New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 1, 2025

Pancreatic cancer is an extremely deadly illness for which there are few reliable treatments. Recent research indicates that malignant tumors highly variable and consist of a tiny subset unique cells, known as stem cells (CSCs), responsible the beginning spread tumors. These typically identified by expression specific cell surface markers. A population pancreatic with aberrantly active developmental signaling pathways has been in recent studies human Among these Notch pathway key regulator CSCs self-renewal, making it attractive target therapeutic intervention. Chrysin-loaded polylactic acid (PLA) polymeric nanoparticles systems have growing interest using platforms improved drug delivery. This review aims to explore innovative strategies targeted therapy optimized delivery manipulating leveraging PLA-based systems. Furthermore, we will assess capability PLA enhance bioavailability effectiveness gemcitabine cells. The insights gained from this potential contribute development novel treatment approaches combine advanced utilizing biodegradable nanoparticles.

Language: Английский

---

Chondroitin sulfate nanoparticles based on co-delivery dual drug induced ferroptosis in lung cancer cells by disrupting mitochondrial oxidative homeostasis

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101632 - 101632

Published: March 5, 2025

Language: Английский

---

Lycium ruthenicum anthocyanins alleviate acrylamide-induced neurotoxicity in SH-SY5Y cells by mitigating ferroptosis via the Nrf2/GPX4 signaling pathway

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106415 - 106415

Published: March 1, 2025

Language: Английский

---

Transcriptomic and metabolomic analyses reveal phenolic metabolism regulated by melatonin in pear peel

Chemical and Biological Technologies in Agriculture, Journal Year: 2025, Volume and Issue: 12(1)

Published: April 3, 2025

Language: Английский

---

Therapeutic potential of resveratrol through ferroptosis modulation: insights and future directions in disease therapeutics

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 25, 2024

Resveratrol, a naturally occurring polyphenolic compound, has captivated the scientific community with its promising therapeutic potential across spectrum of diseases. This review explores complex role resveratrol in modulating ferroptosis, newly identified form programmed cell death, and implications for managing cardiovascular cerebrovascular disorders, cancer, other conditions. Ferroptosis is intricately linked to pathogenesis diverse diseases, exerting multifaceted effects on this process. It mitigates ferroptosis by lipid peroxidation, iron accumulation, engaging specific cellular receptors, thereby manifesting profound benefits conditions, as well oncological settings. Moreover, resveratrol's capacity either suppress or induce through modulation signaling pathways, including Sirt1 Nrf2, unveils novel avenues. Despite limited bioavailability, advancements molecular modification drug delivery optimization have amplified clinical utility. Future investigations are poised unravel comprehensive mechanisms underpinning action expand repertoire. We hope could furnish detailed insight into exploration regulation prospects.

Language: Английский

---

Design, synthesis and biological evaluation of marine naphthoquinone-naphthol derivatives as potential anticancer agents

Journal of Enzyme Inhibition and Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 39(1)

Published: Oct. 15, 2024

1'-Hydroxy-4',8,8'-trimethoxy-[2,2'-binaphthalene]-1,4-dione (compound

Language: Английский

---