Network Pharmacology-driven therapeutic interventions for Interstitial Lung Diseases using Traditional medicines: A Narrative Review

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 113979 - 113979

Published: Jan. 1, 2025

This review explores the progressive domain of network pharmacology and its potential to revolutionize therapeutic approaches for Interstitial Lung Diseases (ILDs), a collective term encompassing Pneumonia, Pneumoconiosis, Connective Tissue Disease-related ILDs, Sarcoidosis. The exploration focuses on profound legacy traditional medicines, particularly Ayurveda Traditional Chinese Medicines (TCM), their largely unexplored capacity in ILD treatment. These ancient healing systems, characterized by holistic methodologies multifaceted treatment modalities, offer promising foundation discovering innovative strategies. Moreover, underscores amalgamation artificial intelligence (AI) machine learning (ML) with bioinformatics, creating computational synergy capable deciphering intricate biological networks associated ILDs. Network has tailored hypothesis from conventional "one target, one drug" towards "network multi-component therapeutics" approach. fusion literature technology can unveil novel drugs, targets, pathways, augmenting effective therapies diminishing adverse effects related current medications. In conclusion, this provides comprehensive exposition how Pharmacology tools leverage insights TCM craft efficacious solutions It sets stage future investigations captivating interdisciplinary domain, validating use medicines worldwide.

Language: Английский

Regulation of detoxifying enzymes expression and restriction of picorna-like virus infection by natural polysaccharide extracts in Drosophila cells

Virology, Journal Year: 2025, Volume and Issue: unknown, P. 110513 - 110513

Published: March 1, 2025

Language: Английский

Herbal Extracts Mixed with Essential Oils: A Network Approach for Gastric and Intestinal Motility Disorders

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4357 - 4357

Published: Dec. 17, 2024

Background: Three herbal extracts (Asparagus racemosus Willd., Tabebuia avellanedae Lorentz, and Glycyrrhiza glabra L.) were mixed with three essential oils (Foeniculum vulgare Mill., Mentha piperita L., Pimpinella anisum to formulate a product (HEMEO) whose active compounds include saponins steroids in Asparagus racemosus, known for their anti-inflammatory properties; glycyrrhizin flavonoids glabra, which exhibit gastroprotective antispasmodic effects; menthol piperita, contributing antimicrobial anethole polyphenols anisum, modulate intestinal motility offer activity. Objective: HEMEO was formulated applications disorders. Methods: evaluated spontaneous induced effects isolated guinea pig ileum, colon, stomach. Ex vivo experiments conducted using LabChart software v7.0, the product’s antibacterial action against Helicobacter pylori its antioxidant assessed through disc diffusion FRAP assays. The presence of volatile formulation confirmed by GC-MS analysis; TPC HEMEO, determined Folin–Ciocalteu method, 9.925 ± 0.42 mg GAE/g. Conclusions: showed phenolic content correlated potential addition inhibited H. growth demonstrated notable properties, suggesting role as supportive agent digestive processes managing

Language: Английский