Network Pharmacology-driven therapeutic interventions for Interstitial Lung Diseases using Traditional medicines: A Narrative Review
International Immunopharmacology,
Год журнала:
2025,
Номер
147, С. 113979 - 113979
Опубликована: Янв. 1, 2025
This
review
explores
the
progressive
domain
of
network
pharmacology
and
its
potential
to
revolutionize
therapeutic
approaches
for
Interstitial
Lung
Diseases
(ILDs),
a
collective
term
encompassing
Pneumonia,
Pneumoconiosis,
Connective
Tissue
Disease-related
ILDs,
Sarcoidosis.
The
exploration
focuses
on
profound
legacy
traditional
medicines,
particularly
Ayurveda
Traditional
Chinese
Medicines
(TCM),
their
largely
unexplored
capacity
in
ILD
treatment.
These
ancient
healing
systems,
characterized
by
holistic
methodologies
multifaceted
treatment
modalities,
offer
promising
foundation
discovering
innovative
strategies.
Moreover,
underscores
amalgamation
artificial
intelligence
(AI)
machine
learning
(ML)
with
bioinformatics,
creating
computational
synergy
capable
deciphering
intricate
biological
networks
associated
ILDs.
Network
has
tailored
hypothesis
from
conventional
"one
target,
one
drug"
towards
"network
multi-component
therapeutics"
approach.
fusion
literature
technology
can
unveil
novel
drugs,
targets,
pathways,
augmenting
effective
therapies
diminishing
adverse
effects
related
current
medications.
In
conclusion,
this
provides
comprehensive
exposition
how
Pharmacology
tools
leverage
insights
TCM
craft
efficacious
solutions
It
sets
stage
future
investigations
captivating
interdisciplinary
domain,
validating
use
medicines
worldwide.
Язык: Английский
Regulation of detoxifying enzymes expression and restriction of picorna-like virus infection by natural polysaccharide extracts in Drosophila cells
Virology,
Год журнала:
2025,
Номер
unknown, С. 110513 - 110513
Опубликована: Март 1, 2025
Язык: Английский
Herbal Extracts Mixed with Essential Oils: A Network Approach for Gastric and Intestinal Motility Disorders
Nutrients,
Год журнала:
2024,
Номер
16(24), С. 4357 - 4357
Опубликована: Дек. 17, 2024
Background:
Three
herbal
extracts
(Asparagus
racemosus
Willd.,
Tabebuia
avellanedae
Lorentz,
and
Glycyrrhiza
glabra
L.)
were
mixed
with
three
essential
oils
(Foeniculum
vulgare
Mill.,
Mentha
piperita
L.,
Pimpinella
anisum
to
formulate
a
product
(HEMEO)
whose
active
compounds
include
saponins
steroids
in
Asparagus
racemosus,
known
for
their
anti-inflammatory
properties;
glycyrrhizin
flavonoids
glabra,
which
exhibit
gastroprotective
antispasmodic
effects;
menthol
piperita,
contributing
antimicrobial
anethole
polyphenols
anisum,
modulate
intestinal
motility
offer
activity.
Objective:
HEMEO
was
formulated
applications
disorders.
Methods:
evaluated
spontaneous
induced
effects
isolated
guinea
pig
ileum,
colon,
stomach.
Ex
vivo
experiments
conducted
using
LabChart
software
v7.0,
the
product’s
antibacterial
action
against
Helicobacter
pylori
its
antioxidant
assessed
through
disc
diffusion
FRAP
assays.
The
presence
of
volatile
formulation
confirmed
by
GC-MS
analysis;
TPC
HEMEO,
determined
Folin–Ciocalteu
method,
9.925
±
0.42
mg
GAE/g.
Conclusions:
showed
phenolic
content
correlated
potential
addition
inhibited
H.
growth
demonstrated
notable
properties,
suggesting
role
as
supportive
agent
digestive
processes
managing
Язык: Английский