New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite
Discover Oncology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Фев. 1, 2025
Pancreatic
cancer
is
an
extremely
deadly
illness
for
which
there
are
few
reliable
treatments.
Recent
research
indicates
that
malignant
tumors
highly
variable
and
consist
of
a
tiny
subset
unique
cells,
known
as
stem
cells
(CSCs),
responsible
the
beginning
spread
tumors.
These
typically
identified
by
expression
specific
cell
surface
markers.
A
population
pancreatic
with
aberrantly
active
developmental
signaling
pathways
has
been
in
recent
studies
human
Among
these
Notch
pathway
key
regulator
CSCs
self-renewal,
making
it
attractive
target
therapeutic
intervention.
Chrysin-loaded
polylactic
acid
(PLA)
polymeric
nanoparticles
systems
have
growing
interest
using
platforms
improved
drug
delivery.
This
review
aims
to
explore
innovative
strategies
targeted
therapy
optimized
delivery
manipulating
leveraging
PLA-based
systems.
Furthermore,
we
will
assess
capability
PLA
enhance
bioavailability
effectiveness
gemcitabine
cells.
The
insights
gained
from
this
potential
contribute
development
novel
treatment
approaches
combine
advanced
utilizing
biodegradable
nanoparticles.
Язык: Английский
Chondroitin sulfate nanoparticles based on co-delivery dual drug induced ferroptosis in lung cancer cells by disrupting mitochondrial oxidative homeostasis
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101632 - 101632
Опубликована: Март 5, 2025
Язык: Английский
Lycium ruthenicum anthocyanins alleviate acrylamide-induced neurotoxicity in SH-SY5Y cells by mitigating ferroptosis via the Nrf2/GPX4 signaling pathway
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106415 - 106415
Опубликована: Март 1, 2025
Язык: Английский
Transcriptomic and metabolomic analyses reveal phenolic metabolism regulated by melatonin in pear peel
Chemical and Biological Technologies in Agriculture,
Год журнала:
2025,
Номер
12(1)
Опубликована: Апрель 3, 2025
Язык: Английский
Therapeutic potential of resveratrol through ferroptosis modulation: insights and future directions in disease therapeutics
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 25, 2024
Resveratrol,
a
naturally
occurring
polyphenolic
compound,
has
captivated
the
scientific
community
with
its
promising
therapeutic
potential
across
spectrum
of
diseases.
This
review
explores
complex
role
resveratrol
in
modulating
ferroptosis,
newly
identified
form
programmed
cell
death,
and
implications
for
managing
cardiovascular
cerebrovascular
disorders,
cancer,
other
conditions.
Ferroptosis
is
intricately
linked
to
pathogenesis
diverse
diseases,
exerting
multifaceted
effects
on
this
process.
It
mitigates
ferroptosis
by
lipid
peroxidation,
iron
accumulation,
engaging
specific
cellular
receptors,
thereby
manifesting
profound
benefits
conditions,
as
well
oncological
settings.
Moreover,
resveratrol's
capacity
either
suppress
or
induce
through
modulation
signaling
pathways,
including
Sirt1
Nrf2,
unveils
novel
avenues.
Despite
limited
bioavailability,
advancements
molecular
modification
drug
delivery
optimization
have
amplified
clinical
utility.
Future
investigations
are
poised
unravel
comprehensive
mechanisms
underpinning
action
expand
repertoire.
We
hope
could
furnish
detailed
insight
into
exploration
regulation
prospects.
Язык: Английский
Design, synthesis and biological evaluation of marine naphthoquinone-naphthol derivatives as potential anticancer agents
Journal of Enzyme Inhibition and Medicinal Chemistry,
Год журнала:
2024,
Номер
39(1)
Опубликована: Окт. 15, 2024
1'-Hydroxy-4',8,8'-trimethoxy-[2,2'-binaphthalene]-1,4-dione
(compound
Язык: Английский