activities, are gaining increasing attention in this regard. We searched from PubMed, Web of Science, SpringerLink other databases find the relevant literature last two decades. Using "gastric cancer", "stomach cancers", "flavonoid", "bioflavonoid", "2-Phenyl-Chromene" as keywords, were searched, then analyzed summarized mechanism flavonoids treatment GC. It was revealed that involves inhibiting growth, proliferation, invasion, metastasis, well inducing cell death through various processes such apoptosis, autophagy, ferroptosis, pyroptosis. Additionally, combining chemotherapeutic agents like 5-FU platinum can potentially reduce chemoresistance. Flavonoids also demonstrated enhanced activity when used combination products. Consequently, review proposes innovative perspectives for development anti-GC agents.

Язык: Английский

Процитировано

11
Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer DOI Open Access
Kazi Rejvee Ahmed, Md. Masudur Rahman, Md. Nahidul Islam

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116497 - 116497

Опубликована: Март 28, 2024

The study of chemicals extracted from natural sources should be encouraged due to the significant number cancer deaths each year and financial burden imposed by this disease on society. causes almost all cancers involve a combination lifestyle, environmental factors, genetic inherited factors. Modern medicine researchers are increasingly interested in traditional phytochemicals as they hold potential for new bioactive compounds with medical applications. Recent publications have provided evidence antitumor properties phytochemicals, key component Chinese medicine, thereby opening avenues their use modern medicine. Various studies demonstrated strong correlation between apoptosis autophagy, two critical mechanisms involved formation regulation, indicating diverse forms crosstalk them. Phytochemicals ability activate both pro-apoptotic pro-autophagic pathways. Therefore, understanding how influence relationship autophagy is crucial developing treatment strategy that targets these molecular mechanisms. This review aims explore anticancer effects, focusing role regulating which contributes uncontrolled tumor cell growth. Additionally, highlights limitations challenges current research methodologies while suggesting future field.

Язык: Английский

Процитировано

8
Kaempferol from Alpinia officinarum hance induces G2/M cell cycle arrest in hepatocellular carcinoma cells by regulating the ATM/CHEK2/KNL1 pathway DOI
Xiaoliang Li, Mingyan Zhou, Zhe Zhu

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 333, С. 118430 - 118430

Опубликована: Июнь 8, 2024

Язык: Английский

Процитировано

7
Animal-derived natural products for hepatocellular carcinoma therapy: current evidence and future perspectives DOI Creative Commons

Yichao Liao,

Feng Wei,

Zhelin He

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Май 9, 2024

Hepatocellular carcinoma (HCC) has a high morbidity and mortality rate, the survival rate of HCC patients remains low. Animal medicines have been used as potential therapeutic tools throughout long history due to their different structures biologically active substances with affinity human body. Here, we focus on effects mechanism action animal-derived natural products against HCC, which were searched in databases encompassing Web Science, PubMed, Embase, Science Direct, Springer Link, EBSCO. A total 24 from 12 animals summarized. Our study found that these potent anti-hepatocellular effects. The involving apoptosis induction, autophagy anti-proliferation, anti-migration, anti-drug resistance via phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target rapamycin (mTOR), Ras/extracellular signal regulated kinases (ERK)/mitogen-activated protein (MAPK), Wnt/β-catenin, Janus (JAK)/signal transducer activator transcription (STAT) pathways. Huachansu injection sodium cantharidate clinical applications good efficacy. We review derivatives treatment date summarize application prospect toxic side effects, hoping provide reference for drug development HCC.

Язык: Английский

Процитировано

4
DPHC from Alpinia officinarum Hance specifically modulates the function of CENPU in the cell cycle and apoptosis to ameliorate hepatocellular carcinoma DOI

Zhe Zhu,

Xiuxia Lian,

Jicheng Hu

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119598 - 119598

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Advancements in Utilizing Natural Compounds for Modulating Autophagy in Liver Cancer: Molecular Mechanisms and Therapeutic Targets DOI Creative Commons
Md. Ataur Rahman, S M Rakib-Uz-Zaman, Somdeepa Chakraborti

и другие.

Cells, Год журнала: 2024, Номер 13(14), С. 1186 - 1186

Опубликована: Июль 12, 2024

Autophagy, an intrinsic catabolic mechanism that eliminates misfolded proteins, dysfunctional organelles, and lipid droplets, plays a vital function in energy balance cytoplasmic quality control, addition to maintaining cellular homeostasis. Liver cancer such as hepatocellular carcinoma (HCC) is one of the most common causes deaths globally shows resistance several anticancer drugs. Despite rising incidence poor prognosis malignant HCC, underlying molecular mechanisms driving this aggressive remain unclear. Several natural compounds, phytochemicals dietary non-dietary origin, affect hepatocarcinogenesis signaling pathways vitro vivo, which may help prevent treat HCC cells. Current cells treatments include chemotherapy, radiation, surgery. However, these standard therapies have substantial side effects, combination therapy enhances effects for acceptable therapeutic benefit. Therefore, there need develop treatment strategies are more efficacious fewer adverse effects. Multiple genetic epigenetic factors responsible become resistant treatment. Autophagy contributes maintain homeostasis, activates autophagy biosynthesis mitochondrial regulation recycling. modifying autophagic would present promising opportunity identify novel current treatments. This comprehensive review illustrates how compounds demonstrate their anti-hepatocellular through autophagy.

Язык: Английский

Процитировано

2
Promising and challenging phytochemicals targeting LC3 mediated autophagy signaling in cancer therapy DOI Creative Commons
Peramaiyan Rajendran, Kaviyarasi Renu, Enas M. Ali

и другие.

Immunity Inflammation and Disease, Год журнала: 2024, Номер 12(10)

Опубликована: Окт. 1, 2024

Abstract Background Phytochemicals possess a wide range of anti‐tumor properties, including the modulation autophagy and regulation programmed cell death. Autophagy is critical process in cellular homeostasis its dysregulation associated with several pathological conditions, such as cancer, neurodegenerative diseases, diabetes. In plays dual role by either promoting tumor growth or suppressing it, depending on context. During autophagy, autophagosomes engulf cytoplasmic components proteins organelles. LC3‐II (microtubule‐associated protein 1 light chain 3‐II) an established marker autophagosome formation, making it central to monitoring mammals. Objective To explore regulatory phytochemicals LC3‐mediated their potential therapeutic impact cancer. The review emphasizes involvement promotion suppression, particularly focusing autophagy‐related signaling pathways like oxidative stress through NRF2 pathway, implications for genomic stability cancer development. Methods focuses comprehensive analysis bioactive compounds Curcumin, Celastrol, Resveratrol, Kaempferol, Naringenin, Carvacrol, Farnesol, Piperine. Literature these was examined assess influence LC3 expression, tumor‐related pathways. A systematic literature search conducted across databases PubMed, Scopus, Web Science from inception 2023. Studies were selected prominent databases, roles diagnosis interventions, relation mechanisms. Results have been shown modulate levels autophagic flux cells. interaction between other stress, inflammation, epigenetic highlights complex biology. For instance, Curcumin Resveratrol reported induce inhibit type, influencing progression responses. Conclusion Targeting presents promising strategy therapy. suppression promotion, however, necessitates careful consideration context which induced inhibited. Future research should aim delineate context‐specific how can be optimized efficacy. Novel strategies focus use fine‐tune thereby maximizing inducing death

Язык: Английский

Процитировано

2